[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100480700":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":41,"centralContacts":46,"locations":52,"responsibleParty":335,"collaborators":27,"id":337,"slug":27,"hasResults":338,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":338,"sex":344,"minAge":345,"maxAge":27,"enrollmentInfo":346,"targetDuration":27,"studyType":349,"phases":350,"briefSummary":352,"conditions":353,"keywords":357,"overallStatus":55,"whyStopped":27,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":374},{"fullName":5,"class":6},"University Hospital, Bordeaux","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment group","EXPERIMENTAL","Combination rapid sequence intubation (RSI) with use of rocuronium and the bag-mask ventilation between induction and Gum Elastic Bougie GEB will be systematically used at the first attempt to facilitate intubation.",[13,14,15],"Other: Data patient","Other: Physical examination","Procedure: Rapid sequence intubation (RSI) : Rocuronium \u002FBag-mask ventilation \u002FGEB",{"label":17,"type":18,"description":19,"interventionNames":20},"Control Group","ACTIVE_COMPARATOR","Physicians will be reminded of the current recommendations for emergency intubation: Rapid sequence intubation (RSI) using succinylcholine and use of GEB to facilitate intubation in case of intubation failure under direct laryngoscopy.",[13,14,21],"Procedure: Rapid sequence intubation (RSI) : Recommendations for emergency intubation",[23,28,32,37],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"Data patient","Medical History and characteristic of patient",[17,9],null,{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Physical examination","Arterial pressure, arterial oxygen saturation, heart rate",[17,9],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"PROCEDURE","Rapid sequence intubation (RSI) : Rocuronium \u002FBag-mask ventilation \u002FGEB","Rapid sequence intubation (RSI) will be performed with use of rocuronium as paralytic agent (1.2 mg\u002F kg). Bag-mask ventilation between induction and laryngoscopy will be performed. The GEB will be systematically used at the first attempt to facilitate intubation.",[9],{"type":33,"name":38,"description":39,"armGroupLabels":40,"otherNames":27},"Rapid sequence intubation (RSI) : Recommendations for emergency intubation","Rapid sequence intubation (RSI) using succinylcholine as a paralytic agent (1 mg\u002Fkg), no systematic bag-mask ventilation between induction and laryngoscopy, use of GEB to facilitate intubation in case of intubation failure under direct laryngoscopy.",[17],[42],{"name":43,"affiliation":44,"role":45},"Xavier COMBES, Pr","Université Hospital, Bordeaux","PRINCIPAL_INVESTIGATOR",[47],{"name":43,"role":48,"phone":49,"phoneExt":50,"email":51},"CONTACT","05 56 79 49 47","033","xavier.combes@chu-bordeaux.fr",[53,69,82,95,108,120,133,147,160,173,186,199,212,225,238,251,264,273,283,296,309,322],{"facility":54,"status":55,"city":56,"state":27,"zip":57,"country":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"CHU d'Angers","RECRUITING","Angers","49933","France",{"type":60,"coordinates":61},"Point",[62,63],-0.55202,47.47156,{"lat":63,"lon":62},[66],{"name":67,"role":48,"phone":27,"phoneExt":27,"email":68},"Dominique SAVARY","dominique.savary@chu-angers.fr",{"facility":70,"status":55,"city":71,"state":27,"zip":72,"country":58,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"CH Carnelle Portes de l'Oise","Beaumont-sur-Oise","95260",{"type":60,"coordinates":74},[75,76],2.28705,49.14232,{"lat":76,"lon":75},[79],{"name":80,"role":48,"phone":27,"phoneExt":27,"email":81},"Agnès Agnès RICARD-HIBON","agnes.ricard-hibon@ght-novo.fr",{"facility":83,"status":55,"city":84,"state":27,"zip":85,"country":58,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"AP-HP - Hôpital Avicenne","Bobigny","93000",{"type":60,"coordinates":87},[88,89],2.45012,48.90982,{"lat":89,"lon":88},[92],{"name":93,"role":48,"phone":27,"phoneExt":27,"email":94},"Frédéric LAPOSTOLLE","frederic.lapostolle@aphp.fr",{"facility":96,"status":55,"city":97,"state":27,"zip":98,"country":58,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"CHU de Bordeaux - Hôpital Pellegrin","Bordeaux","33000",{"type":60,"coordinates":100},[101,102],-0.58046,44.84124,{"lat":102,"lon":101},[105,106],{"name":43,"role":48,"phone":27,"phoneExt":27,"email":51},{"name":107,"role":45,"phone":27,"phoneExt":27,"email":27},"Xavier COMBES, PR",{"facility":109,"status":55,"city":110,"state":27,"zip":111,"country":58,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"CH de Pontoise René Dubos","Cergy-Pontoise","95303",{"type":60,"coordinates":113},[114,115],2.07805,49.03894,{"lat":115,"lon":114},[118],{"name":119,"role":48,"phone":27,"phoneExt":27,"email":81},"Agnès RICARD-HIBON",{"facility":121,"status":55,"city":122,"state":27,"zip":123,"country":58,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"AP-HP - Hôpital Henri Mondor","Créteil","94000",{"type":60,"coordinates":125},[126,127],2.46569,48.79266,{"lat":127,"lon":126},[130],{"name":131,"role":48,"phone":27,"phoneExt":27,"email":132},"Charlotte CHOLLET-XEMARD","charlotte.chollet@aphp.fr",{"facility":134,"status":135,"city":136,"state":27,"zip":137,"country":58,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"CHU de Dijon","NOT_YET_RECRUITING","Dijon","21000",{"type":60,"coordinates":139},[140,141],5.01391,47.31344,{"lat":141,"lon":140},[144],{"name":145,"role":48,"phone":27,"phoneExt":27,"email":146},"Patrick RAY","patrick.ray@chu-dijon.fr",{"facility":148,"status":55,"city":149,"state":27,"zip":150,"country":58,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"GH Eaubonne Montmorency Hôpital Simone VEIL","Eaubonne","95600",{"type":60,"coordinates":152},[153,154],2.28249,48.99712,{"lat":154,"lon":153},[157],{"name":158,"role":48,"phone":27,"phoneExt":27,"email":159},"Laure GUILLOUX","laure.guilloux@hotmail.fr",{"facility":161,"status":55,"city":162,"state":27,"zip":163,"country":58,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"AP-HP - Hôpital Raymond Poincaré","Garches","92380",{"type":60,"coordinates":165},[166,167],2.18232,48.84226,{"lat":167,"lon":166},[170],{"name":171,"role":48,"phone":27,"phoneExt":27,"email":172},"Armelle SEVERIN","armelle.severin@aphp.fr",{"facility":174,"status":55,"city":175,"state":27,"zip":176,"country":58,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"CHU de Grenoble - Hôpital Nord La Tronche","La Tronche","38700",{"type":60,"coordinates":178},[179,180],5.74629,45.20507,{"lat":180,"lon":179},[183],{"name":184,"role":48,"phone":27,"phoneExt":27,"email":185},"Guillaume DEBATY","gdebaty@chu-grenoble.fr",{"facility":187,"status":135,"city":188,"state":27,"zip":189,"country":58,"cosmosGeoPoint":190,"geoPoint":194,"contacts":195},"CH de Versailles - Site André Mignot","Le Chesnay","78157",{"type":60,"coordinates":191},[192,193],2.12213,48.8222,{"lat":193,"lon":192},[196],{"name":197,"role":48,"phone":27,"phoneExt":27,"email":198},"Clotilde CAZENAVE","ccazenave@ght78sud.fr",{"facility":200,"status":55,"city":201,"state":27,"zip":202,"country":58,"cosmosGeoPoint":203,"geoPoint":207,"contacts":208},"HCL - Hôpital Edouard Herriot","Lyon","69003",{"type":60,"coordinates":204},[205,206],4.84789,45.74906,{"lat":206,"lon":205},[209],{"name":210,"role":48,"phone":27,"phoneExt":27,"email":211},"Marine PAUPE","marine.paupe@chu-lyon.fr",{"facility":213,"status":55,"city":214,"state":27,"zip":215,"country":58,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"GH Sud Ile de France","Melun","77000",{"type":60,"coordinates":217},[218,219],2.65356,48.5457,{"lat":219,"lon":218},[222],{"name":223,"role":48,"phone":27,"phoneExt":27,"email":224},"Yousra GUETARI","yousra.guetari@ghsif.fr",{"facility":226,"status":55,"city":227,"state":27,"zip":228,"country":58,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"CHU de Montpellier Site Lapeyronie","Montpellier","34000",{"type":60,"coordinates":230},[231,232],3.87635,43.61093,{"lat":232,"lon":231},[235],{"name":236,"role":48,"phone":27,"phoneExt":27,"email":237},"Xavier BOBBIA","xavier.bobbia@chu-montpellier.fr",{"facility":239,"status":55,"city":240,"state":27,"zip":241,"country":58,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"CHU de Nantes - Hôpital Hôtel Dieu","Nantes","44093",{"type":60,"coordinates":243},[244,245],-1.55336,47.21725,{"lat":245,"lon":244},[248],{"name":249,"role":48,"phone":27,"phoneExt":27,"email":250},"Quentin LE BASTARD","quentin.lebastard@chu-nantes.fr",{"facility":252,"status":55,"city":253,"state":27,"zip":254,"country":58,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"AP-HP - Hôpital Lariboisière","Paris","75013",{"type":60,"coordinates":256},[257,258],2.3488,48.85341,{"lat":258,"lon":257},[261],{"name":262,"role":48,"phone":27,"phoneExt":27,"email":263},"Xavier EYER","xavier.eyer@aphp.fr",{"facility":265,"status":55,"city":253,"state":27,"zip":254,"country":58,"cosmosGeoPoint":266,"geoPoint":268,"contacts":269},"AP-HP - Hôpital Pitié-Salpétrière",{"type":60,"coordinates":267},[257,258],{"lat":258,"lon":257},[270],{"name":271,"role":48,"phone":27,"phoneExt":27,"email":272},"Patrick ECOLLAN","patrick.ecollan@aphp.fr",{"facility":274,"status":55,"city":253,"state":27,"zip":275,"country":58,"cosmosGeoPoint":276,"geoPoint":278,"contacts":279},"AP-HP - Hôpital Necker","75730",{"type":60,"coordinates":277},[257,258],{"lat":258,"lon":257},[280],{"name":281,"role":48,"phone":27,"phoneExt":27,"email":282},"Thomas NICOL","thomas.nicol@aphp.fr",{"facility":284,"status":55,"city":285,"state":27,"zip":286,"country":58,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"CHU Poitiers - Hôpital la Milétrie","Poitiers","86021",{"type":60,"coordinates":288},[289,290],0.34348,46.58261,{"lat":290,"lon":289},[293],{"name":294,"role":48,"phone":27,"phoneExt":27,"email":295},"Nicolas MARJANOVIC","nicolas.marjanovic@chu-poitiers.fr",{"facility":297,"status":55,"city":298,"state":27,"zip":299,"country":58,"cosmosGeoPoint":300,"geoPoint":304,"contacts":305},"CHU de la Réunion - site Sud","Saint-Pierre","97448",{"type":60,"coordinates":301},[302,303],5.40682,43.29282,{"lat":303,"lon":302},[306],{"name":307,"role":48,"phone":27,"phoneExt":27,"email":308},"Adrien MARTEAU","adrien.marteau@chu-reunion.fr",{"facility":310,"status":135,"city":311,"state":27,"zip":312,"country":58,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"GH Sélestat Obernai","Sélestat","67 600",{"type":60,"coordinates":314},[315,316],7.4489,48.26195,{"lat":316,"lon":315},[319],{"name":320,"role":48,"phone":27,"phoneExt":27,"email":321},"Gautier DROMSON","gautier.dromson@ghso.fr",{"facility":323,"status":55,"city":324,"state":27,"zip":325,"country":58,"cosmosGeoPoint":326,"geoPoint":330,"contacts":331},"CHU Toulouse - Hôpital Purpan","Toulouse","31059",{"type":60,"coordinates":327},[328,329],1.44367,43.60426,{"lat":329,"lon":328},[332],{"name":333,"role":48,"phone":27,"phoneExt":27,"email":334},"Bertrand GUIHARD","guihard.b@chu-toulouse.fr",{"type":336,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100480700",false,"NCT05539391","Optimisation Strategy for Emergency Tracheal Intubation","Effectiveness of an Optimisation Strategy for Emergency Tracheal Intubation on Postintubation Morbidity: A Cluster Randomized Controlled Trial","OSETIM","Inclusion Criteria:\n\n* Patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting.\n* Patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included.\n\nExclusion Criteria:\n\n* Patient presenting of a contraindication to succinylcholine, and\u002For rocuronium, and\u002For sugammadex (rocunorium antagonist).\n* Patient who have contraindication to bag face mask ventilation before intubation (ongoing emesis, hematemesis, or hemoptysis).\n* Patient that are not members of a medical aid scheme (beneficiary or main member).\n* Patient under specific protection measures: pregnant, parturient or nursing women; legal protection or deprived of liberty: patient under judicial protection, patient under guardianship\u002Fcuratorship.","ALL","18 Years",{"count":347,"type":348},1500,"ESTIMATED","INTERVENTIONAL",[351],"NA","This study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity. This strategy will associate systematic use of rocuronium as paralyzing agent to facilitate tracheal intubation, bag face-mask ventilation before intubation and Gum Elastic Bougie (GEB) use.",[354,355,356],"Emergencies","Out-of-hospital Setting","Tracheal Intubation",[358,359,360,361,362,363,364],"Out-of-hospital","Intubation","Complications","Vital distress","Rapid sequence intubation","Rocuronium","Gum Elastic Bougie","2025-09-23",{"date":367,"type":368},"2025-09-24","ACTUAL",{"date":370,"type":368},"2023-01-14",{"date":372,"type":348},"2026-09",{"name":5,"class":6},22]