[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645214":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":40,"collaborators":10,"id":44,"slug":10,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":45,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Dexmedetomidine during HFNC",null,"The procedure performed as part of routine clinical practice involves the administration of high-flow nasal oxygen therapy (HFNC), with an initial flow set at 60 L\u002Fmin, potentially reduced to the maximum tolerated flow in case of discomfort. FiO₂ is titrated to maintain the target SpO₂ of 92-96%. Humidification chamber is heated at 37°C or 34°C according to patient's comfort. During the procedure, patients receive sedative-analgesic treatment with dexmedetomidine as a clinical indication decided by the attending physician.",{"label":13,"type":10,"description":14,"interventionNames":10},"Remifentanil during HFNC","The procedure performed as part of routine clinical practice involves the administration of high-flow nasal oxygen therapy (HFNC), with an initial flow set at 60 L\u002Fmin, potentially reduced to the maximum tolerated flow in case of discomfort. FiO₂ is titrated to maintain the target SpO₂ of 92-96%. Humidification chamber is heated at 37°C or 34°C according to patient's comfort. During the procedure, patients receive sedative-analgesic treatment with remifentanil as a clinical indication decided by the attending physician.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Domenico Luca Grieco, MD","CONTACT","+393397681623","dlgrieco@outlook.it",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Gaia Tempo, MD","+393450947767","gaia.tempo9@gmail.com",[26],{"facility":27,"status":10,"city":28,"state":29,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Fondazione Policlinico Universitario A.Gemelli IRCCS","Roma","RM","00168","Italy",{"type":33,"coordinates":34},"Point",[35,36],11.10642,44.99364,{"lat":36,"lon":35},[39],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","GRIECO DOMENICO LUCA","Medical Doctor, Principal Investigator","100645214",false,"NCT07679932","Optimization of Respiratory Effort With Titrated Sedation in AHRF","Optimization of Respiratory Effort With Titrated Sedation in Patients With Acute Hypoxemic Respiratory Failure - The OPTIREST Study","OPTIREST","Inclusion Criteria:\n\n* Age ≥18 years\n* PaO2\u002FFiO2 ratio ≤ 200;\n* PaCO2 \\\u003C 45 mmHg;\n* At least one symptom prompting the use of sedative-analgesic drugs according to the prescription of the attending physician: dyspnea and\u002For discomfort equal of greater than 4\u002F10 (Visual Analog Scale - VAS), respiratory rate equal or greater than 25 breaths per minute, PaCO2\\\u003C35 mmHg, pain (Numeric Rating Scale ≥ 4 or Behavioral Pain Scale - Non-Intubated ≥ 4);\n* Informed consent signature.\n\nExclusion Criteria:\n\n* Pregnancy;\n* Exacerbation of asthma or chronic obstructive pulmonary disease;\n* Chronic lung disease, requiring oxygen therapy at home;\n* Cardiogenic pulmonary oedema;\n* Hemodynamic instability (systolic blood pressure \\\u003C90 mmHg or mean arterial pressure \\\u003C65 mmHg) and\u002For lactic acidosis (lactate \\>5 mmol\u002FL) and\u002For clinically diagnosed shock;\n* Metabolic acidosis (pH \\\u003C7.30 with normal or hypocarbia);\n* Glasgow Coma Scale \\\u003C13;\n* Contraindications to esophageal balloon and\u002For EIT placement.","ALL","18 Years",{"count":54,"type":55},40,"ESTIMATED","OBSERVATIONAL","Prospective, observational, monocentric study to assess the physiological effects of dexmedetomidine and remifentanil in spontaneously breathing patients with acute hypoxemic respiratory failure receiving high-flow nasal oxygen.",[59],"AHRF","NOT_YET_RECRUITING","2026-06-25",{"date":63,"type":64},"2026-07-01","ACTUAL",{"date":66,"type":55},"2026-07",{"date":68,"type":55},"2028-07",{"name":5,"class":6},1]