Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
ConditionHypothyroidism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorUniversity of Michigan
About this trial
The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or discontinuation) in older adults with thyroid hormone overtreatment and/or misuse and reduce patient harm. Findings from this study will lay the groundwork for broad implementation of D-THIO and serve as a model for deprescribing inappropriate medications for other endocrine conditions and conditions with biochemical monitoring.
Eligibility criteria
Qualifiers
age 65 years and older
on thyroid hormone therapy and have a serum Thyroid-stimulating hormone (TSH) <0.5 mIU/L or are on thyroid hormone therapy for an inappropriate indication
English speaking
without cognitive impairment
Disqualifiers
None
Trial design
Treatments tested in this trial
- D-THIO (Deprescribing Thyroid Hormone In Older Adults)
- Enhanced usual care
Treatment groups
900 Participants
are divided into 2 treatment groupsLocations
3University of California San Francisco94143, San FranciscoCalifornia, United States
University of Michigan48109, Ann ArborMichigan, United States
Henry Ford Health System48202, DetroitMichigan, United States
Sponsors and collaborators
University of Michigan
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov