[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603496":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":21,"studyPopulation":13,"armGroups":22,"interventions":29,"overallOfficials":35,"centralContacts":13,"locations":39,"responsibleParty":94,"collaborators":97,"id":101,"slug":13,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":13,"eligibilityCriteria":106,"healthyVolunteers":102,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":13,"studyType":113,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":42,"whyStopped":13,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"Auburn University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Change in rate of behavior across schedules","Number of target responses allocated emitted during experimental sessions in which reinforcement parameters (e.g., schedule arrangement, magnitude, and probability) are systematically varied. This measure will be derived from response data recorded during operant conditioning tasks. Changes in allocation patterns will be compared across schedule conditions to assess the effect of reinforcement manipulations.","3 months",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":17,"primaryPurpose":18,"observationalModel":13,"timePerspective":13,"maskingInfo":19},"NA","SINGLE_GROUP","All participants receive the same sequence of experimental conditions. The design allows for within-subject comparisons across phases of the intervention to evaluate changes in operant responding under different schedule arrangements.","BASIC_SCIENCE",{"masking":20,"maskingDescription":13,"whoMasked":13},"NONE","This study examines how key parameters of reinforcement-specifically the timing and amount of rewards-affect learning, motivation, and performance in individuals with intellectual and developmental disabilities (IDD). The experimental design is informed by the Mathematical Principles of Reinforcement (MPR), a quantitative framework for understanding the relationship between reinforcement schedules and behavior.\n\nParticipants will complete tabletop tasks in a controlled setting. Tasks are designed to be simple and accessible, such as pressing a button or selecting a picture, and correct responses will earn small rewards. Across sessions, we will systematically vary reinforcement parameters, including inter-reinforcement interval and reinforcer magnitude, to evaluate their effects on response rate, accuracy, and persistence.\n\nThis is a Basic Experimental Studies with Humans (BESH) clinical trial, meaning the interventions are intended to understand fundamental behavioral processes, not to produce direct clinical benefit. The data will be analyzed using statistical models derived from MPR to identify which reinforcement dimensions are most effective in maintaining high rates of responding. The results may help refine behavior intervention strategies for individuals with IDD by providing an evidence-based understanding of how to optimize reinforcement delivery.",[23],{"label":24,"type":25,"description":26,"interventionNames":27},"Single-Arm: Manipulation of Reinforcement Schedules","EXPERIMENTAL","Participants will complete an operant conditioning task in which reinforcement schedules are systematically manipulated to evaluate changes in response patterns. All participants receive the same sequence of experimental conditions, which involve varying the availability and distribution of points exchangeable for preferred items or activities. No health-related treatment is provided; the procedures are designed to examine basic behavioral processes related to reinforcement dynamics.",[28],"Behavioral: Operant Conditioning Tasks with Reinforcement Manipulations",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":13},"BEHAVIORAL","Operant Conditioning Tasks with Reinforcement Manipulations","This behavioral intervention involves structured operant conditioning tasks. Reinforcement parameters (e.g., schedule arrangement, magnitude, and probability) are systematically manipulated to evaluate their effects on behavioral allocation. The primary objective is to assess how variations in reinforcement contingencies influence choice patterns. The procedures are designed to examine fundamental behavioral processes rather than to provide therapeutic benefit.",[24],[36],{"name":37,"affiliation":5,"role":38},"John M Falligant, PhD","PRINCIPAL_INVESTIGATOR",[40,64,79],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Center for Autism Research, Treatment, and Training","RECRUITING","Auburn","Alabama","36830","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-85.48078,32.60986,{"lat":52,"lon":51},[55,60],{"name":56,"role":57,"phone":58,"phoneExt":13,"email":59},"John Falligant","CONTACT","205-807-2371","jmf0031@auburn.edu",{"name":61,"role":57,"phone":62,"phoneExt":13,"email":63},"Madeline Levin, M.S.","334-844-4412","mjl0083@auburn.edu",{"facility":65,"status":42,"city":66,"state":67,"zip":68,"country":46,"countryCode":47,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Kennedy Krieger Institute","Baltimore","Maryland","21205",{"type":49,"coordinates":70},[71,72],-76.61219,39.29038,{"lat":72,"lon":71},[75],{"name":76,"role":57,"phone":77,"phoneExt":13,"email":78},"Louis P Hagopian, PhD","443-923-2841","hagopian@kennedykrieger.org",{"facility":80,"status":42,"city":81,"state":82,"zip":83,"country":46,"countryCode":47,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Oakland University","Rochester Hills","Michigan","48309",{"type":49,"coordinates":85},[86,87],-83.14993,42.65837,{"lat":87,"lon":86},[90],{"name":91,"role":57,"phone":92,"phoneExt":13,"email":93},"Michael P Kranak, PhD","304-374-5150","kranak@oakland.edu",{"type":38,"investigatorFullName":95,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"John Michael Falligant","Assistant Professor",[98,99],{"name":80,"class":6},{"name":100,"class":6},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","100603496",false,"NCT07137273","Optimizing Dimensions of Reinforcement","Optimizing Dimensions of Reinforcement to Enhance Behavioral Interventions","Inclusion Criteria:\n\nAt least 6 years of age\n\nDocumented neurodevelopmental condition\n\nEngagement in problem behavior (e.g., aggression, self-injury, property destruction) that can be measured during study sessions\n\nAbility to follow simple instructions\n\nAbility to participate in tabletop choice-based tasks\n\nAvailability to complete all scheduled study sessions\n\nProvision of informed consent by participant or legally authorized representative\n\nExclusion Criteria:\n\nSevere sensory or motor impairments that would prevent participation in tabletop tasks\n\nCurrent or recent participation (within the past 30 days) in another interventional behavioral research study that could interfere with study outcomes\n\nMedical or behavioral conditions judged by investigators to pose a safety risk or interfere with data collection","ALL","6 Years","17 Years",{"count":111,"type":112},30,"ESTIMATED","INTERVENTIONAL",[15],"This study is designed to better understand how certain features of reinforcement affect learning and motivation in individuals with intellectual and developmental disabilities (IDD). Participants will take part in a series of structured teaching sessions that involve simple tasks and reward-based feedback. By changing the timing and amount of rewards, we aim to learn how these factors influence the ability to acquire and maintain new skills. This information may help improve behavioral interventions for individuals with IDD in the future. The study does not involve medications or procedures intended to change participants' health status.",[117,118],"Intellectual Disabilities (F70-F79)","Autism",[120,121,122],"Operant Conditioning","Neurodevelopmental disorders","Behavioral interventions","2025-08-21",{"date":125,"type":126},"2025-08-27","ACTUAL",{"date":128,"type":126},"2024-10-07",{"date":130,"type":112},"2026-08",{"name":5,"class":6},3]