Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube feeding. It will also look at tolerance, nutrition delivery, and safety.
The main questions it aims to answer are:
Do shorter feeding cycles (with fasting windows) reduce ICU length of stay?
Do they lower the risk of infections like ventilator-associated pneumonia?
How do they affect calorie delivery, blood sugar control, and gastrointestinal tolerance?
Researchers will compare:
Continuous 24-hour feeding (standard care)
20-hour feeding with a 4-hour fasting window
18-hour feeding with a 6-hour fasting window
Participants will:
Be critically ill adults in the ICU who require at least 7 days of enteral feeding
Be randomized to one of the three feeding schedules
Receive daily monitoring of calories, protein, blood sugar, and GI tolerance
Have outcomes measured, including ICU length of stay, infections, metabolic control, and feeding tolerance
Patients aged ≥ 18 years.
Patients expected to require enteral nutrition (EN) for ≥ 7 days.
Critically ill, mechanically ventilated patients in the ICU.
New patients initiating EN in the critical care unit.
Active GI bleeding.
Progressive GI disease.
Recent GI tract resection.
Indication for a special diet formula.
Hamad Medical Corporation
Lead sponsor