[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619426":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":29,"centralContacts":37,"locations":43,"responsibleParty":67,"collaborators":29,"id":71,"slug":29,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":29,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":29,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":29,"overallStatus":45,"whyStopped":29,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Group C (Control Group)","PLACEBO_COMPARATOR","Patients will be receive one oral placebo capsule the evening before surgery, one oral placebo capsule 2 hours prior to surgery, and one oral placebo capsule in the morning and one in the evening for 3 consecutive days postoperatively.",[13],"Other: Placebo capsule",{"label":15,"type":16,"description":17,"interventionNames":18},"Group M (Melatonin Group)","EXPERIMENTAL","Participants will receive one 5 mg oral melatonin capsule the evening before surgery, one 5 mg oral melatonin capsule 2 hours prior to surgery, and one oral placebo capsule in the morning, and one 5 mg oral melatonin capsule in the evening, daily for 3 consecutive days postoperatively.",[19],"Drug: Melatonin capsule",{"label":21,"type":16,"description":22,"interventionNames":23},"Group P (Pregabalin Group)","Participants will receive one 75 mg oral pregabalin capsule the evening before surgery, one 75 mg oral pregabalin capsule 2 hours prior to surgery, and one 75 mg oral pregabalin capsule in the morning, and another in the evening, daily for 3 consecutive days postoperatively.",[24],"Drug: Pregabalin capsule",[26,30,34],{"type":6,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"Placebo capsule",[9],null,{"type":31,"name":32,"description":17,"armGroupLabels":33,"otherNames":29},"DRUG","Melatonin capsule",[15],{"type":31,"name":35,"description":22,"armGroupLabels":36,"otherNames":29},"Pregabalin capsule",[21],[38],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"Ahmed H Ayad, MSc","CONTACT","00201009598637","Ahmed.hamdy@med.tanta.edu.eg",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Tanta","El-Gharbia","31527","Egypt",{"type":51,"coordinates":52},"Point",[53,54],31.00192,30.78847,{"lat":54,"lon":53},[57,58,61,63,65],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},{"name":59,"role":60,"phone":29,"phoneExt":29,"email":29},"Shaimaa F Mostafa, MD","SUB_INVESTIGATOR",{"name":62,"role":60,"phone":29,"phoneExt":29,"email":29},"Gehan M Morsy, MD",{"name":64,"role":60,"phone":29,"phoneExt":29,"email":29},"Laila A Elahwal, MD",{"name":66,"role":60,"phone":29,"phoneExt":29,"email":29},"Ahmed E Abo Elhkair, MD",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Ahmed Hamdy Said Ayad","Assistant lecturer of Anesthesia, Surgical Intensive Care and Pain Medicine, Tanta University, Tanta, Egypt.","100619426",false,"NCT07344467","Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery","Effect of Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery: A Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 21-60 years old.\n* Both sexes.\n* Patients of American Society of Anesthesiologists (ASA) physical status I \\& II.\n* Undergoing elective spine surgery.\n\nExclusion Criteria:\n\n* Patient refusal.\n* History of allergic reactions to melatonin or pregabalin.\n* Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block).\n* Patients with kidney disease with (plasma creatinine level \\> 1.5mg\u002Fdl).\n* Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal).\n* Psychological and cognitive disorders; dementia; major depression.\n* Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.","ALL","21 Years","60 Years",{"count":81,"type":82},105,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.",[88,89,90,91,92,93],"Oral","Melatonin","Pregabalin","Postoperative Pain","Anxiety","Spine Surgery","2026-01-17",{"date":96,"type":97},"2026-01-21","ACTUAL",{"date":94,"type":97},{"date":100,"type":82},"2027-06-01",{"name":5,"class":6},1]