[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577638":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":16,"studyPopulation":20,"armGroups":21,"interventions":31,"overallOfficials":16,"centralContacts":36,"locations":47,"responsibleParty":65,"collaborators":16,"id":67,"slug":16,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":16,"enrollmentInfo":77,"targetDuration":16,"studyType":80,"phases":16,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":50,"whyStopped":16,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Istituto Auxologico Italiano","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Orexin A promoter methylation","Percentage of Orexin A promoter methylation","Baseline",{"measure":14,"description":15,"timeFrame":12},"Orexin B promoter methylation","Percentage of Orexin B promoter methylation",null,{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":18,"timePerspective":19,"maskingInfo":16},"COHORT","CROSS_SECTIONAL","30 young women (\\> 18 years old), hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), for each of whom a diagnosis of AN will be formulated based on the DSM-criteria 5 (Diagnostic and Statistical Manual of Mental Disorders 5; American Psychiatric Association, 2013).\n\nFor each patient, a woman of comparable age, with a BMI between 18.5 and 24.9 kg\u002Fm2, is enrolled in the control group.",[22,27],{"label":23,"type":16,"description":24,"interventionNames":25},"Anorexia Nervosa","Young women with Anorexia Nervosa, hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy,",[26],"Other: Blood samples and Questionnaires",{"label":28,"type":16,"description":29,"interventionNames":30},"Normal weight","Young women of comparable age with Body Mass Index between 18.5 and 24.9 kg\u002Fm2",[26],[32],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":16},"Blood samples and Questionnaires","Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires:\n\nEating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \\& Ostberg questionnaire",[23,28],[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Alessandro Sartorio, MD","CONTACT","+390261911","2426","sartorio@auxologico.it",{"name":44,"role":39,"phone":40,"phoneExt":45,"email":46},"Luca Grappiolo, Dr.","2894","luca.grappiolo@auxologico.it",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Istituto Auxologico Italiano IRCCS, Site Piancavallo","RECRUITING","Oggebbio","Verbania","28824","Italy","IT",{"type":57,"coordinates":58},"Point",[59,60],8.64663,45.99088,{"lat":60,"lon":59},[63],{"name":38,"role":39,"phone":64,"phoneExt":41,"email":42},"+39-02619111",{"type":66,"investigatorFullName":16,"investigatorTitle":16,"investigatorAffiliation":16,"oldNameTitle":16,"oldOrganization":16},"SPONSOR","100577638",false,"NCT06800898","Orexin Gene in Anorexia Nervosa","The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality","ORESSANNE","Patients with Anorexia Nervosa:\n\nInclusion Criteria:\n\n* Female sex\n* Age 18 years and older\n* Anorexia Nervosa\n* Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy\n\nExclusion Criteria:\n\n* Absence of signed informed consent\n\nControl group:\n\nInclusion Criteria:\n\n* Female sex\n* Age 18 years and older\n* Body Mass Index between 18.5 and 24.9 kg\u002Fm2\n\nExclusion Criteria:\n\n* Absence of signed informed consent\n* Presence of any physical and mental pathology",true,"FEMALE","18 Years",{"count":78,"type":79},60,"ESTIMATED","OBSERVATIONAL","The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.",[23],[84,85,86,87,88,89],"Orexins","Methylation","Epigenetics","Psychiatric comorbidities","Eating disorder","Quality of sleep","2026-03-25",{"date":92,"type":93},"2026-03-30","ACTUAL",{"date":95,"type":93},"2024-06-19",{"date":97,"type":79},"2026-06-30",{"name":5,"class":6},1]