[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100441127":3},{"organization":4,"outcomesModule":7,"designInfo":35,"detailedDescription":38,"studyPopulation":39,"armGroups":40,"interventions":49,"overallOfficials":55,"centralContacts":59,"locations":64,"responsibleParty":97,"collaborators":101,"id":103,"slug":34,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":34,"studyType":116,"phases":34,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":67,"whyStopped":34,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},{"fullName":5,"class":6},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":34},[9],{"measure":10,"description":11,"timeFrame":12},"functional independence","mRS 0-2","3 month",[14,17,21,24,28,31],{"measure":15,"description":16,"timeFrame":12},"excellent functional independence","mRS 0-1",{"measure":18,"description":19,"timeFrame":20},"early therapeutic response","defined as a decrease in the NIHSS score of ≥10 from baseline or an NIHSS score of 0 or 1","on day 5, 6, or 7 of hospitalization or at discharge if it occurred before day 5",{"measure":22,"description":23,"timeFrame":12},"Mortality","Mortality of 3 month after stoke onset",{"measure":25,"description":26,"timeFrame":27},"hemorrhagic transformation","according to European Cooperative Acute Stroke Study II criteria","24 hours after treatment",{"measure":29,"description":30,"timeFrame":27},"Symptomatic intracerebral hemorrhage (sICH)","an increase of ≥4 points on the National Institutes of Health Stroke Scale (NIHSS) according to Heidelberg Bleeding Classification",{"measure":32,"description":33,"timeFrame":27},"malignant infarction","defined as infarct lesions with significant space-occupying mass effect with over 1\u002F2 affected middle cerebral artery territory with imaging signs of herniation and\u002For and clinical signs of herniation requiring decompressive hemicraniectomy and\u002For leading to death due to direct implications of stroke",null,{"allocation":34,"interventionModel":34,"interventionModelDescription":34,"primaryPurpose":34,"observationalModel":36,"timePerspective":37,"maskingInfo":34},"COHORT","PROSPECTIVE","For acute ischemic stroke (AIS) patients with large vessel occlusion in the anterior circulation receieved successful reperfusion, in situ ischemic postconditioning (ISIPC) was performed immediately after successful reperfusion with 5 circules of balloon inflations in the ipsilateral internal carotid artery, each circulation includes inflation lasting 15 seconds followed by 15 seconds of deflation.","Patients were treated according to national guidelines for treatment of AIS, including intravenous thrombolysis, if indicated. Thrombectomy were performed according to standard techniques. The method of endovascular therapy was selected at the discretion of treating physicians and could include stent retriever and\u002For catheter aspiration.",[41,46],{"label":42,"type":34,"description":43,"interventionNames":44},"rapid local ischemic postconditioning (RL-IPostC) group","RL-IPostC is performed immediately after successful reperfusion with 5 circules of balloon inflations in the ipsilateral internal carotid artery, each circulation includes inflation lasting 15 seconds followed by 15 seconds of deflation.",[45],"Procedure: rapid local ischemic postconditioning (RL-IPostC)",{"label":47,"type":34,"description":48,"interventionNames":34},"control group","no intervention was provided after successful reperfusion",[50],{"type":51,"name":52,"description":53,"armGroupLabels":54,"otherNames":34},"PROCEDURE","rapid local ischemic postconditioning (RL-IPostC)","with 5 circules of balloon inflations in the ipsilateral internal carotid artery, each circulation includes inflation lasting 15 seconds followed by 15 seconds of deflation",[42],[56],{"name":57,"affiliation":5,"role":58},"Yueqi Zhu, PhD","STUDY_CHAIR",[60],{"name":57,"role":61,"phone":62,"phoneExt":34,"email":63},"CONTACT","+86-21-18930177565","zhuyueqi@hotmail.com",[65,83],{"facility":66,"status":67,"city":68,"state":69,"zip":34,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"Zhangzhou Municipal Hospital of Fujian Province","RECRUITING","Zhangzhou","Fujian","China","CN",{"type":73,"coordinates":74},"Point",[75,76],117.65556,24.51333,{"lat":76,"lon":75},[79],{"name":80,"role":61,"phone":81,"phoneExt":34,"email":82},"Wenhuo Chen, MD","+86-596-2082950","doctorwwenhuo@126.com",{"facility":84,"status":67,"city":85,"state":34,"zip":86,"country":70,"countryCode":71,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","Shanghai","200233",{"type":73,"coordinates":88},[89,90],121.45806,31.22222,{"lat":90,"lon":89},[93],{"name":94,"role":61,"phone":95,"phoneExt":34,"email":96},"Jiangshan Deng, PhD","02164369181","johnson120@126.com",{"type":98,"investigatorFullName":99,"investigatorTitle":100,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Yueqi Zhu","Associated dean of the radiology",[102],{"name":66,"class":6},"100441127",false,"NCT05024292","Oriental Research AlliaNce of Acute Ischemic Stroke Given Endovascular Treatment","Oriental Research Alliance of Acute Ischemic Stroke Given Endovascular Treatment: Technique Feasibility, Safety and Neuroprotective Effects of in Situ Ischemic Postconditioning in Patients Underwent Successful Endovascular Thrombectomy","ORANGE","Inclusion Criteria:\n\n1. Adult (age ≥ 18 to 95 years) patients with an occlusion of the internal carotid artery or M1 or M2 segment of the middle cerebral artery,;\n2. Patients with a score of at least 6 on the National Institutes of Health Stroke Scale (NIHSS) at admission and a score of 0 or 1 on the modified Rankin scale before the onset of stroke;\n3. Patients with a score of at least 6 on the Alberta Stroke Program Early CT score (ASPECTS) value;\n4. Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital\n5. The modified thrombolysis in cerebral infarction (mTICI) scale 2b to 3 achieved in the infarct-related artery after the last thrombectomy attempt\n\nExclusion Criteria:\n\n1. Stoke of large artery atherosclerotic origin or other determined factors (such as dissection) or tandem occlusion;\n2. Patients underwent rescue angioplasty or stenting after thrombectomy","ALL","18 Years","95 Years",{"count":114,"type":115},160,"ESTIMATED","OBSERVATIONAL","To determine the safety and efficacy of in situ ischemic postconditioning immediately after successful reperfusion in AIS patients underwnet EVT.",[119],"Ischemic Stroke",[121,122,123,124],"acute ischemic stroke","thrombectomy","thrombolysis","outcome","2023-07-10",{"date":127,"type":128},"2023-07-12","ACTUAL",{"date":130,"type":128},"2022-01-01",{"date":132,"type":115},"2027-04",{"name":5,"class":6},2]