Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Health Network, Toronto
About this trial
PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure (AHRF) supported with invasive mechanical ventilation.
Eligibility criteria
Qualifiers
None
Disqualifiers
Contraindication to neuromuscular blockade (allergy, history of malignant hyperthermia)
Contraindication to ulnar nerve stimulation (bilateral peripheral neuropathy, skin burns on both wrists)
Previous history of a formally diagnosed neuromuscular disorder
Trial design
Treatments tested in this trial
- Cisatracurium
Treatment groups
23 Participants
are divided into 1 treatment groupLocations
1University Health NetworkM5G 2N2, TorontoOntario, Canada
Sponsors and collaborators
University Health Network, Toronto
Lead sponsor
Source ClinicalTrials.gov