[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622284":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":27,"studyPopulation":28,"armGroups":29,"interventions":40,"overallOfficials":23,"centralContacts":50,"locations":60,"responsibleParty":88,"collaborators":23,"id":90,"slug":23,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":23,"eligibilityCriteria":95,"healthyVolunteers":91,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":102,"studyType":103,"phases":23,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":81,"whyStopped":23,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Ankara Training and Research Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Change in Knee Pain Intensity (Visual Analog Scale [VAS])","Change in Knee Pain Intensity (Visual Analog Scale \\[VAS\\]) Change from baseline in knee pain intensity measured using the Visual Analog Scale (VAS), a 100-mm horizontal line anchored at 0 = no pain and 100 = worst imaginable pain; higher scores indicate worse pain.","Baseline, 1 month, 3 months, and 6 months",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Change in Functional Status (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC])","Change from baseline in WOMAC total score (and\u002For subscales: pain, stiffness, and physical function) assessing knee osteoarthritis-related symptoms. The WOMAC consists of 24 items with a total score ranging from 0 to 96; higher scores indicate worse symptoms and worse functional status.",{"measure":18,"description":19,"timeFrame":12},"Change in Knee Range of Motion","Change in knee joint range of motion measured using goniometry.",{"measure":21,"description":22,"timeFrame":12},"Change in Quadriceps Muscle Strength","Change in quadriceps muscle strength assessed by manual muscle testing.",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"COHORT","PROSPECTIVE","Knee osteoarthritis is a common degenerative joint disease associated with chronic pain, functional limitation, and reduced quality of life. Various non-surgical treatment modalities have been used to manage symptoms; however, the effectiveness of these treatments may be limited due to the complex pain mechanisms involved in osteoarthritis.\n\nPerineural injection therapy has gained increasing attention as a minimally invasive treatment option targeting neurogenic inflammation around peripheral sensory nerves. Perineural 5% dextrose injection is thought to reduce pain by modulating neurogenic inflammation, while local anesthetic injections are commonly used in clinical practice for symptomatic relief.\n\nThis study is designed as a prospective observational cohort study conducted in a routine clinical setting. Patients aged 40 to 65 years with symptomatic knee osteoarthritis who are treated with perineural injections as part of standard care will be included. The choice of injectate (perineural 5% dextrose or perineural local anesthetic) will be determined based on clinical considerations and patient preference; no randomization or protocol-driven assignment will be performed.\n\nPain severity will be evaluated using the Visual Analog Scale (VAS). Functional status will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Additional clinical parameters, including knee range of motion measured by goniometry and quadriceps muscle strength assessed by manual muscle testing, will also be recorded. Assessments will be performed at baseline, and at 1, 3, and 6 months following treatment.\n\nClinical outcomes of the two treatment groups will be compared to evaluate changes in pain and functional status over time. The findings of this study are expected to contribute real-world evidence regarding the clinical effectiveness of perineural 5% dextrose and local anesthetic injections in the management of symptomatic knee osteoarthritis.","Adult patients aged 40 to 65 years with symptomatic knee osteoarthritis who are receiving perineural injection therapy as part of routine clinical care. Eligible participants include both male and female patients who meet the predefined inclusion and exclusion criteria and are able to provide written informed consent.",[30,35],{"label":31,"type":23,"description":32,"interventionNames":33},"Perineural 5% Dextrose Group","Patients with symptomatic knee osteoarthritis receiving perineural 5% dextrose injections as part of routine clinical care.",[34],"Procedure: Perineural 5% Dextrose Injection",{"label":36,"type":23,"description":37,"interventionNames":38},"Perineural Local Anesthetic Group","Patients with symptomatic knee osteoarthritis receiving perineural local anesthetic injections as part of routine clinical care.",[39],"Procedure: Perineural Local Anesthetic Injection",[41,46],{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":23},"PROCEDURE","Perineural 5% Dextrose Injection","Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.",[31],{"type":42,"name":47,"description":48,"armGroupLabels":49,"otherNames":23},"Perineural Local Anesthetic Injection","Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.",[36],[51,56],{"name":52,"role":53,"phone":54,"phoneExt":23,"email":55},"Nadide Koca, M.D.","CONTACT","+905376843434","nadide.koca@gmail.com",{"name":57,"role":53,"phone":58,"phoneExt":23,"email":59},"Hakan Genç, PROF. M.D.","05359780666","hakangenc06@hotmail.com",[61,80],{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":23,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230","NOT_YET_RECRUITING","Ankara","Altindag","06230","Turkey (Türkiye)",{"type":69,"coordinates":70},"Point",[71,72],32.85427,39.91987,{"lat":72,"lon":71},[75,77,78],{"name":52,"role":53,"phone":76,"phoneExt":23,"email":55},"05376843434",{"name":23,"role":53,"phone":23,"phoneExt":23,"email":55},{"name":52,"role":79,"phone":23,"phoneExt":23,"email":23},"PRINCIPAL_INVESTIGATOR",{"facility":62,"status":81,"city":64,"state":65,"zip":66,"country":67,"countryCode":23,"cosmosGeoPoint":82,"geoPoint":84,"contacts":85},"RECRUITING",{"type":69,"coordinates":83},[71,72],{"lat":72,"lon":71},[86],{"name":87,"role":53,"phone":76,"phoneExt":23,"email":55},"Nadide Koca",{"type":79,"investigatorFullName":87,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Principal Investigator, M.D., Physical Medicine and Rehabilitation","100622284",false,"NCT07381621","Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis","A Prospective Evaluation of the Clinical Effectiveness of Perineural Dextrose and Conventional Local Anesthetic Injections in Patients With Symptomatic Knee Osteoarthritis","Inclusion Criteria:\n\n* Symptomatic knee osteoarthritis\n* Clinical\u002Fradiological diagnosis\n* Knee pain ≥ 3 months\n* Written informed consent\n\nExclusion Criteria:\n\n* Prior knee surgery\n* Recent intra-articular injection\n* Inflammatory rheumatic disease\n* Severe systemic or neurological disease\n* Pregnancy or breastfeeding","ALL","40 Years","65 Years",{"count":100,"type":101},86,"ESTIMATED","6 Months","OBSERVATIONAL","This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.",[106],"Knee Osteoarthritis",[108,109,110,111,112,113],"Perineural Injection","Dextrose Injection","Local Anesthetic Injection","Pain","WOMAC","Observational Study","2026-04-16",{"date":116,"type":117},"2026-04-17","ACTUAL",{"date":119,"type":117},"2026-02-02",{"date":121,"type":101},"2026-08",{"name":5,"class":6},2]