[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641287":3},{"organization":4,"outcomesModule":7,"designInfo":40,"detailedDescription":47,"studyPopulation":39,"armGroups":48,"interventions":66,"overallOfficials":79,"centralContacts":83,"locations":89,"responsibleParty":104,"collaborators":39,"id":107,"slug":39,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":108,"sex":114,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":39,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":92,"whyStopped":39,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"Baskent University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":39},[9],{"measure":10,"description":11,"timeFrame":12},"Exercise Capacity","Exercise capacity will be assessed using the 6-Minute Walk Test (6MWT)","Baseline and after 8 week",[14,18,21,24,27,30,33,36],{"measure":15,"description":16,"timeFrame":17},"Change in Peripheral Muscle Strength","Peripheral muscle strength will be assessed using handheld dynamometry for upper and lower extremity muscle groups and reported in Newton (N).","Baseline and after 8 weeks",{"measure":19,"description":20,"timeFrame":17},"Change in Hand Grip Strength","Hand grip strength will be assessed using a hand dynamometer and reported in kilograms (kg).",{"measure":22,"description":23,"timeFrame":17},"Change in Diabetes Quality of Life Questionnaire Score","Change in the Turkish version of the Diabetes Quality of Life Questionnaire (DQOL) total score and subscale scores from baseline to 8 weeks will be evaluated. The DQOL consists of 45 items assessing treatment satisfaction, psychological impact, concerns about future effects of diabetes, and social\u002Fvocational concerns. Each item is scored on a 1-5 scale, and higher scores indicate better diabetes-related quality of life.",{"measure":25,"description":26,"timeFrame":17},"Change in Body Fat Percentage","Body fat percentage (%) will be assessed using bioelectrical impedance analysis (BIA).",{"measure":28,"description":29,"timeFrame":17},"Change in Skeletal Muscle Mass","Skeletal muscle mass (kg) will be assessed using bioelectrical impedance analysis (BIA).",{"measure":31,"description":32,"timeFrame":17},"Change in Resting Metabolic Rate","Resting metabolic rate (kcal\u002Fday) will be assessed using indirect calorimetry (COSMED Fitmate Pro, Rome, Italy).",{"measure":34,"description":35,"timeFrame":17},"Change in Hemoglobin A1c (HbA1c)","Glycemic control will be assessed by measuring glycated hemoglobin (HbA1c) levels (%).",{"measure":37,"description":38,"timeFrame":17},"Change in Fasting Blood Glucose","Glycemic control will be assessed by measuring fasting blood glucose levels (mg\u002FdL).",null,{"allocation":41,"interventionModel":42,"interventionModelDescription":43,"primaryPurpose":44,"observationalModel":39,"timePerspective":39,"maskingInfo":45},"RANDOMIZED","PARALLEL","Participants will be assigned to one of three parallel groups: non-linear periodization-based strength training, linear periodization-based strength training, or control.","TREATMENT",{"masking":46,"maskingDescription":39,"whoMasked":39},"NONE","Type 2 diabetes mellitus is associated with reduced exercise capacity, decreased muscle strength, impaired quality of life, and metabolic dysfunction. Exercise training is recommended as an important component of diabetes management; however, the comparative effectiveness of different strength training periodization approaches remains unclear.\n\nThis randomized controlled trial aims to compare the effects of non-linear periodization and linear periodization strength training programs in individuals with type 2 diabetes mellitus. Participants will be randomized into three groups: a non-linear periodization training group, a linear periodization training group, and a control group receiving usual care.\n\nThe intervention will be conducted for 8 weeks, three times per week. Outcomes including exercise capacity, muscle strength, body composition, quality of life, and metabolic parameters will be evaluated before and after the intervention period.",[49,55,60],{"label":50,"type":51,"description":52,"interventionNames":53},"Non-linear Periodization Group","EXPERIMENTAL","Participants will receive non-linear periodization-based strength training three times per week for 8 weeks.",[54],"Behavioral: Non-linear Periodization-Based Strength Training",{"label":56,"type":51,"description":57,"interventionNames":58},"Linear Periodization Group","Participants will receive linear periodization-based strength training three times per week for 8 weeks.",[59],"Behavioral: Linear Periodization-Based Strength Training",{"label":61,"type":62,"description":63,"interventionNames":64},"Control Group","ACTIVE_COMPARATOR","Participants will receive usual care and no structured exercise intervention during the study period.",[65],"Other: Usual Care",[67,72,76],{"type":68,"name":69,"description":70,"armGroupLabels":71,"otherNames":39},"BEHAVIORAL","Non-linear Periodization-Based Strength Training","Participants will perform supervised non-linear periodization-based strength training three times per week for 8 weeks.",[50],{"type":68,"name":73,"description":74,"armGroupLabels":75,"otherNames":39},"Linear Periodization-Based Strength Training","Participants will perform supervised linear periodization-based strength training three times per week for 8 weeks.",[56],{"type":6,"name":77,"description":63,"armGroupLabels":78,"otherNames":39},"Usual Care",[61],[80],{"name":81,"affiliation":5,"role":82},"Neslihan Duruturk, PhD","PRINCIPAL_INVESTIGATOR",[84],{"name":85,"role":86,"phone":87,"phoneExt":39,"email":88},"Ayşegül Erkoç, PT","CONTACT","+90 553-301-36-73","erkcaysegl@gmail.com",[90],{"facility":91,"status":92,"city":93,"state":93,"zip":94,"country":95,"countryCode":39,"cosmosGeoPoint":96,"geoPoint":101,"contacts":102},"Baskent University Hospital","RECRUITING","Ankara","06790","Turkey (Türkiye)",{"type":97,"coordinates":98},"Point",[99,100],32.85427,39.91987,{"lat":100,"lon":99},[103],{"name":85,"role":86,"phone":87,"phoneExt":39,"email":88},{"type":82,"investigatorFullName":105,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"Neslihan Duruturk","Prof. Dr.","100641287",false,"NCT07659925","Periodization-Based Strength Exercise Training in İndividuals With Type 2 Diabetes","A Comparison of the Effects of Different Periodization-Based Strength Training Programs in Individuals With Type 2 Diabetes Mellitus","T2DM_NLP","Inclusion Criteria:\n\n* Adults aged between 18 to 65 years\n* Diagnosis of Type 2 Diabetes Mellitus (T2DM)\n* Not having participated in any structured exercise program within the last 6 months\n* Willingness to participate in the study and provide written informed consent\n\nExclusion Criteria:\n\n* Presence of nephropathy, retinopathy, or peripheral neuropathy\n* Presence of neurological, cognitive, or orthopedic disorders that may affect outcome measurements\n* Severe respiratory disease (Forced Expiratory Volume in the first second \\[FEV1\\] \\\u003C35% or Forced Vital Capacity \\[FVC\\] \\\u003C50%)\n* Presence of ischemic heart disease or peripheral arterial disease\n* History of any cardiovascular event within the last 6 months\n* Current malignancy","ALL","18 Years","65 Years",{"count":118,"type":119},48,"ESTIMATED","INTERVENTIONAL",[122],"NA","This randomized controlled study aims to compare the effects of different periodization-based strength training approaches in individuals with type 2 diabetes mellitus. Participants will be allocated to non-linear periodization, linear periodization, or control groups. The intervention program will be conducted for 8 weeks and will evaluate exercise capacity, muscle strength, quality of life, body composition, and metabolic parameters.",[125],"Type 2 Diabetes",[127,128,129,10,130,131,132,133],"Type 2 Diabetes Mellitus","Strength Training","Non-linear Periodization","Muscle Strength","Quality of Life","Linear Periodization","Resistance Training","2026-06-17",{"date":136,"type":137},"2026-06-22","ACTUAL",{"date":139,"type":137},"2026-05-01",{"date":141,"type":119},"2026-12",{"name":5,"class":6},1]