[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640087":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":14,"collaborators":18,"id":26,"slug":7,"hasResults":27,"nctId":28,"briefTitle":29,"officialTitle":30,"acronym":7,"eligibilityCriteria":31,"healthyVolunteers":27,"sex":32,"minAge":33,"maxAge":34,"enrollmentInfo":35,"targetDuration":7,"studyType":38,"phases":7,"briefSummary":39,"conditions":40,"keywords":43,"overallStatus":49,"whyStopped":7,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":7},{"fullName":5,"class":6},"Women's Hospital School Of Medicine Zhejiang University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Junfen Xu","CONTACT","+86 13567147767","xjfzu@zju.edu.cn",{"type":15,"investigatorFullName":16,"investigatorTitle":17,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Wang Hui","Professor",[19,21,23],{"name":20,"class":6},"Jiaxing Maternity and Child Health Care Hospital",{"name":22,"class":6},"Ningbo Women & Children's Hospital",{"name":24,"class":25},"Zhejiang PuLuoTing Health Technology Co., Ltd.","UNKNOWN","100640087",false,"NCT07606677","Peripheral Blood CyTOF Immune Model for Cervical Lesion Detection in HPV16\u002F18+ Women","Mass Cytometry-based Peripheral Blood Immune Model for Accurate Detection of Cervical Lesions in HPV16\u002F18-positive Women: a Multicenter Study","Inclusion Criteria:\n\n* Availability of cervical cytology results\n* Consent to colposcopy and cervical biopsy\n* Signed informed consent\n\nExclusion Criteria:\n\n* Confirmed diagnosis of CIN2 or worse\n* Prior cervical ablation, cervical conization, chemoradiotherapy, or immunotherapy\n* Other malignancy within the past 2 years not in complete remission\n* Presence of other systemic immune disease or active infection\n* Pregnancy or lactation\n* Inability to comply with follow-up and examinations\n* Inability to comply with study procedures, restrictions, and requirements, as determined by the investigator","FEMALE","25 Years","65 Years",{"count":36,"type":37},1465,"ESTIMATED","OBSERVATIONAL","This prospective, multicenter cohort study will recruit eligible HPV16\u002F18-positive women from three tertiary hospitals in China. Peripheral blood samples and clinical data (cytology, HPV genotyping, colposcopy-directed biopsy) will be collected, followed by standardized mass cytometry (CyTOF) to develop and evaluate an immune model across cervical lesion grades.",[41,42],"CIN 2\u002F3","Cervical Cancer (Early Detection)",[44,45,46,47,48],"cervical cancer","Cervical Intraepithelial Neoplasia","HPV16\u002F18","Mass cytometry","Immune model","NOT_YET_RECRUITING","2026-05-18",{"date":52,"type":53},"2026-05-26","ACTUAL",{"date":55,"type":37},"2026-05-15",{"date":57,"type":37},"2028-03-31",{"name":5,"class":6}]