[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596594":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":10,"id":53,"slug":10,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"European Institute of Oncology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prostate patients",null,"prostate patients undergoing RT",[13],"Other: prostate patient",{"label":15,"type":10,"description":16,"interventionNames":17},"breast patients","breast patients undergoing RT",[18],"Other: breast patients",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"prostate patient","patients with prostate cancer treated with RT at IEO",[9],{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":10},"patients with breast cancer treated with RT at IEO",[15],[28],{"name":29,"affiliation":5,"role":30},"Giulia Marvaso","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Giulia Marvaso, MD","CONTACT","+390294372696","giulia.marvaso@ieo.it",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":41,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Milan","Italy","20141",{"type":44,"coordinates":45},"Point",[46,47],9.18951,45.46427,{"lat":47,"lon":46},[50],{"name":29,"role":34,"phone":35,"phoneExt":10,"email":36},{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100596594",false,"NCT07047495","Personalization of External Beam Radiation Therapy in Localised Tumours","MINIONS - Patient-specific Microstructural and radIobiological Model for persoNalised External Beam radiatION Therapy in Localised tumourS","MINIONS","Inclusion criteria for prostate patients:\n\n* Unifocal infiltrating ductal breast carcinoma, non-special histotype\n* clinical stage T1-T2,N0\n* No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent.\n* Patients aged \\>18 years\n* Good general condition (ECOG 0-2)\n* Expected active treatment (crioablation or surgery or radiotherapy ).\n\nExclusion Criteria:\n\n* Exclusion criteria for prostate patients:\n\n  * Nodule involvement and metastasis (cN1 and\u002For cM1)\n  * Concomitant inflammation of the intestine\n  * Significant systemic diseases or ongoing oral anticoagulant therapy\n  * Non-compliance of dose constraints in the treatment plan\n  * Previous invasive cancer, unless the patient has had no disease for at least 3 years\n  * Mental disorders that cannot ensure valid informed consent\n\nExclusion criteria for breast patients:\n\n* Histology other than non-special histotype and non-epithelial tumors (sarcoma, lymphoma)\n* Male sex\n* High-risk mutation carrier patients\n* Bilateral breast cancer\n* synchronous distant metastases\n* Neoadjuvant therapy\n* autoimmune connective tissue diseases\n* previous radiotherapy to the chest\n* Mental disorders that cannot ensure valid informed consent\n* No previous thoracic radiotherapy","ALL","18 Years",{"count":63,"type":64},35,"ESTIMATED","OBSERVATIONAL","The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT).\n\nWithin the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples\u002Forganoids will be irradiated with RT for biological validation.",[68,69],"Breast Adenocarcinoma","Prostate Cancer (Adenocarcinoma)","2025-06-24",{"date":72,"type":73},"2025-07-02","ACTUAL",{"date":75,"type":64},"2025-07",{"date":77,"type":64},"2030-07",{"name":5,"class":6},1]