[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639574":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":36,"locations":42,"responsibleParty":61,"collaborators":35,"id":65,"slug":35,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":35,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":45,"whyStopped":35,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Shifa International Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Phenotype-Guided Meal Timing and Postprandial Walking","EXPERIMENTAL","Participants will receive personalized lifestyle guidance based on their CGM-derived circadian glycemic vulnerability phenotype. They will be advised to shift their highest glycemic-load meal away from their highest-vulnerability window and toward their lowest-vulnerability window, and to perform a 10-minute brisk walk within 30 minutes after the meal occurring in their highest-vulnerability window.",[13],"Behavioral: Phenotype-Guided Meal Timing and Postprandial Walking",{"label":15,"type":16,"description":17,"interventionNames":18},"Attention-Matched Sleep Hygiene and Step-Count Advice","ACTIVE_COMPARATOR","Participants will receive standardized sleep hygiene advice and general step-count guidance matched for contact time with the intervention group. They will not receive meal-timing advice, carbohydrate-timing advice, or postprandial walking instructions.",[19],"Behavioral: Sleep Hygiene and Step-Count Advice",[21,28],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Participants randomized to this arm will receive personalized lifestyle guidance based on their CGM-derived circadian glycemic vulnerability phenotype. During the 10-day run-in period, continuous glucose monitoring, wrist actigraphy, and timestamped meal-photo logs will be used to identify the time window in which each participant has the greatest postprandial glucose exposure. Participants will be advised to shift their highest glycemic-load meal away from their highest-vulnerability window and toward their lowest-vulnerability window where feasible. They will also be instructed to perform a 10-minute brisk walk within 30 minutes after the meal occurring in their highest-vulnerability window on at least 5 days per week. The intervention will be delivered through structured dietitian counseling sessions and brief weekly check-in calls. No calorie restriction, prescribed macronutrient diet, or weight-loss target will be imposed.",[9],[26,27],"Phenotype-Guided Meal Timing","Postprandial Walking",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Sleep Hygiene and Step-Count Advice","Participants randomized to the active comparator arm will receive standardized sleep hygiene and general physical activity guidance matched for contact time with the intervention arm. Sleep hygiene advice will include maintaining regular sleep and wake times, aiming for adequate sleep duration, and reducing screen exposure before bedtime. Participants will also be advised to increase their average daily step count by approximately 10% above their run-in baseline, with steps distributed freely throughout the day. This arm will not include any advice on meal timing, carbohydrate timing, glycemic vulnerability windows, or postprandial walking. The intervention will be delivered through structured dietitian counseling sessions and brief weekly check-in calls.",[15],[33,34],"Sleep Hygiene","Step-Count Advice",null,[37],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},"Nadia Hussain, MD, PhD","CONTACT","0505440153","nadia.hussain@aau.ac.ae",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Shifa International hospital","RECRUITING","Lahore","Shaikhupura","50","Pakistan",{"type":51,"coordinates":52},"Point",[53,54],74.35071,31.558,{"lat":54,"lon":53},[57],{"name":58,"role":39,"phone":59,"phoneExt":35,"email":60},"Saima T Abass, MD, PhD","00923206503200","saimaabasstahammal@gmail.com",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Saima Abass Tahammal","Medical director","100639574",false,"NCT07618663","Personalized Meal Timing and Walking Based on Glucose Patterns in Adults With Prediabetes","CGM-Phenotyped Circadian Glycemic Vulnerability Windows to Personalize Meal Timing and Postprandial Activity in Prediabetes : A Randomized Controlled Trial","CLOCK-PRIME","Inclusion Criteria:\n\n* Age 30 to 70 years\n* Prediabetes, defined as either:\n* HbA1c 5.7% to 6.4% within 3 months of screening, or\n* Fasting plasma glucose 100 to 125 mg\u002FdL on two separate occasions\n* Body mass index 23 to 40 kg\u002Fm²\n* Owns a smartphone compatible with study applications\n* Willing to wear a continuous glucose monitor and wrist activity monitor during the study period\n* Willing to record meals using timestamped meal-photo logging\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Current or prior diagnosis of type 1 diabetes or type 2 diabetes\n* Use of glucose-lowering medication within the past 3 months\n* Use of systemic corticosteroid medication within the past 3 months\n* Use of prescription weight-loss medication within the past 3 months\n* Current shift work\n* Transmeridian travel across more than 2 time zones within 4 weeks before enrollment\n* Known untreated or unstable sleep disorder, including obstructive sleep apnea, narcolepsy, or insomnia disorder\n* Pregnancy, planned pregnancy, or breastfeeding\n* Gastrointestinal disease or surgery likely to affect nutrient absorption\n* Current participation in a structured dietary or exercise intervention program\n* Estimated glomerular filtration rate less than 60 mL\u002Fmin\u002F1.73 m²\n* Inability or unwillingness to comply with continuous glucose monitoring, wrist actigraphy, meal logging, or study visits","ALL","30 Years","70 Years",{"count":76,"type":77},105,"ESTIMATED","INTERVENTIONAL",[80],"NA","This study will test whether glucose sensor data can be used to identify the time of day when adults with prediabetes are most likely to have high blood sugar after meals. Participants will first wear a continuous glucose monitor and wrist activity monitor and record meal times for 10 days. These data will be used to classify each participant's personal \"glycemic vulnerability window,\" such as morning, evening, or generally variable patterns.\n\nParticipants will then be randomly assigned to either personalized meal timing plus a short walk after their most vulnerable meal, or to an attention-matched control group receiving sleep hygiene and general step-count advice. The main outcome will be the change in post-meal glucose exposure during each participant's vulnerable window after 4 weeks.",[83,84,85],"Prediabetes","Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)","Prediabetes or Diabetes",[83,87,88,89,90],"Continuous Glucose Monitoring","Precision Lifestyle Medicine","Meal Timing","Glycemic Variability","2026-05-24",{"date":93,"type":94},"2026-06-01","ACTUAL",{"date":93,"type":77},{"date":97,"type":77},"2026-07-15",{"name":5,"class":6},1]