[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549172":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":39,"collaborators":7,"id":43,"slug":7,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":7,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":7,"studyType":55,"phases":7,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Fengmei Guo, PhD, MD","Nanjing Zhongda Hospital, Southeast University","STUDY_CHAIR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","+8613813841261","fmguo2022@163.com",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Zhiqian Zha, MM","+8615505083904","15505083904@163.com",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Zhongda Hospital, Southeast University","RECRUITING","Nanjing","Jiangsu","210009","China",{"type":31,"coordinates":32},"Point",[33,34],118.77778,32.06167,{"lat":34,"lon":33},[37],{"name":38,"role":15,"phone":16,"phoneExt":7,"email":17},"Fengmei Guo, Ph.D",{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Fengmei Guo","Director of Intensive Care Unit, Principal Investigator, Clinical Professor, Zhongda Hospital, Southeast University, China","100549172",false,"NCT06430554","Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability","Personalized Ventilatory Strategy Based on Ventilation-perfusion Mismatch and Lung Recruitability in Moderate-to-severe ARDS Patients","Inclusion Criteria:\n\n1. age ≥18 years\n2. Moderate-to-severe ARDS as per the 2023 ESICM definition\n3. Undergoing invasive mechanical ventilation\n4. Planned prone position based on the attending physicians' decisions\n5. Signed informed consent\n\nExclusion Criteria:\n\n1. age ≥85 years\n2. Pregnancy\n3. Severe hemodynamic instability (\\> 30% increase in vasopressors in the last 6 hours or norepinephrine \\> 0.5 µg\u002Fkg\u002Fmin)\n4. Clinically suspected elevated intracranial pressure (\\>18 mm Hg)\n5. Bronchopleural fistula\n6. Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)\n7. Severe hypernatremia (\\>170mmol\u002FL)\n8. Re-admission of patients already enrolled in this study, or patients who are participating in other studies","ALL","18 Years","85 Years",{"count":53,"type":54},40,"ESTIMATED","OBSERVATIONAL","This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.",[58,59,60],"Respiratory Distress Syndrome","Positive-Pressure Respiration","Mechanical Ventilation",[62],"Acute respiratory distress syndrome;Positive end expiratory pressure; Prone Position; Ventilation\u002Fperfusion matching.","2026-01-29",{"date":65,"type":66},"2026-02-03","ACTUAL",{"date":68,"type":66},"2024-06-08",{"date":70,"type":54},"2026-06-30",{"name":5,"class":6},1]