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Patients that receive morphine alone or morphine and midazolam as continuous infusion\n* Affiliated to a social security system\n\nExclusion Criteria:\n\n* Current weight \\\u003C 600g\n* Neonates under palliative care\n* Therapeutic hypothermia for perinatal anoxia\n* Neonates who underwent a surgical procedure during the past 72 hours\n* Neonates receiving concomitantly a paralytic or another drug for sedation or analgesia other than morphine or midazolam (except for paracetamol\u002Facetaminophen)\n* Parents refusing that their child participate","ALL","20 Weeks","45 Weeks",{"count":105,"type":106},180,"ESTIMATED","INTERVENTIONAL",[109],"NA","This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical ventilation, through PKPD modelling.",[112,113],"Sedation Complication","Mechanical Ventilation in 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