64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE)

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexMale
Age18+
SponsorClarity Pharmaceuticals Ltd

About this trial

The aim of this study is to determine the safety and efficacy of 67Cu-SAR-bisPSMA in participants with PSMA-expressing metastatic castrate resistant prostate cancer.

Eligibility criteria

Qualifiers

Signed informed consent;

≥18 years of age;

Eastern Cooperative Oncology Group performance status of 0 to 2;

Life expectancy >6 months;

Disqualifiers

Major surgery within 12 weeks prior to enrollment into the study;

Brain metastasis;

Histologic diagnosis of small cell or neuroendocrine prostate cancer;

Prior history of leukemia or Myelodysplastic Syndrome;

Trial design

Treatments tested in this trial

  • 64Cu-SAR-bisPSMA
  • 67Cu-SAR-bisPSMA

Treatment groups

54 Participants
are divided into 1 treatment group

Locations

7
California
Stanford Cancer Institute94305, Stanford United States
Louisiana
East Jefferson General Hospital70123, River Ridge United States
Michigan
BAMF Health49503, Grand Rapids United States
Minnesota
Mayo Clinic55905, Rochester United States

Sponsors and collaborators

Clarity Pharmaceuticals Ltd

Lead sponsor