[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450837":3},{"organization":4,"outcomesModule":7,"designInfo":95,"detailedDescription":101,"studyPopulation":94,"armGroups":102,"interventions":194,"overallOfficials":94,"centralContacts":211,"locations":217,"responsibleParty":1073,"collaborators":1075,"id":1078,"slug":94,"hasResults":1079,"nctId":1080,"briefTitle":1081,"officialTitle":1082,"acronym":94,"eligibilityCriteria":1083,"healthyVolunteers":1079,"sex":1084,"minAge":1085,"maxAge":94,"enrollmentInfo":1086,"targetDuration":94,"studyType":1089,"phases":1090,"briefSummary":1093,"conditions":1094,"keywords":1096,"overallStatus":590,"whyStopped":94,"lastUpdateSubmitDate":1126,"lastUpdatePostDateStruct":1127,"startDateStruct":1130,"completionDateStruct":1132,"leadSponsor":1134,"locationsCount":1135},{"fullName":5,"class":6},"DualityBio Inc.","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":43,"otherOutcomes":94},[9,13,17,21,24,27,30,33,36,40],{"measure":10,"description":11,"timeFrame":12},"Phase 1: Percentage of Participants with Dose-Limiting Toxicities (DLTs) as assessed by CTCAE v5.0.","Percentage of participants in Part 1 with DLTs","up to 21 days after C1D1",{"measure":14,"description":15,"timeFrame":16},"Phase 1: Percentage of participants with AEs in Part 1 graded according to NCI CTCAE v5.0","Percentage of Participants with Treatment Emergent Adverse Events (TEAEs) or Treatment Emergent Adverse Event of Special Interest include those \\>\u002F= G3 leading to dose reduction, interruption or discontinuation as assessed by CTCAE v5.0, abnormal vital signs, abnormal 12-lead ECGs, abnormal safety laboratory tests, abnormal ECOG PS, abnormal ECHO\u002FMUGA (LVEF).","Up to Safety Follow-Up visit, approximately 35 days post-treatment",{"measure":18,"description":19,"timeFrame":20},"Phase 1: Percentage of Participants with Serious Adverse Events (SAEs) as assessed by CTCAE v5.0.","Percentage of Participants with SAEs in Part 1 graded according to NCI CTCAE v5.0","Up to follow-up period, approximately 1 year post-treatment",{"measure":22,"description":23,"timeFrame":16},"Phase 1: Maximum Tolerated Dose (MTD) of DB-1303","MTD on the data collected during Part 1",{"measure":25,"description":26,"timeFrame":16},"Phase 1: Recommended Phase 2 Dose (RP2D) of DB-1303","RP2D of DB-1303 based on the data collected during Part 1",{"measure":28,"description":29,"timeFrame":20},"Percentage of participants with AEs in Part 2 graded according to NCI CTCAE v5.0","Phase 2: Percentage of Participants with Treatment Emergent Adverse Events (TEAEs) or Treatment Emergent Adverse Event of Special Interest include those \\>\u002F= G3 leading to dose reduction, interruption or discontinuation as assessed by CTCAE v5.0, abnormal vital signs, abnormal 12-lead ECGs, abnormal safety laboratory tests, abnormal ECOG PS, abnormal ECHO\u002FMUGA (LVEF).",{"measure":31,"description":32,"timeFrame":20},"Phase 2: Percentage participants with Serious Adverse Events (SAEs) as assessed by CTCAE v5.0.","Percentage of participants with SAEs in Part 2 graded according to NCI CTCAE v5.0",{"measure":34,"description":35,"timeFrame":20},"Phase 2: Percentage of Objective Response Rate (ORR) as assessed by RECIST 1.1.","The percentage of subjects who had a best response of CR or PR, for Part 2 only which was maintained ≥4 weeks.",{"measure":37,"description":38,"timeFrame":39},"Phase 2 (Dose Expansion 10 only): To evaluate the effect of ritonavir on DB-1303 and P1003 PK in subjects with HER2-expressing, HER2-amplified, or HER2-mutated advanced solid malignant tumors","Maximum observed plasms concentration (Cmax) and Area under the concentration-time curve from 0 to infinity of DB-1303 and P1003 (+\u002F- Ritonavir)","up to safety follow-up visit, approx. 35 days post-treatment",{"measure":41,"description":42,"timeFrame":39},"Phase 2 (Dose Expansion 10 only): To evaluate the effect of itraconazole on DB-1303 and P1003 PK in subjects with HER2-expressing, HER2-amplified, or HER2-mutated advanced solid malignant tumors.","Maximum observed plasms concentration (Cmax) and Area under the concentration-time curve from 0 to infinity of DB-1303 and P1003 (+\u002F- Itraconazole)",[44,48,51,54,57,60,63,66,69,72,76,79,82,85,88,91],{"measure":45,"description":46,"timeFrame":47},"Phase 1 & Phase 2: Pharmacokinetic-AUC","Area under the concentration-time curve from time 0 to infinity of DB-1303","Up to safety follow up visit, approx. 35 days post-treatment",{"measure":49,"description":50,"timeFrame":47},"Phase 1 & Phase 2: Pharmacokinetic-Cmax","Maximum observed plasma concentration (Cmax) of DB-1303",{"measure":52,"description":53,"timeFrame":47},"Phase 1 & Phase 2: Pharmacokinetic-Tmax","Time to Cmax of DB-1303",{"measure":55,"description":56,"timeFrame":47},"Phase 1 & Phase 2: Pharmacokinetic-T1\u002F2","Terminal elimination half-life",{"measure":58,"description":59,"timeFrame":47},"Phase 1 & Phase 2: Pharmacokinetic-Ctrough","Trough concentration of DB-1303",{"measure":61,"description":62,"timeFrame":47},"Phase 1 & Phase 2: Pharmacodynamics-ADA","Data gathered from blood to determine Levels of anti-drug antibody (ADA) against DB 1303 in serum compared to baseline.",{"measure":64,"description":65,"timeFrame":20},"Phase 1 & 2: Disease Control Rate (DCR) as assessed by RECIST 1.1","Proportion of participants who had a best response rating of CR or PR, or SD using RECIST V1.1.",{"measure":67,"description":68,"timeFrame":20},"Phase 1 & 2: Duration of Response (DoR) as assessed by RECIST 1.1","The duration of time from date of first CR or PR to date of progressive disease or death due to any cause, whichever comes first using RECIST V1.1",{"measure":70,"description":71,"timeFrame":20},"Phase 1 & 2: Time to Response (TTR) as assessed by RECIST 1.1","The duration of time when receiving the first dose of study drug to the first date that is evaluated as either CR or PR using RECIST V1.1",{"measure":73,"description":74,"timeFrame":75},"Phase 2: Time on Therapy","The duration of time from participant receiving first dose of study drug to the last dose + 21 days","Up to 21 days after the participant's last dose",{"measure":77,"description":78,"timeFrame":20},"Phase 2: Percent change in target lesions as assessed by RECIST 1.1","The percent change in the participant's target lesions from baseline to last study scan using RECIST V1.1",{"measure":80,"description":81,"timeFrame":20},"Phase 1 and 2 Cohort b only: Progression-Free Survival","Time from subject receiving the first dose to disease progression or death by any cause",{"measure":83,"description":84,"timeFrame":20},"Phase 1 and 2 Cohort b only: Overall Survival","Time from subject receiving the first dose to death by any cause",{"measure":86,"description":87,"timeFrame":20},"Phase I: Percentage of Objective Response Rate (ORR) as assessed by investigator based on RECIST 1.1","The percentage of subjects who had a best response of CR or PR",{"measure":89,"description":90,"timeFrame":20},"Phase 2 Cohort b Only: Percentage of ORR as assessed by IRC and as assessed by investigator based on RECIST 1.1 for HER2-expressing subjects and in subjects with prior ICI treatment","The percentage of subjects who had a best response of CR or PR, for Cohort 2b only",{"measure":92,"description":93,"timeFrame":20},"To evaluate the safety of DB-1303 with\u002Fwithout ritonavir or itraconazole","Percentage of Participants with Serious Adverse Events (SAEs), Treatment Emergent Adverse Events (TEAE), TEAEs \\>\u002F= G3, or TEAEs leading to dose reduction, interruption or discontinuation, Adverse Events of Special Interest, (AESIs), abnormal vital signs, abnormal 12-lead ECGs, abnormal safety laboratory tests, abnormal ECOG PS, abnormal ECHO\u002FMUGA (LVEF).",null,{"allocation":96,"interventionModel":97,"interventionModelDescription":94,"primaryPurpose":98,"observationalModel":94,"timePerspective":94,"maskingInfo":99},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":100,"maskingDescription":94,"whoMasked":94},"NONE","This is a multicenter, non-randomized (Except for Dose Expansion 1 and Dose Expansion 9 cohorts), open-label, multiple-dose, FIH study. The study consists of two parts: Part 1 adopts an accelerated titration at first dose level followed with classic \"3+3\" design to identify the MTD\u002FRP2D; Part 2 is a dose expansion phase to confirm the safety, tolerability and explore efficacy in selected malignant solid tumors at the MTD\u002Fthe RP2D. This study will enroll subjects with advanced\u002Funresectable, recurrent, or metastatic HER2-expressing malignant solid tumors.",[103,109,113,117,121,125,129,133,136,139,142,146,150,153,156,159,163,169,172,177,180,184,188,191],{"label":104,"type":105,"description":106,"interventionNames":107},"DB-1303\u002FBNT323 Dose Level 1","EXPERIMENTAL","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 1 on Day 1 of each cycle Q3W",[108],"Biological: DB-1303\u002FBNT323",{"label":110,"type":105,"description":111,"interventionNames":112},"DB-1303\u002FBNT323 Dose Level 2","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 2 on Day 1 of each cycle Q3W",[108],{"label":114,"type":105,"description":115,"interventionNames":116},"DB-1303\u002FBNT323 Dose Level 3","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 3 on Day 1 of each cycle Q3W",[108],{"label":118,"type":105,"description":119,"interventionNames":120},"DB-1303\u002FBNT323 Dose Level 4","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 4 on Day 1 of each cycle Q3W",[108],{"label":122,"type":105,"description":123,"interventionNames":124},"DB-1303\u002FBNT323 Dose Level 5","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 5 on Day 1 of each cycle Q3W",[108],{"label":126,"type":105,"description":127,"interventionNames":128},"DB-1303\u002FBNT323 Dose Expansion 1","Enrolled Subjects will be randomized to receive a single-dose of DB-1303\u002FBNT323 on a selected dose level 1 or dose level 2 Day 1 of each cycle Q3W",[108],{"label":130,"type":105,"description":131,"interventionNames":132},"DB-1303\u002FBNT323 Dose Expansion 2","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 on a selected dose level (RP2D) Day 1 of each cycle Q3W",[108],{"label":134,"type":105,"description":131,"interventionNames":135},"DB-1303\u002FBNT323 Dose Expansion 3",[108],{"label":137,"type":105,"description":131,"interventionNames":138},"DB-1303\u002FBNT323 Dose Expansion 4",[108],{"label":140,"type":105,"description":131,"interventionNames":141},"DB-1303\u002FBNT323 Dose Expansion 5",[108],{"label":143,"type":105,"description":144,"interventionNames":145},"DB-1303\u002FBNT323 Dose Level 6","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 6 on Day 1 of each cycle Q3W",[108],{"label":147,"type":105,"description":148,"interventionNames":149},"DB-1303\u002FBNT323 Dose Level 7","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 at Dose Level 7 on Day 1 of each cycle Q3W",[108],{"label":151,"type":105,"description":131,"interventionNames":152},"DB-1303\u002FBNT323 Dose Expansion 6",[108],{"label":154,"type":105,"description":131,"interventionNames":155},"DB-1303\u002FBNT323 Dose Expansion 7",[108],{"label":157,"type":105,"description":131,"interventionNames":158},"DB-1303\u002FBNT323 Dose Expansion 8",[108],{"label":160,"type":105,"description":161,"interventionNames":162},"DB-1303\u002FBNT323 Dose Expansion 9","Enrolled Subjects will be randomized to receive a single-dose of DB-1303\u002FBNT323 on a selected dose level 1 or dose level 2 on Day 1 of each cycle Q3W",[108],{"label":164,"type":105,"description":165,"interventionNames":166},"DB-1303\u002FBNT323 Dose Expansion 10","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 on a selected dose level (RP2D) Day 1 of each cycle Q3W along with ritonavir or itraconazole to assess the DDI potential",[108,167,168],"Drug: Ritonavir","Drug: Itraconazole",{"label":170,"type":105,"description":131,"interventionNames":171},"DB-1303\u002FBNT323 Dose Expansion 11",[108],{"label":173,"type":105,"description":174,"interventionNames":175},"DB-1303\u002FBNT323 Dose Expansion 12","Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 on a selected dose level 1 or dose level 2 in combination with Pertuzumab on Day 1 of each cycle Q3W",[108,176],"Drug: Pertuzumab Injection",{"label":178,"type":105,"description":131,"interventionNames":179},"DB-1303\u002FBNT323 Dose Expansion 13",[108],{"label":181,"type":105,"description":182,"interventionNames":183},"DB-1303\u002FBNT323 Dose Expansion 14","China Only:Subjects who were previously treated with trastuzumab and taxane will receive a single-dose of DB-1303\u002FBNT323 on a selected dose level (RP2D) Day 1 of each cycle Q3W",[108],{"label":185,"type":105,"description":186,"interventionNames":187},"DB-1303\u002FBNT323 Dose Expansion 15","China Only: Enrolled Subjects will receive a single-dose of DB-1303\u002FBNT323 on a selected dose level (RP2D) Day 1 of each cycle Q3W",[108],{"label":189,"type":105,"description":131,"interventionNames":190},"DB-1303\u002FBNT323 Dose Expansion 16",[108],{"label":192,"type":105,"description":131,"interventionNames":193},"DB-1303\u002FBNT323 Dose Expansion 17",[108],[195,200,204,208],{"type":196,"name":197,"description":198,"armGroupLabels":199,"otherNames":94},"BIOLOGICAL","DB-1303\u002FBNT323","Administered IV",[126,164,170,173,178,181,185,189,192,130,134,137,140,151,154,157,160,104,110,114,118,122,143,147],{"type":201,"name":202,"description":198,"armGroupLabels":203,"otherNames":94},"DRUG","Pertuzumab Injection",[173],{"type":201,"name":205,"description":206,"armGroupLabels":207,"otherNames":94},"Ritonavir","Administered oral",[164],{"type":201,"name":209,"description":206,"armGroupLabels":210,"otherNames":94},"Itraconazole",[164],[212],{"name":213,"role":214,"phone":215,"phoneExt":94,"email":216},"Britney Winterberger","CONTACT","+1-513-403-8568","britney.winterberger@tigermedgrp.com",[218,232,241,250,260,270,279,288,298,307,315,325,335,345,355,365,375,381,391,401,411,421,429,435,444,454,464,474,484,489,498,508,518,527,537,547,559,568,578,588,600,608,613,622,627,636,645,650,659,668,677,682,687,696,704,713,722,731,736,745,754,759,764,773,781,789,794,803,808,816,825,830,839,848,853,858,866,874,882,891,900,905,910,919,928,937,942,947,952,960,971,982,992,999,1006,1013,1025,1035,1042,1049,1056,1063],{"facility":219,"status":220,"city":221,"state":222,"zip":223,"country":224,"countryCode":225,"cosmosGeoPoint":226,"geoPoint":231,"contacts":94},"Helios Clinical Research","ACTIVE_NOT_RECRUITING","Cerritos","California","90703","United States","US",{"type":227,"coordinates":228},"Point",[229,230],-118.06479,33.85835,{"lat":230,"lon":229},{"facility":233,"status":220,"city":234,"state":222,"zip":235,"country":224,"countryCode":225,"cosmosGeoPoint":236,"geoPoint":240,"contacts":94},"California Research Institute","Los Angeles","90027",{"type":227,"coordinates":237},[238,239],-118.24368,34.05223,{"lat":239,"lon":238},{"facility":242,"status":220,"city":243,"state":222,"zip":244,"country":224,"countryCode":225,"cosmosGeoPoint":245,"geoPoint":249,"contacts":94},"Sharp Memorial Hospital","San Diego","92123",{"type":227,"coordinates":246},[247,248],-117.16472,32.71571,{"lat":248,"lon":247},{"facility":251,"status":220,"city":252,"state":253,"zip":254,"country":224,"countryCode":225,"cosmosGeoPoint":255,"geoPoint":259,"contacts":94},"Washington Cancer Institute at MedStar Washington Hospital Center","Washington D.C.","District of Columbia","20010",{"type":227,"coordinates":256},[257,258],-77.03637,38.89511,{"lat":258,"lon":257},{"facility":261,"status":220,"city":262,"state":263,"zip":264,"country":224,"countryCode":225,"cosmosGeoPoint":265,"geoPoint":269,"contacts":94},"Advanced Research LLC","Coral Springs","Florida","33065",{"type":227,"coordinates":266},[267,268],-80.2706,26.27119,{"lat":268,"lon":267},{"facility":271,"status":220,"city":272,"state":263,"zip":273,"country":224,"countryCode":225,"cosmosGeoPoint":274,"geoPoint":278,"contacts":94},"The Oncology Institute of Hope and Innovation","Lakeland","33812",{"type":227,"coordinates":275},[276,277],-81.9498,28.03947,{"lat":277,"lon":276},{"facility":280,"status":220,"city":281,"state":263,"zip":282,"country":224,"countryCode":225,"cosmosGeoPoint":283,"geoPoint":287,"contacts":94},"D&H Cancer Research Center LLC","Margate","33063",{"type":227,"coordinates":284},[285,286],-80.20644,26.24453,{"lat":286,"lon":285},{"facility":289,"status":290,"city":291,"state":263,"zip":292,"country":224,"countryCode":225,"cosmosGeoPoint":293,"geoPoint":297,"contacts":94},"HCA Mercy Hospital","WITHDRAWN","Miami","33133",{"type":227,"coordinates":294},[295,296],-80.19366,25.77427,{"lat":296,"lon":295},{"facility":299,"status":220,"city":300,"state":263,"zip":301,"country":224,"countryCode":225,"cosmosGeoPoint":302,"geoPoint":306,"contacts":94},"BRCR Medical Center Inc.","Plantation","33322",{"type":227,"coordinates":303},[304,305],-80.23184,26.13421,{"lat":305,"lon":304},{"facility":299,"status":220,"city":308,"state":263,"zip":309,"country":224,"countryCode":225,"cosmosGeoPoint":310,"geoPoint":314,"contacts":94},"Tamarac","33321",{"type":227,"coordinates":311},[312,313],-80.24977,26.21286,{"lat":313,"lon":312},{"facility":316,"status":220,"city":317,"state":318,"zip":319,"country":224,"countryCode":225,"cosmosGeoPoint":320,"geoPoint":324,"contacts":94},"Southeastern Regional Medical Center, LLC","Newnan","Georgia","30265",{"type":227,"coordinates":321},[322,323],-84.79966,33.38067,{"lat":323,"lon":322},{"facility":326,"status":220,"city":327,"state":328,"zip":329,"country":224,"countryCode":225,"cosmosGeoPoint":330,"geoPoint":334,"contacts":94},"Kapi'olani Medical Center for Women and Children","Honolulu","Hawaii","96826",{"type":227,"coordinates":331},[332,333],-157.85833,21.30694,{"lat":333,"lon":332},{"facility":336,"status":220,"city":337,"state":338,"zip":339,"country":224,"countryCode":225,"cosmosGeoPoint":340,"geoPoint":344,"contacts":94},"University of Chicago","Chicago","Illinois","60637",{"type":227,"coordinates":341},[342,343],-87.65005,41.85003,{"lat":343,"lon":342},{"facility":346,"status":290,"city":347,"state":348,"zip":349,"country":224,"countryCode":225,"cosmosGeoPoint":350,"geoPoint":354,"contacts":94},"Women's Cancer Care","Covington","Louisiana","70433",{"type":227,"coordinates":351},[352,353],-90.10042,30.47549,{"lat":353,"lon":352},{"facility":356,"status":290,"city":357,"state":358,"zip":359,"country":224,"countryCode":225,"cosmosGeoPoint":360,"geoPoint":364,"contacts":94},"Holy Cross Hospital","Silver Spring","Maryland","20910",{"type":227,"coordinates":361},[362,363],-77.02609,38.99067,{"lat":363,"lon":362},{"facility":366,"status":220,"city":367,"state":368,"zip":369,"country":224,"countryCode":225,"cosmosGeoPoint":370,"geoPoint":374,"contacts":94},"Massachusetts General Hospital","Boston","Massachusetts","02214",{"type":227,"coordinates":371},[372,373],-71.05977,42.35843,{"lat":373,"lon":372},{"facility":376,"status":220,"city":367,"state":368,"zip":377,"country":224,"countryCode":225,"cosmosGeoPoint":378,"geoPoint":380,"contacts":94},"Beth Israel Deaconess Medical Center","02215",{"type":227,"coordinates":379},[372,373],{"lat":373,"lon":372},{"facility":382,"status":290,"city":383,"state":384,"zip":385,"country":224,"countryCode":225,"cosmosGeoPoint":386,"geoPoint":390,"contacts":94},"Profound Research LLC\u002FMichigan Hematology & Oncology Consultants","Dearborn","Michigan","48126",{"type":227,"coordinates":387},[388,389],-83.17631,42.32226,{"lat":389,"lon":388},{"facility":392,"status":220,"city":393,"state":394,"zip":395,"country":224,"countryCode":225,"cosmosGeoPoint":396,"geoPoint":400,"contacts":94},"David C. Pratt Cancer Center","St Louis","Missouri","63141",{"type":227,"coordinates":397},[398,399],-90.19789,38.62727,{"lat":399,"lon":398},{"facility":402,"status":290,"city":403,"state":404,"zip":405,"country":224,"countryCode":225,"cosmosGeoPoint":406,"geoPoint":410,"contacts":94},"Women's Cancer Center of Nevada","Las Vegas","Nevada","89106",{"type":227,"coordinates":407},[408,409],-115.13722,36.17497,{"lat":409,"lon":408},{"facility":412,"status":290,"city":413,"state":414,"zip":415,"country":224,"countryCode":225,"cosmosGeoPoint":416,"geoPoint":420,"contacts":94},"Northwell Health","Lake Success","New York","11042",{"type":227,"coordinates":417},[418,419],-73.71763,40.77066,{"lat":419,"lon":418},{"facility":422,"status":220,"city":414,"state":414,"zip":423,"country":224,"countryCode":225,"cosmosGeoPoint":424,"geoPoint":428,"contacts":94},"Laura & Isaac Perlmutter Cancer Center at NYC Langone Health","10016",{"type":227,"coordinates":425},[426,427],-74.00597,40.71427,{"lat":427,"lon":426},{"facility":430,"status":220,"city":414,"state":414,"zip":431,"country":224,"countryCode":225,"cosmosGeoPoint":432,"geoPoint":434,"contacts":94},"Memorial Sloan Kettering Cancer Center","10065",{"type":227,"coordinates":433},[426,427],{"lat":427,"lon":426},{"facility":436,"status":220,"city":437,"state":414,"zip":438,"country":224,"countryCode":225,"cosmosGeoPoint":439,"geoPoint":443,"contacts":94},"North Shore Hematology Oncology Associate P.C. DBA New York Cancer and Blood Specialists","Shirley","11967",{"type":227,"coordinates":440},[441,442],-72.8676,40.80149,{"lat":442,"lon":441},{"facility":445,"status":290,"city":446,"state":447,"zip":448,"country":224,"countryCode":225,"cosmosGeoPoint":449,"geoPoint":453,"contacts":94},"Regional Medical Oncology Center","Wilson","North Carolina","27893",{"type":227,"coordinates":450},[451,452],-77.91554,35.72127,{"lat":452,"lon":451},{"facility":455,"status":220,"city":456,"state":457,"zip":458,"country":224,"countryCode":225,"cosmosGeoPoint":459,"geoPoint":463,"contacts":94},"Gabrail Cancer Center","Canton","Ohio","44718",{"type":227,"coordinates":460},[461,462],-81.37845,40.79895,{"lat":462,"lon":461},{"facility":465,"status":220,"city":466,"state":467,"zip":468,"country":224,"countryCode":225,"cosmosGeoPoint":469,"geoPoint":473,"contacts":94},"University of Oklahoma","Oklahoma City","Oklahoma","73104",{"type":227,"coordinates":470},[471,472],-97.51643,35.46756,{"lat":472,"lon":471},{"facility":475,"status":290,"city":476,"state":477,"zip":478,"country":224,"countryCode":225,"cosmosGeoPoint":479,"geoPoint":483,"contacts":94},"Rittenhouse Hematology Oncology","Philadelphia","Pennsylvania","19107",{"type":227,"coordinates":480},[481,482],-75.16362,39.95238,{"lat":482,"lon":481},{"facility":485,"status":220,"city":476,"state":477,"zip":478,"country":224,"countryCode":225,"cosmosGeoPoint":486,"geoPoint":488,"contacts":94},"Thomas Jefferson University",{"type":227,"coordinates":487},[481,482],{"lat":482,"lon":481},{"facility":490,"status":220,"city":491,"state":477,"zip":492,"country":224,"countryCode":225,"cosmosGeoPoint":493,"geoPoint":497,"contacts":94},"AHN West Penn Hospital","Pittsburgh","15224",{"type":227,"coordinates":494},[495,496],-79.99589,40.44062,{"lat":496,"lon":495},{"facility":499,"status":220,"city":500,"state":501,"zip":502,"country":224,"countryCode":225,"cosmosGeoPoint":503,"geoPoint":507,"contacts":94},"Tennessee Oncology","Nashville","Tennessee","37203",{"type":227,"coordinates":504},[505,506],-86.78444,36.16589,{"lat":506,"lon":505},{"facility":509,"status":290,"city":510,"state":511,"zip":512,"country":224,"countryCode":225,"cosmosGeoPoint":513,"geoPoint":517,"contacts":94},"Clinical Trial Network","Houston","Texas","77074",{"type":227,"coordinates":514},[515,516],-95.36327,29.76328,{"lat":516,"lon":515},{"facility":519,"status":220,"city":520,"state":511,"zip":521,"country":224,"countryCode":225,"cosmosGeoPoint":522,"geoPoint":526,"contacts":94},"Oncology and Hematology of South Texas, PA","Laredo","78041",{"type":227,"coordinates":523},[524,525],-99.50754,27.50641,{"lat":525,"lon":524},{"facility":528,"status":220,"city":529,"state":530,"zip":531,"country":224,"countryCode":225,"cosmosGeoPoint":532,"geoPoint":536,"contacts":94},"NEXT Virginia","Fairfax","Virginia","22031",{"type":227,"coordinates":533},[534,535],-77.30637,38.84622,{"lat":535,"lon":534},{"facility":538,"status":220,"city":539,"state":540,"zip":541,"country":224,"countryCode":225,"cosmosGeoPoint":542,"geoPoint":546,"contacts":94},"Swedish Cancer Institute","Seattle","Washington","98104",{"type":227,"coordinates":543},[544,545],-122.33207,47.60621,{"lat":545,"lon":544},{"facility":548,"status":220,"city":549,"state":550,"zip":551,"country":552,"countryCode":553,"cosmosGeoPoint":554,"geoPoint":558,"contacts":94},"Scientia Clinical Research LTD","Randwick","New South Wales","2031","Australia","AU",{"type":227,"coordinates":555},[556,557],151.24895,-33.91439,{"lat":557,"lon":556},{"facility":560,"status":220,"city":561,"state":550,"zip":562,"country":552,"countryCode":553,"cosmosGeoPoint":563,"geoPoint":567,"contacts":94},"Macquarie Clinical Trials Unit","Sydney","2109",{"type":227,"coordinates":564},[565,566],151.20732,-33.86785,{"lat":566,"lon":565},{"facility":569,"status":220,"city":570,"state":571,"zip":572,"country":552,"countryCode":553,"cosmosGeoPoint":573,"geoPoint":577,"contacts":94},"Integrated Clinical Oncology Network Pty Ltd (Icon)","South Brisbane","Queensland","4101",{"type":227,"coordinates":574},[575,576],153.02049,-27.48034,{"lat":576,"lon":575},{"facility":579,"status":220,"city":580,"state":581,"zip":582,"country":552,"countryCode":553,"cosmosGeoPoint":583,"geoPoint":587,"contacts":94},"Monash Health","Melbourne","Victoria","3168",{"type":227,"coordinates":584},[585,586],144.96332,-37.814,{"lat":586,"lon":585},{"facility":589,"status":590,"city":591,"state":592,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":595,"geoPoint":599,"contacts":94},"The first affiliated hospital of Bengbu medical college","RECRUITING","Bengbu","Anhui","China","CN",{"type":227,"coordinates":596},[597,598],117.36083,32.94083,{"lat":598,"lon":597},{"facility":601,"status":590,"city":602,"state":592,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":603,"geoPoint":607,"contacts":94},"Anhui provincial hospital","Hefei",{"type":227,"coordinates":604},[605,606],117.28083,31.86389,{"lat":606,"lon":605},{"facility":609,"status":590,"city":602,"state":592,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":610,"geoPoint":612,"contacts":94},"The Second Hospital of Anhui Medical University",{"type":227,"coordinates":611},[605,606],{"lat":606,"lon":605},{"facility":614,"status":590,"city":615,"state":616,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":617,"geoPoint":621,"contacts":94},"Beijing Cancer Hospital","Beijing","Beijing Municipality",{"type":227,"coordinates":618},[619,620],116.39723,39.9075,{"lat":620,"lon":619},{"facility":623,"status":590,"city":615,"state":616,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":624,"geoPoint":626,"contacts":94},"Cancer Hospital Chinese Academy of Medical Science",{"type":227,"coordinates":625},[619,620],{"lat":620,"lon":619},{"facility":628,"status":590,"city":629,"state":630,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":631,"geoPoint":635,"contacts":94},"The First Hospital of Jilin University","Hongcun","Changchun",{"type":227,"coordinates":632},[633,634],117.98167,30.00361,{"lat":634,"lon":633},{"facility":637,"status":590,"city":638,"state":639,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":640,"geoPoint":644,"contacts":94},"Chongqing University Cancer Hospital","Chongqing","Chongqing Municipality",{"type":227,"coordinates":641},[642,643],106.55771,29.56026,{"lat":643,"lon":642},{"facility":646,"status":590,"city":638,"state":639,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":647,"geoPoint":649,"contacts":94},"The First affiliated Hospital of Chongqing Medical University",{"type":227,"coordinates":648},[642,643],{"lat":643,"lon":642},{"facility":651,"status":590,"city":652,"state":653,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":654,"geoPoint":658,"contacts":94},"The First affiliated hospital of Xiamen University","Xiamen","Fujian",{"type":227,"coordinates":655},[656,657],118.08187,24.47979,{"lat":657,"lon":656},{"facility":660,"status":590,"city":661,"state":662,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":663,"geoPoint":667,"contacts":94},"Gansu Provincial Maternity and Child-care Hospital","Lanzhou","Gansu",{"type":227,"coordinates":664},[665,666],103.83987,36.05701,{"lat":666,"lon":665},{"facility":669,"status":590,"city":670,"state":671,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":672,"geoPoint":676,"contacts":94},"Huizhou First Hospital","Guangzhou","Guangdong",{"type":227,"coordinates":673},[674,675],113.25,23.11667,{"lat":675,"lon":674},{"facility":678,"status":590,"city":670,"state":671,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":679,"geoPoint":681,"contacts":94},"Sun Yat-Sen Memorial Hospital of Zhongshan University",{"type":227,"coordinates":680},[674,675],{"lat":675,"lon":674},{"facility":683,"status":590,"city":670,"state":671,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":684,"geoPoint":686,"contacts":94},"The First affiliated hospital, Sun Yat-sen University",{"type":227,"coordinates":685},[674,675],{"lat":675,"lon":674},{"facility":688,"status":590,"city":689,"state":690,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":691,"geoPoint":695,"contacts":94},"Cancer Hospital of Guangxi Medical University","Nanning","Guangxi",{"type":227,"coordinates":692},[693,694],108.31667,22.81667,{"lat":694,"lon":693},{"facility":697,"status":590,"city":698,"state":690,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":699,"geoPoint":703,"contacts":94},"The First people's hospital of Yulin","Yulin",{"type":227,"coordinates":700},[701,702],110.14686,22.6305,{"lat":702,"lon":701},{"facility":705,"status":590,"city":706,"state":707,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":708,"geoPoint":712,"contacts":94},"Affiliated Hospital of Hebei University","Baoding","Hebei",{"type":227,"coordinates":709},[710,711],115.46246,38.87288,{"lat":711,"lon":710},{"facility":714,"status":590,"city":715,"state":716,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":717,"geoPoint":721,"contacts":94},"Henan cancer Hospital","Zhengzhou","Hehan",{"type":227,"coordinates":718},[719,720],113.64861,34.75778,{"lat":720,"lon":719},{"facility":723,"status":590,"city":724,"state":725,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":726,"geoPoint":730,"contacts":94},"Anyang Tumor Hospital","Anyang","Henan",{"type":227,"coordinates":727},[728,729],114.38278,36.096,{"lat":729,"lon":728},{"facility":732,"status":590,"city":715,"state":725,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":733,"geoPoint":735,"contacts":94},"The First Affiliated Hospital of Zhengzhou University",{"type":227,"coordinates":734},[719,720],{"lat":720,"lon":719},{"facility":737,"status":590,"city":738,"state":739,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":740,"geoPoint":744,"contacts":94},"Union hospital Tongji Medical college Huazhong university of science and technology","Wuhan","Hubei",{"type":227,"coordinates":741},[742,743],114.26667,30.58333,{"lat":743,"lon":742},{"facility":746,"status":590,"city":747,"state":748,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":749,"geoPoint":753,"contacts":94},"Hunan Cancer Hospital","Changsha","Hunan",{"type":227,"coordinates":750},[751,752],112.97087,28.19874,{"lat":752,"lon":751},{"facility":755,"status":590,"city":747,"state":748,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":756,"geoPoint":758,"contacts":94},"Hunan People's Provincial Hospital",{"type":227,"coordinates":757},[751,752],{"lat":752,"lon":751},{"facility":760,"status":590,"city":747,"state":748,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":761,"geoPoint":763,"contacts":94},"Xiangya Hospital Central South University",{"type":227,"coordinates":762},[751,752],{"lat":752,"lon":751},{"facility":765,"status":290,"city":766,"state":767,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":768,"geoPoint":772,"contacts":94},"Changzhou Tumor Hospital","Changzhou","Jiangsu",{"type":227,"coordinates":769},[770,771],119.95401,31.77359,{"lat":771,"lon":770},{"facility":774,"status":590,"city":775,"state":767,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":776,"geoPoint":780,"contacts":94},"Affiliated Hospital of Jiangnan University","Wuxi",{"type":227,"coordinates":777},[778,779],120.28857,31.56887,{"lat":779,"lon":778},{"facility":782,"status":590,"city":783,"state":767,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":784,"geoPoint":788,"contacts":94},"The Affiliated Hospital of Xuzhou Medical College","Xuzhou",{"type":227,"coordinates":785},[786,787],117.28386,34.20442,{"lat":787,"lon":786},{"facility":790,"status":290,"city":783,"state":767,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":791,"geoPoint":793,"contacts":94},"Xuzhou Cancer Hospital",{"type":227,"coordinates":792},[786,787],{"lat":787,"lon":786},{"facility":795,"status":590,"city":796,"state":797,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":798,"geoPoint":802,"contacts":94},"Jiangxi maternal and child health hospital","Nanchang","Jiangxi",{"type":227,"coordinates":799},[800,801],115.85306,28.68396,{"lat":801,"lon":800},{"facility":804,"status":590,"city":796,"state":797,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":805,"geoPoint":807,"contacts":94},"The Third Hospital of Nanchang",{"type":227,"coordinates":806},[800,801],{"lat":801,"lon":800},{"facility":809,"status":590,"city":630,"state":810,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":811,"geoPoint":815,"contacts":94},"Jilin Cancer Hospital","Jilin",{"type":227,"coordinates":812},[813,814],125.32278,43.88,{"lat":814,"lon":813},{"facility":817,"status":590,"city":818,"state":819,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":820,"geoPoint":824,"contacts":94},"Liaoning cancer hospital & Institute","Shenyang","Liaoning",{"type":227,"coordinates":821},[822,823],123.43278,41.79222,{"lat":823,"lon":822},{"facility":826,"status":590,"city":818,"state":819,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":827,"geoPoint":829,"contacts":94},"The First Hospital of China Medical University",{"type":227,"coordinates":828},[822,823],{"lat":823,"lon":822},{"facility":831,"status":590,"city":832,"state":833,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":834,"geoPoint":838,"contacts":94},"The First Affiliated Hospital Of Xi'an Jiaotong University","Xi'an","Shaanxi",{"type":227,"coordinates":835},[836,837],108.92861,34.25833,{"lat":837,"lon":836},{"facility":840,"status":590,"city":841,"state":842,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":843,"geoPoint":847,"contacts":94},"Central hospital affiliated to Shandong first medical university","Jinan","Shandong",{"type":227,"coordinates":844},[845,846],116.99722,36.66833,{"lat":846,"lon":845},{"facility":849,"status":590,"city":841,"state":842,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":850,"geoPoint":852,"contacts":94},"Jinan Central Hospital",{"type":227,"coordinates":851},[845,846],{"lat":846,"lon":845},{"facility":854,"status":590,"city":841,"state":842,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":855,"geoPoint":857,"contacts":94},"Shandong Cancer hospital & institute",{"type":227,"coordinates":856},[845,846],{"lat":846,"lon":845},{"facility":859,"status":590,"city":860,"state":842,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":861,"geoPoint":865,"contacts":94},"Affiliated hospital of Jining medical university","Jining",{"type":227,"coordinates":862},[863,864],116.58139,35.405,{"lat":864,"lon":863},{"facility":867,"status":590,"city":868,"state":842,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":869,"geoPoint":873,"contacts":94},"Linyi Tumor Hospital","Liaocheng",{"type":227,"coordinates":870},[871,872],116.00247,36.45064,{"lat":872,"lon":871},{"facility":875,"status":590,"city":876,"state":842,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":877,"geoPoint":881,"contacts":94},"Zibo Central hospital","Zibo",{"type":227,"coordinates":878},[879,880],118.06333,36.79056,{"lat":880,"lon":879},{"facility":883,"status":290,"city":884,"state":885,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":886,"geoPoint":890,"contacts":94},"Yantai Yuhuangding Hospital","Yantai","Shangdong",{"type":227,"coordinates":887},[888,889],121.44081,37.47649,{"lat":889,"lon":888},{"facility":892,"status":590,"city":893,"state":894,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":895,"geoPoint":899,"contacts":94},"Fudan University","Shanghai","Shanghai Municipality",{"type":227,"coordinates":896},[897,898],121.45806,31.22222,{"lat":898,"lon":897},{"facility":901,"status":590,"city":893,"state":894,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":902,"geoPoint":904,"contacts":94},"Shanghai Tenth people's Hospital",{"type":227,"coordinates":903},[897,898],{"lat":898,"lon":897},{"facility":906,"status":590,"city":893,"state":894,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":907,"geoPoint":909,"contacts":94},"The Obstetrics & Gynecology Hospital Affiliated to Fudan University",{"type":227,"coordinates":908},[897,898],{"lat":898,"lon":897},{"facility":911,"status":590,"city":912,"state":913,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":914,"geoPoint":918,"contacts":94},"Tianjin Medical university cancer institute & hospital","Tianjin","Tianjin Municipality",{"type":227,"coordinates":915},[916,917],117.17667,39.14222,{"lat":917,"lon":916},{"facility":920,"status":590,"city":921,"state":922,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":923,"geoPoint":927,"contacts":94},"Yunnan Provincial Cancer Hospital","Kunming","Yunnan",{"type":227,"coordinates":924},[925,926],102.71833,25.03889,{"lat":926,"lon":925},{"facility":929,"status":590,"city":930,"state":931,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":932,"geoPoint":936,"contacts":94},"1st affliated hospital of Zhejiang University","Hangzhou","Zhejiang",{"type":227,"coordinates":933},[934,935],120.16142,30.29365,{"lat":935,"lon":934},{"facility":938,"status":590,"city":930,"state":931,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":939,"geoPoint":941,"contacts":94},"The second affiliated hospital of Zhejiang University School of Medicine",{"type":227,"coordinates":940},[934,935],{"lat":935,"lon":934},{"facility":943,"status":590,"city":930,"state":931,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":944,"geoPoint":946,"contacts":94},"Women's hospital school of medicine Zhejiang University",{"type":227,"coordinates":945},[934,935],{"lat":935,"lon":934},{"facility":948,"status":590,"city":930,"state":931,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":949,"geoPoint":951,"contacts":94},"Zhejiang Cancer Hospital",{"type":227,"coordinates":950},[934,935],{"lat":935,"lon":934},{"facility":953,"status":290,"city":954,"state":931,"zip":94,"country":593,"countryCode":594,"cosmosGeoPoint":955,"geoPoint":959,"contacts":94},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou",{"type":227,"coordinates":956},[957,958],120.66682,27.99942,{"lat":958,"lon":957},{"facility":961,"status":290,"city":962,"state":94,"zip":963,"country":964,"countryCode":965,"cosmosGeoPoint":966,"geoPoint":970,"contacts":94},"BRCR Global Puerto Rico LLC.","Mayagüez","00682","Puerto Rico","PR",{"type":227,"coordinates":967},[968,969],-67.13962,18.20107,{"lat":969,"lon":968},{"facility":972,"status":220,"city":973,"state":974,"zip":975,"country":976,"countryCode":94,"cosmosGeoPoint":977,"geoPoint":981,"contacts":94},"Seoul National University Bundang Hospital","Gyeonggi-do","Bundang-gu","13620","South Korea",{"type":227,"coordinates":978},[979,980],126.76917,37.58944,{"lat":980,"lon":979},{"facility":983,"status":220,"city":984,"state":985,"zip":986,"country":976,"countryCode":94,"cosmosGeoPoint":987,"geoPoint":991,"contacts":94},"Samsung Medical Center","Seoul","Gangnam-gu","06351",{"type":227,"coordinates":988},[989,990],126.9784,37.566,{"lat":990,"lon":989},{"facility":993,"status":220,"city":973,"state":994,"zip":995,"country":976,"countryCode":94,"cosmosGeoPoint":996,"geoPoint":998,"contacts":94},"National Cancer Center","Ilsandong-gu","10408",{"type":227,"coordinates":997},[979,980],{"lat":980,"lon":979},{"facility":1000,"status":220,"city":984,"state":1001,"zip":1002,"country":976,"countryCode":94,"cosmosGeoPoint":1003,"geoPoint":1005,"contacts":94},"Severance Hospital","Seodaemun-gu","03722",{"type":227,"coordinates":1004},[989,990],{"lat":990,"lon":989},{"facility":1007,"status":220,"city":984,"state":1008,"zip":1009,"country":976,"countryCode":94,"cosmosGeoPoint":1010,"geoPoint":1012,"contacts":94},"Asan Medical Center","Songpa-gu","05505",{"type":227,"coordinates":1011},[989,990],{"lat":990,"lon":989},{"facility":1014,"status":220,"city":1015,"state":1016,"zip":1017,"country":1018,"countryCode":1019,"cosmosGeoPoint":1020,"geoPoint":1024,"contacts":94},"Taipei Veterans General Hospital","Taipei","Beitou District","11217","Taiwan","TW",{"type":227,"coordinates":1021},[1022,1023],121.52639,25.05306,{"lat":1023,"lon":1022},{"facility":1026,"status":220,"city":1027,"state":1028,"zip":1029,"country":1018,"countryCode":1019,"cosmosGeoPoint":1030,"geoPoint":1034,"contacts":94},"Changhua Christian Hospital","Changhua","Changhua County","50006",{"type":227,"coordinates":1031},[1032,1033],120.5512,24.0692,{"lat":1033,"lon":1032},{"facility":1036,"status":220,"city":1015,"state":1037,"zip":1038,"country":1018,"countryCode":1019,"cosmosGeoPoint":1039,"geoPoint":1041,"contacts":94},"Taipei Medical University Hospital","Xinyi District","110301",{"type":227,"coordinates":1040},[1022,1023],{"lat":1023,"lon":1022},{"facility":1043,"status":220,"city":1015,"state":1044,"zip":1045,"country":1018,"countryCode":1019,"cosmosGeoPoint":1046,"geoPoint":1048,"contacts":94},"Taipei Medical University-Shuang Ho Hospital","Zhonghe District","235041",{"type":227,"coordinates":1047},[1022,1023],{"lat":1023,"lon":1022},{"facility":1050,"status":220,"city":1015,"state":1051,"zip":1052,"country":1018,"countryCode":1019,"cosmosGeoPoint":1053,"geoPoint":1055,"contacts":94},"Mackay Memorial Hospital-Taipei","Zhongshan District","10449",{"type":227,"coordinates":1054},[1022,1023],{"lat":1023,"lon":1022},{"facility":1057,"status":220,"city":1015,"state":1058,"zip":1059,"country":1018,"countryCode":1019,"cosmosGeoPoint":1060,"geoPoint":1062,"contacts":94},"National Taiwan University Hospital","Zhongzheng District","100225",{"type":227,"coordinates":1061},[1022,1023],{"lat":1023,"lon":1022},{"facility":1064,"status":220,"city":1065,"state":1066,"zip":1067,"country":1018,"countryCode":1019,"cosmosGeoPoint":1068,"geoPoint":1072,"contacts":94},"Kaohsiung Veterans General Hospital","Kaohsiung City","Zuoying District","81362",{"type":227,"coordinates":1069},[1070,1071],120.31333,22.61626,{"lat":1071,"lon":1070},{"type":1074,"investigatorFullName":94,"investigatorTitle":94,"investigatorAffiliation":94,"oldNameTitle":94,"oldOrganization":94},"SPONSOR",[1076],{"name":1077,"class":6},"BioNTech SE","100450837",false,"NCT05150691","A Phase 1\u002F2a Study of DB-1303\u002FBNT323 in Advanced\u002FMetastatic Solid Tumors","A Phase 1\u002F2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1303\u002FBNT323 in Patients With Advanced\u002FMetastatic Solid Tumors","Inclusion Criteria:\n\n* Has a pathologically documented HER2-positive or HER2-expressing (except for cohort 2h where the requirement is HER2-null), advanced\u002Funresectable, recurrent, or metastatic malignant solid tumor that is refractory to or intolerable with standard treatment, or for which no standard treatment is available.\n* At least 1 measurable lesion (per RECIST 1.1)\n* Provide signed informed consent\n* ECOG performance status (PS) of 0-1.\n* LVEF ≥ 50% by ECHO or MUGA\n* Adequate organ functions\n* Provide pre-existing diagnosis of HER2 status or resected tumor samples or undergo fresh tumor biopsy for HER2 testing.\n* Life expectancy of ≥ 3 months.\n\nAdditional Inclusion Criteria for Part 2 Expansion Group 9:\n\n1\\. Has pathologically documented advanced\u002Funresectable, recurrent, or metastatic EC (including UCS and USPC) and has progressed on or after at least 1 line of systemic treatment including platinum-based therapy and exposure to ICI but no more than prior 3 lines of therapy for advanced\u002Funresectable, or metastatic disease. Note: endocrine therapy will not qualify as a systemic therapy line.\n\nExclusion Criteria:\n\n* History of symptomatic CHF (New York Heart Association \\[NYHA\\] classes II-IV) or serious cardiac arrhythmia requiring treatment.\n* History of myocardial infarction or unstable angina within 6 months before Day 1.\n* Average QTcF \\> 450 ms in males and \\> 470 ms in females\n* History of clinically significant lung diseases\n* Uncontrolled infection requiring IV antibiotics, antivirals, or antifungals.\n* HIV infection with AIDS defining illness or active viral hepatitis.\n* Clinically active brain metastases\n* Unresolved toxicities from previous anticancer therapy, defined as toxicities not yet resolved to NCI-CTCAE version 5.0, Grade ≤ 1 or baseline.\n* A known hypersensitivity to either the drug substances or inactive ingredients in the drug product.\n* Part 2 (expansion) Only:Multiple primary malignancies within 3 years, except adequately resected non- melanoma skin cancer, curatively treated in-situ disease, other solid tumors curatively treated, or contralateral breast cancer.","ALL","18 Years",{"count":1087,"type":1088},796,"ESTIMATED","INTERVENTIONAL",[1091,1092],"PHASE1","PHASE2","This is a dose-escalation and dose-expansion Phase 1\u002F2a trial to evaluate the safety and tolerability of DB-1303\u002FBNT323 in subjects with advanced solid tumors that express HER2.",[1095],"HER2-positive Advanced Solid Tumor",[1097,1098,1099,1100,1101,1102,1095,1103,1104,1105,1106,1107,1108,1109,1110,1111,1112,1113,1114,1115,1116,1117,1118,1119,1120,1121,1122,1123,1124,1125],"HER2","HER2-positive","HER2-positive Breast Cancer","HER2-positive Gastric Cancer","HER2-positive Endometrial Cancer","HER2-positive Biliary Tract Cancer","HER2 low","HER2 high","metastatic cancer","HER2-positive GEJ","Uterine serous papillary carcinoma","USPC","recurrent cancer","carcinoma","neoplasms","breast neoplasms","gastrointestinal neoplasms","endometrial neoplasms","biliary tract neoplasms","Antineoplastic Agents, Biological","stomach cancer","bile duct cancer","Cholangiocarcinoma","liver cancer","liver neoplasms","NSCLC","Non-Small Cell Lung Cancer","NSCLC HER2 mutation","HER2 Low Breast Cancer","2026-01-27",{"date":1128,"type":1129},"2026-01-28","ACTUAL",{"date":1131,"type":1129},"2022-01-31",{"date":1133,"type":1088},"2027-10",{"name":5,"class":6},102]