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Fe","Valencia","46026",{"type":69,"coordinates":469},[470,471],-0.37966,39.47391,{"lat":471,"lon":470},{"facility":474,"status":76,"city":475,"state":40,"zip":476,"country":477,"cosmosGeoPoint":478,"geoPoint":482,"contacts":40},"Edinburgh Cancer Centre","Edinburgh","EH4 2XU","United Kingdom",{"type":69,"coordinates":479},[480,481],-3.19648,55.95206,{"lat":481,"lon":480},{"facility":484,"status":76,"city":485,"state":40,"zip":486,"country":477,"cosmosGeoPoint":40,"geoPoint":40,"contacts":40},"The Christie Hospital","Greater Manchester","M20 4BX",{"type":488,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100054019",false,"NCT04771130","A Study of BGB-11417 in Participants With Myeloid Malignancies","A Phase 1b\u002F2, Open-Label, Dose Finding, and Expansion Study of the Bcl-2 Inhibitor BGB-11417 in Patients With Myeloid Malignancies","Key Inclusion Criteria:\n\n1. Confirmed diagnosis of one of the following by 2016 World Health Organization criteria:\n\n   * AML, nonacute promyelocytic leukemia\n   * MDS\n   * MDS\u002FMPN\n2. Eastern Cooperative Oncology Group performance status of 0 to 2.\n3. Adequate organ function defined as:\n\n   * Creatinine clearance ≥ 50 milliliters\u002Fminute (mL\u002Fmin) (or between 30 and 49 mL\u002Fmin in unfit AML cohort)\n   * Adequate liver function\n4. Life expectancy of \\> 12 weeks.\n5. Ability to comply with the requirements of the study.\n\nKey Exclusion Criteria:\n\n1. A diagnosis of acute promyelocytic leukemia.\n2. History of prior malignancy, with the exception of either a history of MDS or MDS\u002FMPN that has transformed to AML, or other prior malignancy that was treated with a full curative intent and no evidence of recurrence within the past 2 years (eg, localized skin cancer, superficial bladder cancer, carcinoma in situ of the cervix or breast, or localized Gleason score ≤ 6 prostate cancer)\n3. Antecedent MPN including myelofibrosis, essential thrombocytosis, polycythemia vera, or chronic myelogenous leukemia with or without BCR-ABL1 translocation and AML with BCR-ABL1 translocation.\n4. Prior therapy with a B-cell lymphoma-2 inhibitor\n5. Known central nervous system involvement by leukemia.\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":498,"type":499},260,"ESTIMATED","INTERVENTIONAL",[502,503],"PHASE1","PHASE2","The study will determine the safety, tolerability, recommended Phase 2 dose (RP2D) and preliminary efficacy of BGB-11417 as monotherapy and in combination with azacitidine in participants with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)or MDS\u002Fmyeloproliferative neoplasm (MPN) .",[506,507,508],"Acute Myeloid Leukemia","Myelodysplastic Syndromes","Myelodysplastic\u002FMyeloproliferative Neoplasm",[31,37,42,510,511,512],"AML","MDS","MDS\u002FMPN","2026-07-10",{"date":515,"type":516},"2026-07-13","ACTUAL",{"date":518,"type":516},"2021-05-24",{"date":520,"type":499},"2028-02-08",{"name":5,"class":6},46]