[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525057":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":40,"locations":46,"responsibleParty":188,"collaborators":26,"id":190,"slug":26,"hasResults":191,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":26,"eligibilityCriteria":195,"healthyVolunteers":191,"sex":196,"minAge":197,"maxAge":26,"enrollmentInfo":198,"targetDuration":26,"studyType":201,"phases":202,"briefSummary":204,"conditions":205,"keywords":26,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":216},{"fullName":5,"class":6},"Johnson & Johnson Enterprise Innovation Inc.","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1: JNJ-86974680+Cetrelimab","EXPERIMENTAL","Participants will receive JNJ-86974680 alone (dose 1, dose 2, dose 3, and dose 4) daily in 4 cohorts and then along with a set dose of cetrelimab.",[13,14],"Drug: JNJ-86974680","Drug: Cetrelimab",{"label":16,"type":10,"description":17,"interventionNames":18},"Part 2: JNJ-86974680+Cetrelimab+Radiation Therapy (RT)","Part 2 will consist of 3 cohorts (A, B and C) and participants will receive treatment with the selected dose of JNJ-86974680 in combination with cetrelimab from part 1, in conjunction with radiation.",[13,14,19],"Radiation: Radiation Therapy",[21,27,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","JNJ-86974680","JNJ-86974680 will be administered.",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Cetrelimab","Cetrelimab will be administered.",[9,16],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":26},"RADIATION","Radiation Therapy","Radiation therapy will be administered.",[16],[37],{"name":38,"affiliation":5,"role":39},"Johnson & Johnson Enterprise Innovation, Inc Clinical Trial","STUDY_DIRECTOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":26,"email":45},"Study Contact","CONTACT","844-434-4210","Participate-In-This-Study1@its.jnj.com",[47,60,70,80,88,98,108,118,129,138,148,154,164,170,179],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":26},"City of Hope 1","RECRUITING","Newnan","Georgia","30265","United States",{"type":55,"coordinates":56},"Point",[57,58],-84.79966,33.38067,{"lat":58,"lon":57},{"facility":61,"status":49,"city":62,"state":63,"zip":64,"country":53,"cosmosGeoPoint":65,"geoPoint":69,"contacts":26},"Hackensack University Medical Center","Hackensack","New Jersey","07601",{"type":55,"coordinates":66},[67,68],-74.04347,40.88593,{"lat":68,"lon":67},{"facility":71,"status":49,"city":72,"state":73,"zip":74,"country":53,"cosmosGeoPoint":75,"geoPoint":79,"contacts":26},"Roswell Park Comprehensive Cancer Center","Buffalo","New 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University","Philadelphia","Pennsylvania","19107",{"type":55,"coordinates":104},[105,106],-75.16362,39.95238,{"lat":106,"lon":105},{"facility":109,"status":49,"city":110,"state":111,"zip":112,"country":53,"cosmosGeoPoint":113,"geoPoint":117,"contacts":26},"Next Virginia","Fairfax","Virginia","22031",{"type":55,"coordinates":114},[115,116],-77.30637,38.84622,{"lat":116,"lon":115},{"facility":119,"status":120,"city":121,"state":26,"zip":122,"country":123,"cosmosGeoPoint":124,"geoPoint":128,"contacts":26},"Charite Research Organisation GmbH","COMPLETED","Berlin","12203","Germany",{"type":55,"coordinates":125},[126,127],13.41053,52.52437,{"lat":127,"lon":126},{"facility":130,"status":49,"city":131,"state":26,"zip":132,"country":123,"cosmosGeoPoint":133,"geoPoint":137,"contacts":26},"Universitaetsklinikum Giessen und Marburg GmbH","Giessen","35392",{"type":55,"coordinates":134},[135,136],8.67554,50.58727,{"lat":136,"lon":135},{"facility":139,"status":49,"city":140,"state":26,"zip":141,"country":142,"cosmosGeoPoint":143,"geoPoint":147,"contacts":26},"Severance Hospital Yonsei University Health System","Seoul","03722","South Korea",{"type":55,"coordinates":144},[145,146],126.9784,37.566,{"lat":146,"lon":145},{"facility":149,"status":49,"city":140,"state":26,"zip":150,"country":142,"cosmosGeoPoint":151,"geoPoint":153,"contacts":26},"Samsung Medical Center","06351",{"type":55,"coordinates":152},[145,146],{"lat":146,"lon":145},{"facility":155,"status":49,"city":156,"state":26,"zip":157,"country":158,"cosmosGeoPoint":159,"geoPoint":163,"contacts":26},"Hosp. Univ. Quiron Dexeus","Barcelona","08028","Spain",{"type":55,"coordinates":160},[161,162],2.15899,41.38879,{"lat":162,"lon":161},{"facility":165,"status":49,"city":156,"state":26,"zip":166,"country":158,"cosmosGeoPoint":167,"geoPoint":169,"contacts":26},"Hosp Univ Vall D Hebron","8035",{"type":55,"coordinates":168},[161,162],{"lat":162,"lon":161},{"facility":171,"status":49,"city":172,"state":26,"zip":173,"country":158,"cosmosGeoPoint":174,"geoPoint":178,"contacts":26},"Hosp. Univ. 12 de Octubre","Madrid","28041",{"type":55,"coordinates":175},[176,177],-3.70256,40.4165,{"lat":177,"lon":176},{"facility":180,"status":49,"city":181,"state":26,"zip":182,"country":158,"cosmosGeoPoint":183,"geoPoint":187,"contacts":26},"Hosp. Univ. I Politecni La Fe","Valencia","46026",{"type":55,"coordinates":184},[185,186],-0.37966,39.47391,{"lat":186,"lon":185},{"type":189,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100525057",false,"NCT06116786","A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer","A Phase 1 Study of JNJ-86974680, an A2a Receptor Antagonist, Administered as Monotherapy and in Combination With Cetrelimab and Radiotherapy for Advanced Non-Small Cell Lung Cancer","Inclusion Criteria:\n\n* Individuals with histologically or cytologically confirmed stage IIIB-IV non-small cell lung cancer (NSCLC)\n* Part 1: NSCLC with a known actionable genetic mutation (for example, epidermal growth factor receptor \\[EGFR\\], anaplastic lymphoma kinase \\[ALK\\], c-ros oncogene 1 \\[ROS1\\], v-raf murine sarcoma viral oncogene homolog B1 \\[BRAF\\]) must have received all approved targeted therapies and have progressed\n* Part 2: No targetable mutations (for example, EGFR \\[epidermal growth factor receptor\\], ALK \\[anaplastic lymphoma kinase\\], ROS1\\[c-ros oncogene 1\\], and BRAF \\[B-Raf proto-oncogene, serine\u002Fthreonine kinase\\])\n* Part 1 and Cohort A of part 2: Must have been treated with (a) anti-programmed death protein 1 (anti-PD-1) or programmed cell death ligand 1 (PD-L1) therapy and (b) platinum-based chemotherapy\n* For Cohort B of Part 2: Previously treated with anti-PD-1\u002FPD-L1 therapy for metastatic disease as the prior line of therapy\n* For Cohort C of Part 2: Treatment naïve\n* Adequate organ function\n\nExclusion Criteria:\n\n* Active central nervous system (CNS) disease involvement\n* Active autoimmune disease\n* Active infection\n* History of solid organ or hematologic stem cell transplantation","ALL","18 Years",{"count":199,"type":200},126,"ESTIMATED","INTERVENTIONAL",[203],"PHASE1","The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy.",[206],"Carcinoma, Non-small-Cell Lung","2026-06-19",{"date":209,"type":210},"2026-06-24","ACTUAL",{"date":212,"type":210},"2023-11-27",{"date":214,"type":200},"2029-06-07",{"name":5,"class":6},15]