About this trial

Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A\*02:01-restricted T cell receptor (TCR), targeting TP53 R175H mutant malignancies

Eligibility criteria

Qualifiers

Subjects must be at least 18 years of age

NSCLC

Colorectal adenocarcinoma

HNSCC

Disqualifiers

Any another primary malignancy within the 3 years prior to enrollment

Known, active primary central nervous system (CNS) malignancy

History of prior adoptive cell and gene therapy, allogeneic stem cell transplant or solid organ transplantation.

History of clinically significant cardiac disease within the 6 months prior to enrollment or heart failure at any time prior to enrollment.

Trial design

Treatments tested in this trial

  • NT-175

Treatment groups

45 Participants
are divided into 1 treatment group

Locations

18
Arizona
Research Site85234, Gilbert United States
California
Research Site91010, Duarte United States
Research Site92663, Newport Beach United States
Research Site90404, Santa Monica United States

Sponsors and collaborators

AstraZeneca

Lead sponsor