[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639398":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":53,"slug":26,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":26,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"AbbVie","INDUSTRY",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1-Bretisilocin-Japanese","EXPERIMENTAL","Participants will receive bretisilocin intramuscular (IM) injection on day 1.",[13],"Drug: Bretisilocin",{"label":15,"type":10,"description":11,"interventionNames":16},"Group 1-Bretisilocin-Han Chinese",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Group 1-Bretisilocin-Non-Asian",[13],[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Bretisilocin","Intramuscular Injection",[15,9,18],null,[28],{"name":29,"affiliation":5,"role":30},"ABBVIE INC.","STUDY_DIRECTOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"ABBVIE CALL CENTER","CONTACT","844-663-3742","abbvieclinicaltrials@abbvie.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":26},"CenExel Collaborative Neuroscience Research \u002FID# 281612","RECRUITING","Los Alamitos","California","90720","United States",{"type":46,"coordinates":47},"Point",[48,49],-118.07256,33.80307,{"lat":49,"lon":48},{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100639398",false,"NCT07604558","A Study to Assess the Adverse Events and How Bretisilocin Intramuscular Injection Moves Through the Body of Healthy Adult Participants","An Open-Label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Single Dose of Bretisilocin in Healthy Adult Japanese, Han Chinese, and Non-Asian Volunteers","Inclusion Criteria:\n\n* Group 1: Healthy adult Japanese male or female;\n\n  • Japanese participants must be first-generation Japanese of full Japanese parentage residing outside of Japan for less than 5 years.\n* Group 2: Healthy adult Han Chinese male or female\n\n  • Han Chinese participants must be first-generation Han Chinese of full Chinese parentage residing outside of China for less than 5 years.\n* Group 3: Healthy adult male or female volunteers of African, European, or Latin American descent.\n* A condition of general good health, based upon the results of a medical history, physical and neurological examination, vital signs, laboratory profile and 12-lead ECG.\n\nExclusion Criteria:\n\n* Current diagnosis or history of any clinically significant mental health disorder, cardiovascular disorder, metabolic disorder, or other disorder requiring pharmacologic or other medical treatment. (Previous psychological support without a diagnosed history of a mental health disorder would not be considered exclusionary.)\n* Clinically significant personal or familial history (first degree relative) of epilepsy, seizures, convulsions, or other seizure disorder (excluding febrile seizures as a child), previous head trauma or other risk factor for seizure (e.g., electrolyte disturbances, or structural neurological disorders).\n* Any use of psychoactive substances (including ketamine, esketamine, MDMA, cannabinoids, or nitrous oxide) during the 6 weeks prior to confinement.",true,"ALL","18 Years","65 Years",{"count":64,"type":65},26,"ESTIMATED","INTERVENTIONAL",[68],"PHASE1","This study will assess the adverse events, tolerability, and how bretisilocin intramuscular (IM) Injection moves through the body of healthy adult Japanese, Han Chinese, and Non-Asian volunteers participants.",[71],"Healthy Volunteer",[71,23,73],"ABBV-2505","2026-06-22",{"date":76,"type":77},"2026-06-24","ACTUAL",{"date":79,"type":77},"2026-05-26",{"date":81,"type":65},"2026-09",{"name":5,"class":6},1]