[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557756":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":290,"collaborators":20,"id":292,"slug":20,"hasResults":293,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":293,"sex":299,"minAge":300,"maxAge":20,"enrollmentInfo":301,"targetDuration":20,"studyType":304,"phases":305,"briefSummary":308,"conditions":309,"keywords":311,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":333},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Module 1: AZD5492 Monotherapy","EXPERIMENTAL","AZD5492 monotherapy for Relapsed or Refractory B-Cell Malignancies.",[13],"Drug: AZD5492",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","AZD5492","CD8\u002FTCR based T-cell engaging antibody targeting CD20, which is administered subcutaneously",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[28,41,51,61,70,78,83,92,100,109,118,127,135,145,154,163,172,180,189,198,206,215,223,231,240,248,257,265,274,282],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":20},"Research Site","RECRUITING","La Jolla","California","92093","United States",{"type":36,"coordinates":37},"Point",[38,39],-117.2742,32.84727,{"lat":39,"lon":38},{"facility":29,"status":42,"city":43,"state":44,"zip":45,"country":34,"cosmosGeoPoint":46,"geoPoint":50,"contacts":20},"WITHDRAWN","Boston","Massachusetts","02215",{"type":36,"coordinates":47},[48,49],-71.05977,42.35843,{"lat":49,"lon":48},{"facility":29,"status":52,"city":53,"state":54,"zip":55,"country":34,"cosmosGeoPoint":56,"geoPoint":60,"contacts":20},"NOT_YET_RECRUITING","Rochester","Minnesota","55905",{"type":36,"coordinates":57},[58,59],-92.4699,44.02163,{"lat":59,"lon":58},{"facility":29,"status":30,"city":62,"state":63,"zip":64,"country":34,"cosmosGeoPoint":65,"geoPoint":69,"contacts":20},"Hackensack","New Jersey","07601",{"type":36,"coordinates":66},[67,68],-74.04347,40.88593,{"lat":68,"lon":67},{"facility":29,"status":30,"city":71,"state":71,"zip":72,"country":34,"cosmosGeoPoint":73,"geoPoint":77,"contacts":20},"New York","10021",{"type":36,"coordinates":74},[75,76],-74.00597,40.71427,{"lat":76,"lon":75},{"facility":29,"status":30,"city":71,"state":71,"zip":79,"country":34,"cosmosGeoPoint":80,"geoPoint":82,"contacts":20},"10029",{"type":36,"coordinates":81},[75,76],{"lat":76,"lon":75},{"facility":29,"status":30,"city":84,"state":85,"zip":86,"country":34,"cosmosGeoPoint":87,"geoPoint":91,"contacts":20},"Charlotte","North Carolina","28203",{"type":36,"coordinates":88},[89,90],-80.84313,35.22709,{"lat":90,"lon":89},{"facility":29,"status":30,"city":93,"state":85,"zip":94,"country":34,"cosmosGeoPoint":95,"geoPoint":99,"contacts":20},"Winston-Salem","27157",{"type":36,"coordinates":96},[97,98],-80.24422,36.09986,{"lat":98,"lon":97},{"facility":29,"status":30,"city":101,"state":102,"zip":103,"country":34,"cosmosGeoPoint":104,"geoPoint":108,"contacts":20},"Houston","Texas","77030",{"type":36,"coordinates":105},[106,107],-95.36327,29.76328,{"lat":107,"lon":106},{"facility":29,"status":30,"city":110,"state":111,"zip":112,"country":34,"cosmosGeoPoint":113,"geoPoint":117,"contacts":20},"Seattle","Washington","98109",{"type":36,"coordinates":114},[115,116],-122.33207,47.60621,{"lat":116,"lon":115},{"facility":29,"status":30,"city":119,"state":20,"zip":120,"country":121,"cosmosGeoPoint":122,"geoPoint":126,"contacts":20},"Melbourne","3000","Australia",{"type":36,"coordinates":123},[124,125],144.96332,-37.814,{"lat":125,"lon":124},{"facility":29,"status":30,"city":128,"state":20,"zip":129,"country":121,"cosmosGeoPoint":130,"geoPoint":134,"contacts":20},"Nedlands","6009",{"type":36,"coordinates":131},[132,133],115.8073,-31.98184,{"lat":133,"lon":132},{"facility":29,"status":30,"city":136,"state":137,"zip":138,"country":139,"cosmosGeoPoint":140,"geoPoint":144,"contacts":20},"Calgary","Alberta","T2N 5G2","Canada",{"type":36,"coordinates":141},[142,143],-114.08529,51.05011,{"lat":143,"lon":142},{"facility":29,"status":30,"city":146,"state":147,"zip":148,"country":139,"cosmosGeoPoint":149,"geoPoint":153,"contacts":20},"Toronto","Ontario","M5G 2M9",{"type":36,"coordinates":150},[151,152],-79.39864,43.70643,{"lat":152,"lon":151},{"facility":29,"status":30,"city":155,"state":156,"zip":157,"country":139,"cosmosGeoPoint":158,"geoPoint":162,"contacts":20},"Montreal","Quebec","H3T 1R2",{"type":36,"coordinates":159},[160,161],-73.58781,45.50884,{"lat":161,"lon":160},{"facility":29,"status":30,"city":164,"state":20,"zip":165,"country":166,"cosmosGeoPoint":167,"geoPoint":171,"contacts":20},"Hangzhou","310003","China",{"type":36,"coordinates":168},[169,170],120.16142,30.29365,{"lat":170,"lon":169},{"facility":29,"status":30,"city":173,"state":20,"zip":174,"country":166,"cosmosGeoPoint":175,"geoPoint":179,"contacts":20},"Shanghai","200025",{"type":36,"coordinates":176},[177,178],121.45806,31.22222,{"lat":178,"lon":177},{"facility":29,"status":30,"city":181,"state":20,"zip":182,"country":183,"cosmosGeoPoint":184,"geoPoint":188,"contacts":20},"København Ø","2100","Denmark",{"type":36,"coordinates":185},[186,187],12.56862,55.70968,{"lat":187,"lon":186},{"facility":29,"status":30,"city":190,"state":20,"zip":191,"country":192,"cosmosGeoPoint":193,"geoPoint":197,"contacts":20},"Pessac","33604","France",{"type":36,"coordinates":194},[195,196],-0.6324,44.80565,{"lat":196,"lon":195},{"facility":29,"status":30,"city":199,"state":20,"zip":200,"country":192,"cosmosGeoPoint":201,"geoPoint":205,"contacts":20},"Villejuif","94805",{"type":36,"coordinates":202},[203,204],2.35992,48.7939,{"lat":204,"lon":203},{"facility":29,"status":30,"city":207,"state":20,"zip":208,"country":209,"cosmosGeoPoint":210,"geoPoint":214,"contacts":20},"München","81675","Germany",{"type":36,"coordinates":211},[212,213],13.31243,51.60698,{"lat":213,"lon":212},{"facility":29,"status":30,"city":216,"state":20,"zip":217,"country":209,"cosmosGeoPoint":218,"geoPoint":222,"contacts":20},"Ulm","89081",{"type":36,"coordinates":219},[220,221],9.99155,48.39841,{"lat":221,"lon":220},{"facility":29,"status":30,"city":224,"state":20,"zip":225,"country":209,"cosmosGeoPoint":226,"geoPoint":230,"contacts":20},"Würzburg","97080",{"type":36,"coordinates":227},[228,229],9.95121,49.79391,{"lat":229,"lon":228},{"facility":29,"status":30,"city":232,"state":20,"zip":233,"country":234,"cosmosGeoPoint":235,"geoPoint":239,"contacts":20},"Bologna","40138","Italy",{"type":36,"coordinates":236},[237,238],11.33875,44.49381,{"lat":238,"lon":237},{"facility":29,"status":30,"city":241,"state":20,"zip":242,"country":234,"cosmosGeoPoint":243,"geoPoint":247,"contacts":20},"Milan","20133",{"type":36,"coordinates":244},[245,246],12.59836,42.78235,{"lat":246,"lon":245},{"facility":29,"status":30,"city":249,"state":20,"zip":250,"country":251,"cosmosGeoPoint":252,"geoPoint":256,"contacts":20},"Chūōku","104-0045","Japan",{"type":36,"coordinates":253},[254,255],130.67068,33.63867,{"lat":255,"lon":254},{"facility":29,"status":30,"city":258,"state":20,"zip":259,"country":251,"cosmosGeoPoint":260,"geoPoint":264,"contacts":20},"Kashiwa","277-8577",{"type":36,"coordinates":261},[262,263],139.97732,35.86224,{"lat":263,"lon":262},{"facility":29,"status":30,"city":266,"state":20,"zip":267,"country":268,"cosmosGeoPoint":269,"geoPoint":273,"contacts":20},"Barcelona","08035","Spain",{"type":36,"coordinates":270},[271,272],2.15899,41.38879,{"lat":272,"lon":271},{"facility":29,"status":30,"city":275,"state":20,"zip":276,"country":268,"cosmosGeoPoint":277,"geoPoint":281,"contacts":20},"L'Hospitalet de Llobregat","08908",{"type":36,"coordinates":278},[279,280],2.10028,41.35967,{"lat":280,"lon":279},{"facility":29,"status":30,"city":283,"state":20,"zip":284,"country":268,"cosmosGeoPoint":285,"geoPoint":289,"contacts":20},"Madrid","28040",{"type":36,"coordinates":286},[287,288],-3.70256,40.4165,{"lat":288,"lon":287},{"type":291,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100557756",false,"NCT06542250","A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R\u002FR B-Cell Malignancies.","A Modular Phase I\u002FII Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With Relapsed or Refractory B-Cell Malignancies (TITANium)","TITANium","Inclusion Criteria:\n\n* ≥18 years of age;\n* Histologically documented CD20+ mature B-cell neoplasm\n\n  * Large B-cell lymphoma\n  * Follicular lymphoma\n  * Mantle cell lymphoma\n  * Chronic lymphocytic leukemia\n  * Small lymphocytic lymphoma\n* Relapsed, progressive and\u002For refractory disease following at least 2 prior lines of therapy;\n* ECOG performance status of ≤ 2 (\\\u003C 2 in EU countries).\n\nThe above is a summary, other inclusion criteria details may apply.\n\nExclusion Criteria:\n\n* Any neoplasm histology not specified in the IC section;\n* Active CNS involvement in lymphoma;\n* CNS pathology including but not limited to any history of seizure disorder\u002Fepilepsy;\n* Prior allogeneic HSCT within 180 days, prior autologous HSCT within 90 days, or cell therapy within 90 days of start of therapy;\n* History of Grade ≥ 3 CRS or Grade ≥ 3 ICANS;\n* Active and uncontrolled infections;\n* Unresolved AEs ≥2 Grade due to prior anticancer therapies, with some exceptions\n\nThe above is a summary, other exclusion criteria details may apply.","ALL","18 Years",{"count":302,"type":303},174,"ESTIMATED","INTERVENTIONAL",[306,307],"PHASE1","PHASE2","This is a Phase I\u002FII study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.",[310],"B-cell Malignancies",[312,313,314,315,17,316,317,318,319,320,321,322,297,323],"CD20","CD8","T cell engager","TCR","Relapsed, Refractory","B-cell malignancies","CLL, Chronic lymphocytic leukemia","SLL, Small lymphocytic lymphoma","MCL, Mantle cell lymphoma","LBCL, Large B-cell lymphoma","FL, Follicular lymphoma","TCE","2026-04-30",{"date":326,"type":327},"2026-05-01","ACTUAL",{"date":329,"type":327},"2024-09-18",{"date":331,"type":303},"2028-02-14",{"name":5,"class":6},30]