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Biopsies are mandatory depending on the cohorts.\n* Presence of measurable disease according to RECIST v1.1.\n\nExclusion Criteria:\n\n* Any known additional malignancy that is progressing or requires active treatment, or history of other malignancy within 2 years.\n* Not recovered to ≤ Grade 1 or baseline from residual toxicities of prior therapy.\n* Has active autoimmune disease requiring systemic immunosuppression with corticosteroids.\n* Brain or CNS metastases untreated or that have progressed.\n* History of organ transplant, including allogeneic stem cell transplantation.\n* History of clinically significant or uncontrolled cardiac disease.\n* Active HBV, active HCV, or HIV positive.\n* Is on chronic systemic steroids (\\> 10 mg\u002Fday of prednisone or equivalent).\n* Chronic or current active infectious disease requiring systemic antibiotics, antifungal, or antiviral treatment\n* Participants that have been initiated on or had modifications in anticoagulation therapies within the last 3 months prior to first dose of treatment.\n* Significant concurrent, uncontrolled medical condition, eg:\n\n  * Cardiovascular: Participants with known vasculitis, aneurisms, and other vascular malformations of clinical significance or history of myocarditis.\n  * Gastrointestinal: Any bowel obstruction within 60 days prior to C1D1.\n* Participants with adequate laboratory values within the protocol defined ranges.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","ALL","18 Years",{"count":417,"type":418},408,"ESTIMATED","INTERVENTIONAL",[421],"PHASE1","To evaluate the safety, tolerability, and DLTs and determine the MTD and\u002For RDE(s) of INCA33890 in participants with select advanced or metastatic solid tumors.",[424,425,426],"Solid Tumors","Advanced Solid Tumors","Metastatic Solid Tumors",[424,52],"2025-12-11",{"date":430,"type":431},"2025-12-18","ACTUAL",{"date":433,"type":431},"2023-07-24",{"date":435,"type":418},"2027-01-13",{"name":5,"class":6},36]