[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564854":3},{"organization":4,"armGroups":7,"interventions":47,"overallOfficials":73,"centralContacts":77,"locations":82,"responsibleParty":546,"collaborators":53,"id":548,"slug":53,"hasResults":549,"nctId":550,"briefTitle":551,"officialTitle":552,"acronym":53,"eligibilityCriteria":553,"healthyVolunteers":549,"sex":554,"minAge":555,"maxAge":53,"enrollmentInfo":556,"targetDuration":53,"studyType":559,"phases":560,"briefSummary":563,"conditions":564,"keywords":569,"overallStatus":85,"whyStopped":53,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":586},{"fullName":5,"class":6},"BeOne Medicines","INDUSTRY",[8,15,19,24,28,33,37,43],{"label":9,"type":10,"description":11,"interventionNames":12},"Substudy 1 Part 1a: Dose Escalation","EXPERIMENTAL","Sequential cohorts of increasing dose level combinations of BGB-16673 and sonrotoclax will be evaluated in participants with selected B-cell malignancies.",[13,14],"Drug: BGB-16673","Drug: Sonrotoclax",{"label":16,"type":10,"description":17,"interventionNames":18},"Substudy 1 Part 1b: Safety Expansion","Cohorts of select dose level combinations of BGB-16673 and sonrotoclax will be evaluated in participants with selected B-cell malignancies.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Substudy 2 Part 1a: Dose Escalation","Sequential cohorts of increasing dose level combinations of BGB-16673 and zanubrutinib will be evaluated in participants with selected B-cell malignancies.",[13,23],"Drug: Zanubrutinib",{"label":25,"type":10,"description":26,"interventionNames":27},"Substudy 2 Part 1b: Safety Expansion","Cohorts of select dose level combinations of BGB-16673 and zanubrutinib will be evaluated in participants with selected B-cell malignancies.",[13,23],{"label":29,"type":10,"description":30,"interventionNames":31},"Substudy 3 Part 1a: Dose Escalation","Sequential cohorts of increasing dose level combinations of BGB-16673 and mosunetuzumab will be evaluated in participants with selected B-cell malignancies.",[13,32],"Drug: Mosunetuzumab",{"label":34,"type":10,"description":35,"interventionNames":36},"Substudy 3 Part 1b: Safety Expansion","Cohorts of select dose level combinations of BGB-16673 and mosunetuzumab will be evaluated in participants with selected B-cell malignancies.",[13,32],{"label":38,"type":10,"description":39,"interventionNames":40},"Substudy 4 Part 1a: Dose Escalation","Sequential cohorts of increasing dose level combinations of BGB-16673 and glofitamab will be evaluated in participants with selected B-cell malignancies. Participants will receive obinutuzumab as pretreatment prior to the start of combination treatment.",[13,41,42],"Drug: Glofitamab","Drug: Obinutuzumab",{"label":44,"type":10,"description":45,"interventionNames":46},"Substudy 4 Part 1b: Safety Expansion","Cohorts of select dose level combinations of BGB-16673 and glofitamab will be evaluated in participants with selected B-cell malignancies.",[13,41,42],[48,54,59,62,66,70],{"type":49,"name":50,"description":51,"armGroupLabels":52,"otherNames":53},"DRUG","BGB-16673","Administered orally",[9,16,20,25,29,34,38,44],null,{"type":49,"name":55,"description":51,"armGroupLabels":56,"otherNames":57},"Sonrotoclax",[9,16],[58],"BGB-11417",{"type":49,"name":60,"description":51,"armGroupLabels":61,"otherNames":53},"Zanubrutinib",[20,25],{"type":49,"name":63,"description":64,"armGroupLabels":65,"otherNames":53},"Mosunetuzumab","Administered subcutaneously",[29,34],{"type":49,"name":67,"description":68,"armGroupLabels":69,"otherNames":53},"Glofitamab","Administered intravenously",[38,44],{"type":49,"name":71,"description":68,"armGroupLabels":72,"otherNames":53},"Obinutuzumab",[38,44],[74],{"name":75,"affiliation":5,"role":76},"Study Director","STUDY_DIRECTOR",[78],{"name":75,"role":79,"phone":80,"phoneExt":53,"email":81},"CONTACT","1.877.828.5568","clinicaltrials@beonemed.com",[83,96,106,116,125,135,145,155,165,174,180,186,192,200,210,220,230,240,249,260,270,280,289,295,305,315,324,333,342,353,363,373,383,392,402,411,420,429,438,448,457,466,475,484,494,500,510,519,528,537],{"facility":84,"status":85,"city":86,"state":87,"zip":88,"country":89,"cosmosGeoPoint":90,"geoPoint":95,"contacts":53},"Mayo Clinic Phoenix","RECRUITING","Phoenix","Arizona","85054-4502","United States",{"type":91,"coordinates":92},"Point",[93,94],-112.07404,33.44838,{"lat":94,"lon":93},{"facility":97,"status":85,"city":98,"state":99,"zip":100,"country":89,"cosmosGeoPoint":101,"geoPoint":105,"contacts":53},"University of Southern California Norris Comprehensive","Los Angeles","California","90033",{"type":91,"coordinates":102},[103,104],-118.24368,34.05223,{"lat":104,"lon":103},{"facility":107,"status":85,"city":108,"state":109,"zip":110,"country":89,"cosmosGeoPoint":111,"geoPoint":115,"contacts":53},"Mayo Clinic Jacksonville","Jacksonville","Florida","32224-1865",{"type":91,"coordinates":112},[113,114],-81.65565,30.33218,{"lat":114,"lon":113},{"facility":117,"status":85,"city":118,"state":109,"zip":119,"country":89,"cosmosGeoPoint":120,"geoPoint":124,"contacts":53},"Moffitt Cancer Center","Tampa","33612-9496",{"type":91,"coordinates":121},[122,123],-82.45843,27.94752,{"lat":123,"lon":122},{"facility":126,"status":85,"city":127,"state":128,"zip":129,"country":89,"cosmosGeoPoint":130,"geoPoint":134,"contacts":53},"The University of Kansas Cancer Center","Westwood","Kansas","66205-2003",{"type":91,"coordinates":131},[132,133],-94.6169,39.04056,{"lat":133,"lon":132},{"facility":136,"status":85,"city":137,"state":138,"zip":139,"country":89,"cosmosGeoPoint":140,"geoPoint":144,"contacts":53},"Mayo Clinic Rochester","Rochester","Minnesota","55905-0001",{"type":91,"coordinates":141},[142,143],-92.4699,44.02163,{"lat":143,"lon":142},{"facility":146,"status":85,"city":147,"state":148,"zip":149,"country":89,"cosmosGeoPoint":150,"geoPoint":154,"contacts":53},"Washington University School of Medicine","St Louis","Missouri","63110-1010",{"type":91,"coordinates":151},[152,153],-90.19789,38.62727,{"lat":153,"lon":152},{"facility":156,"status":85,"city":157,"state":158,"zip":159,"country":89,"cosmosGeoPoint":160,"geoPoint":164,"contacts":53},"Summit Medical Group","Florham Park","New Jersey","07932-1049",{"type":91,"coordinates":161},[162,163],-74.38821,40.78788,{"lat":163,"lon":162},{"facility":166,"status":85,"city":167,"state":167,"zip":168,"country":89,"cosmosGeoPoint":169,"geoPoint":173,"contacts":53},"Icahn School of Medicine At Mount Sinai","New York","10029-6504",{"type":91,"coordinates":170},[171,172],-74.00597,40.71427,{"lat":172,"lon":171},{"facility":175,"status":85,"city":167,"state":167,"zip":176,"country":89,"cosmosGeoPoint":177,"geoPoint":179,"contacts":53},"Columbia University Medical Center","10032",{"type":91,"coordinates":178},[171,172],{"lat":172,"lon":171},{"facility":181,"status":85,"city":167,"state":167,"zip":182,"country":89,"cosmosGeoPoint":183,"geoPoint":185,"contacts":53},"Weill Cornell Medical College Newyork Presbyterian Hospital","10065-4870",{"type":91,"coordinates":184},[171,172],{"lat":172,"lon":171},{"facility":187,"status":85,"city":167,"state":167,"zip":188,"country":89,"cosmosGeoPoint":189,"geoPoint":191,"contacts":53},"Memorial Sloan Kettering Cancer Center Mskcc","10065-6800",{"type":91,"coordinates":190},[171,172],{"lat":172,"lon":171},{"facility":193,"status":85,"city":137,"state":167,"zip":194,"country":89,"cosmosGeoPoint":195,"geoPoint":199,"contacts":53},"University of Rochester","14642-0001",{"type":91,"coordinates":196},[197,198],-77.61556,43.15478,{"lat":198,"lon":197},{"facility":201,"status":85,"city":202,"state":203,"zip":204,"country":89,"cosmosGeoPoint":205,"geoPoint":209,"contacts":53},"Fox Chase Cancer Center","Philadelphia","Pennsylvania","19111-2434",{"type":91,"coordinates":206},[207,208],-75.16362,39.95238,{"lat":208,"lon":207},{"facility":211,"status":85,"city":212,"state":213,"zip":214,"country":89,"cosmosGeoPoint":215,"geoPoint":219,"contacts":53},"The University of Texas Md Anderson Cancer Center","Houston","Texas","77030-4009",{"type":91,"coordinates":216},[217,218],-95.36327,29.76328,{"lat":218,"lon":217},{"facility":221,"status":85,"city":222,"state":223,"zip":224,"country":89,"cosmosGeoPoint":225,"geoPoint":229,"contacts":53},"Huntsman Cancer Institute","Salt Lake City","Utah","84112-5550",{"type":91,"coordinates":226},[227,228],-111.89105,40.76078,{"lat":228,"lon":227},{"facility":231,"status":85,"city":232,"state":233,"zip":234,"country":89,"cosmosGeoPoint":235,"geoPoint":239,"contacts":53},"University of Wisconsin","Madison","Wisconsin","53792-0001",{"type":91,"coordinates":236},[237,238],-89.40123,43.07305,{"lat":238,"lon":237},{"facility":241,"status":85,"city":242,"state":233,"zip":243,"country":89,"cosmosGeoPoint":244,"geoPoint":248,"contacts":53},"Medical College of Wisconsin","Milwaukee","53226-1222",{"type":91,"coordinates":245},[246,247],-87.90647,43.0389,{"lat":247,"lon":246},{"facility":250,"status":85,"city":251,"state":252,"zip":253,"country":254,"cosmosGeoPoint":255,"geoPoint":259,"contacts":53},"St George Hospital","Kogarah","New South Wales","NSW 2217","Australia",{"type":91,"coordinates":256},[257,258],151.13564,-33.9681,{"lat":258,"lon":257},{"facility":261,"status":85,"city":262,"state":263,"zip":264,"country":254,"cosmosGeoPoint":265,"geoPoint":269,"contacts":53},"Mater Cancer Care Centre","South Brisbane","Queensland","QLD 4101",{"type":91,"coordinates":266},[267,268],153.02049,-27.48034,{"lat":268,"lon":267},{"facility":271,"status":85,"city":272,"state":273,"zip":274,"country":254,"cosmosGeoPoint":275,"geoPoint":279,"contacts":53},"Monash Health","Clayton","Victoria","VIC 3168",{"type":91,"coordinates":276},[277,278],145.11667,-37.91667,{"lat":278,"lon":277},{"facility":281,"status":85,"city":282,"state":273,"zip":283,"country":254,"cosmosGeoPoint":284,"geoPoint":288,"contacts":53},"Peter Maccallum Cancer Centre","Melbourne","VIC 3000",{"type":91,"coordinates":285},[286,287],144.96332,-37.814,{"lat":287,"lon":286},{"facility":290,"status":85,"city":282,"state":273,"zip":291,"country":254,"cosmosGeoPoint":292,"geoPoint":294,"contacts":53},"The Alfred Hospital","VIC 3004",{"type":91,"coordinates":293},[286,287],{"lat":287,"lon":286},{"facility":296,"status":85,"city":297,"state":298,"zip":299,"country":254,"cosmosGeoPoint":300,"geoPoint":304,"contacts":53},"Linear Clinical Research","Nedlands","Western Australia","WA 6009",{"type":91,"coordinates":301},[302,303],115.8073,-31.98184,{"lat":303,"lon":302},{"facility":306,"status":85,"city":307,"state":53,"zip":308,"country":309,"cosmosGeoPoint":310,"geoPoint":314,"contacts":53},"Hospital Sirio Libanes Brasilia","Brasília","70200-730","Brazil",{"type":91,"coordinates":311},[312,313],-47.92972,-15.77972,{"lat":313,"lon":312},{"facility":316,"status":85,"city":317,"state":53,"zip":318,"country":309,"cosmosGeoPoint":319,"geoPoint":323,"contacts":53},"Ensino E Terapia de Inovacao Clinica Amo Etica","Salvador","41950-640",{"type":91,"coordinates":320},[321,322],-38.49096,-12.97563,{"lat":322,"lon":321},{"facility":325,"status":85,"city":326,"state":53,"zip":327,"country":309,"cosmosGeoPoint":328,"geoPoint":332,"contacts":53},"Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto","São José do Rio Preto","15090-000",{"type":91,"coordinates":329},[330,331],-49.37944,-20.81972,{"lat":331,"lon":330},{"facility":334,"status":85,"city":335,"state":53,"zip":336,"country":309,"cosmosGeoPoint":337,"geoPoint":341,"contacts":53},"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","São Paulo","05652-900",{"type":91,"coordinates":338},[339,340],-46.63611,-23.5475,{"lat":340,"lon":339},{"facility":343,"status":85,"city":344,"state":345,"zip":346,"country":347,"cosmosGeoPoint":348,"geoPoint":352,"contacts":53},"Fujian Medical University Union Hospital","Fuzhou","Fujian","350001","China",{"type":91,"coordinates":349},[350,351],119.30611,26.06139,{"lat":351,"lon":350},{"facility":354,"status":85,"city":355,"state":356,"zip":357,"country":347,"cosmosGeoPoint":358,"geoPoint":362,"contacts":53},"Sun Yat Sen University Cancer Center","Guangzhou","Guangdong","510060",{"type":91,"coordinates":359},[360,361],113.25,23.11667,{"lat":361,"lon":360},{"facility":364,"status":85,"city":365,"state":366,"zip":367,"country":347,"cosmosGeoPoint":368,"geoPoint":372,"contacts":53},"The First Affiliated Hospital of Soochow University","Suzhou","Jiangsu","215006",{"type":91,"coordinates":369},[370,371],120.59538,31.30408,{"lat":371,"lon":370},{"facility":374,"status":85,"city":375,"state":376,"zip":377,"country":347,"cosmosGeoPoint":378,"geoPoint":382,"contacts":53},"The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan","Hangzhou","Zhejiang","310002",{"type":91,"coordinates":379},[380,381],120.16142,30.29365,{"lat":381,"lon":380},{"facility":384,"status":85,"city":385,"state":376,"zip":386,"country":347,"cosmosGeoPoint":387,"geoPoint":391,"contacts":53},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","325000",{"type":91,"coordinates":388},[389,390],120.66682,27.99942,{"lat":390,"lon":389},{"facility":393,"status":85,"city":394,"state":53,"zip":395,"country":396,"cosmosGeoPoint":397,"geoPoint":401,"contacts":53},"Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden","Dresden","01307","Germany",{"type":91,"coordinates":398},[399,400],13.73832,51.05089,{"lat":400,"lon":399},{"facility":403,"status":85,"city":404,"state":53,"zip":405,"country":396,"cosmosGeoPoint":406,"geoPoint":410,"contacts":53},"Universitatsklinikum Jena Klinik Fur Innere Medizin Ii","Jena","07747",{"type":91,"coordinates":407},[408,409],11.5899,50.92878,{"lat":409,"lon":408},{"facility":412,"status":85,"city":413,"state":53,"zip":414,"country":396,"cosmosGeoPoint":415,"geoPoint":419,"contacts":53},"Universitatsklinikum Schleswig Holstein Campus Kiel","Kiel","24105",{"type":91,"coordinates":416},[417,418],10.13489,54.32133,{"lat":418,"lon":417},{"facility":421,"status":85,"city":422,"state":53,"zip":423,"country":396,"cosmosGeoPoint":424,"geoPoint":428,"contacts":53},"Medizinische Universitaetsklinik","Tübingen","72076",{"type":91,"coordinates":425},[426,427],9.05222,48.52266,{"lat":427,"lon":426},{"facility":430,"status":85,"city":431,"state":53,"zip":432,"country":396,"cosmosGeoPoint":433,"geoPoint":437,"contacts":53},"Universitaetsklinikum Ulm","Ulm","89081",{"type":91,"coordinates":434},[435,436],9.99155,48.39841,{"lat":436,"lon":435},{"facility":439,"status":85,"city":440,"state":53,"zip":441,"country":442,"cosmosGeoPoint":443,"geoPoint":447,"contacts":53},"Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi","Bologna","40138","Italy",{"type":91,"coordinates":444},[445,446],11.33875,44.49381,{"lat":446,"lon":445},{"facility":449,"status":85,"city":450,"state":53,"zip":451,"country":442,"cosmosGeoPoint":452,"geoPoint":456,"contacts":53},"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","Milan","20162",{"type":91,"coordinates":453},[454,455],12.59836,42.78235,{"lat":455,"lon":454},{"facility":458,"status":85,"city":459,"state":53,"zip":460,"country":442,"cosmosGeoPoint":461,"geoPoint":465,"contacts":53},"Istituto Nazionale Tumori Fondazione G Pascale","Naples","80131",{"type":91,"coordinates":462},[463,464],14.26811,40.85216,{"lat":464,"lon":463},{"facility":467,"status":85,"city":468,"state":53,"zip":469,"country":442,"cosmosGeoPoint":470,"geoPoint":474,"contacts":53},"Istituto Clinico Humanitas","Rozzano","20089",{"type":91,"coordinates":471},[472,473],9.1559,45.38193,{"lat":473,"lon":472},{"facility":476,"status":85,"city":477,"state":53,"zip":478,"country":442,"cosmosGeoPoint":479,"geoPoint":483,"contacts":53},"Centroricerche Cliniche Di Verona Srl","Verona","37134",{"type":91,"coordinates":480},[481,482],10.9938,45.43854,{"lat":482,"lon":481},{"facility":485,"status":85,"city":486,"state":53,"zip":487,"country":488,"cosmosGeoPoint":489,"geoPoint":493,"contacts":53},"North Shore Hospital","Auckland","0622","New Zealand",{"type":91,"coordinates":490},[491,492],174.76349,-36.84853,{"lat":492,"lon":491},{"facility":495,"status":85,"city":486,"state":53,"zip":496,"country":488,"cosmosGeoPoint":497,"geoPoint":499,"contacts":53},"Auckland City Hospital","1023",{"type":91,"coordinates":498},[491,492],{"lat":492,"lon":491},{"facility":501,"status":85,"city":502,"state":53,"zip":503,"country":504,"cosmosGeoPoint":505,"geoPoint":509,"contacts":53},"Uniwersyteckie Centrum Kliniczne","Gdansk","80-214","Poland",{"type":91,"coordinates":506},[507,508],18.64912,54.35227,{"lat":508,"lon":507},{"facility":511,"status":85,"city":512,"state":53,"zip":513,"country":504,"cosmosGeoPoint":514,"geoPoint":518,"contacts":53},"Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie","Lublin","20-081",{"type":91,"coordinates":515},[516,517],22.57009,51.25058,{"lat":517,"lon":516},{"facility":520,"status":85,"city":521,"state":53,"zip":522,"country":504,"cosmosGeoPoint":523,"geoPoint":527,"contacts":53},"Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii","Olsztyn","10-228",{"type":91,"coordinates":524},[525,526],20.49272,53.78376,{"lat":526,"lon":525},{"facility":529,"status":85,"city":530,"state":53,"zip":531,"country":504,"cosmosGeoPoint":532,"geoPoint":536,"contacts":53},"Szpital Wojewodzki W Opolu Sp Z Oo Oddzia Hematologii I Onkologii Hematologicznej","Opole","45-061",{"type":91,"coordinates":533},[534,535],17.92604,50.67119,{"lat":535,"lon":534},{"facility":538,"status":85,"city":539,"state":53,"zip":540,"country":504,"cosmosGeoPoint":541,"geoPoint":545,"contacts":53},"Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie Hematology Unit","Warsaw","02-781",{"type":91,"coordinates":542},[543,544],21.01178,52.22977,{"lat":544,"lon":543},{"type":547,"investigatorFullName":53,"investigatorTitle":53,"investigatorAffiliation":53,"oldNameTitle":53,"oldOrganization":53},"SPONSOR","100564854",false,"NCT06634589","A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies","A Phase 1b\u002F2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies","Key Inclusion Criteria:\n\n* Must sign the informed consent form (ICF) and be capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the ICF\n* Confirmed diagnosis of a R\u002FR B-cell malignancy\n* Protocol-defined measurable disease\n* Stable Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2\n* Adequate organ function\n* Female participants of childbearing potential must be willing to use a highly effective method of birth control and refrain from egg donation for the duration of the study and for ≥ 7 days after the last dose of sonrotoclax, 30 days after the last dose of BGB-16673 or zanubrutinib, 60 days after the last dose of glofitamab, or 90 days after the last dose of mosunetuzumab. A negative urine or serum pregnancy test result must be provided 10-14 days before the first dose of study treatment\n* Nonsterile male participants must be willing to use a highly effective method of birth control and refrain from sperm donation for the duration of the study and for ≥ 7 days after the last dose of sonrotoclax, 30 days after the last dose of BGB-16673 or zanubrutinib, 60 days after the last dose of glofitamab, or 90 days after the last dose of mosunetuzumab\n* Substudies 1, 3, and 4 Inclusion Criterion:\n\n  * Adequate renal function as indicated by estimated glomerular filtration rate (eGFR) of ≥ 50 mL\u002Fmin\n* Substudy 2 Inclusion Criteria:\n\n  * Bruton tyrosine kinase (BTK) inhibitor-naive, or previously received treatment with a covalent BTK inhibitor and discontinued for reasons other than clinical progression\n  * Adequate renal function as indicated by eGFR of ≥ 30 mL\u002Fmin\n\nKey Exclusion Criteria:\n\n* Treatment-naive B-cell malignancies\n* Unable to comply with the requirements of the protocol\n* Active leptomeningeal disease or uncontrolled, untreated brain metastasis\n* Any malignancy ≤ 2 years before first dose of study treatment except for the specific cancer under investigation in this study or any locally recurring cancer that has been treated curatively\n* Autologous stem cell transplant ≤ 3 months prior to screening or chimeric antigen T-cell therapy ≤ 3 months prior to screening\n* Prior invasive fungal infection, except if participant agrees to receive secondary antifungal prophylaxis during the entire treatment period\n* Substudies 1 and 2: Prior allogeneic stem cell transplant with active graft-versus-host disease (GVHD), or requiring immunosuppressive drugs for treatment of GVHD, or who have taken calcineurin inhibitors within 4 weeks prior to consent\n* Participants who have a history of severe allergic reactions or hypersensitivity to the active ingredient and excipients of BGB-16673, sonrotoclax, zanubrutinib, mosunetuzumab, or glofitamab\n* Substudy 1 Exclusion Criterion:\n\n  * Prior treatment with a B-cell lymphoma-2 (Bcl-2) inhibitor (with exception for participants who relapsed ≥ 24 months after completion of a full course of a prior Bcl-2 inhibitor containing regimen)\n* Substudy 2 Exclusion Criterion:\n\n  * Participants who discontinued prior zanubrutinib treatment due to intolerance\n* Substudies 3 and 4 Exclusion Criteria:\n\n  * Prior exposure to a CD20 x CD3 T-cell engager antibody treatment\n  * All participants with a prior allogeneic stem cell transplant\n  * Participants with known contraindications to azole antifungal agents, including hypersensitivity reactions\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":557,"type":558},80,"ESTIMATED","INTERVENTIONAL",[561,562],"PHASE1","PHASE2","The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with BGB-16673 in combination with other agents in participants with relapsed or refractory (R\u002FR) B-cell malignancies. This study is structured as a master protocol with separate substudies. This study currently includes four substudies, and more substudies may be added as other combination agents are identified.",[565,566,567,568],"B-cell Malignancy","Relapsed Cancer","Refractory Cancer","B-cell Lymphoma",[570,571,572,50,573,574,575,576,63,67],"R\u002FR B-Cell Malignancies","relapsed or refractory B-Cell Malignancies","B-Cell malignancy","sonrotoclax","zanubrutinib","B-cell lymphoma","Bruton Tyrosine Kinase (BTK)","2026-06-01",{"date":579,"type":580},"2026-06-03","ACTUAL",{"date":582,"type":580},"2024-11-27",{"date":584,"type":558},"2029-12-02",{"name":5,"class":6},50]