[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513189":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":41,"centralContacts":45,"locations":55,"responsibleParty":74,"collaborators":76,"id":80,"slug":30,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":30,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":30,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":58,"whyStopped":30,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"S-nicotine (tobacco) as the starting condition","EXPERIMENTAL","Participants will spend 8 hours in the hospital research ward where they will vape e-liquid containing 100% (S)-nicotine.",[13,14,15],"Drug: (S)-Nicotine","Drug: (R)- nicotine","Drug: Racemic nicotine",{"label":17,"type":10,"description":18,"interventionNames":19},"R-nicotine (synthetic) as the starting condition","Participants will spend 8 hours in the hospital research ward where they will vape e-liquid containing 100% (R)-nicotine.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Racemic (50:50 S- and R- nicotine) as the starting condition","Participants will spend 8 hours in the hospital research ward where they will vape e-liquid containing 50% (S)-nicotine and 50% (R)-nicotine.",[13,14,15],[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","(S)-Nicotine","Participants will spend 8 hours in the hospital research ward and will vape e-liquid containing 100% (S)-nicotine. They will vape following a standardized session, followed by a 4 hour abstinence period. Participants will then vape as they wish (ad libitum) for 90 minutes.",[17,21,9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"(R)- nicotine","Participants will spend 8 hours in the hospital research ward and will vape e-liquid containing 100% (R)-nicotine. They will vape following a standardized session, followed by a 4 hour abstinence period. Participants will then vape as they wish (ad libitum) for 90 minutes.",[17,21,9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Racemic nicotine","Participants will spend 8 hours in the hospital research ward and will vape e-liquid containing 50% (R)-nicotine and 50% (S)-nicotine. They will vape following a standardized session, followed by a 4 hour abstinence period. Participants will then vape as they wish (ad libitum) for 90 minutes.",[17,21,9],[40],"50:50 mixture of (S)- and (R)-nicotine",[42],{"name":43,"affiliation":5,"role":44},"Neal Benowitz, MD","PRINCIPAL_INVESTIGATOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":30,"email":50},"Lisa Lawrence","CONTACT","628-206-4204","lisa.lawrence@ucsf.edu",{"name":52,"role":48,"phone":53,"phoneExt":30,"email":54},"Armando Barraza","510-560-4842","armando.barraza@ucsf.edu",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Zuckerberg San Francisco General Hospital (ZSFG)","RECRUITING","San Francisco","California","94110","United States",{"type":64,"coordinates":65},"Point",[66,67],-122.41942,37.77493,{"lat":67,"lon":66},[70,72,73],{"name":47,"role":48,"phone":71,"phoneExt":30,"email":50},"415-502-2465",{"name":52,"role":48,"phone":71,"phoneExt":30,"email":54},{"name":43,"role":44,"phone":30,"phoneExt":30,"email":30},{"type":75,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[77],{"name":78,"class":79},"National Institute on Drug Abuse (NIDA)","NIH","100513189",false,"NCT05962229","Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine","Inclusion Criteria:\n\n* Healthy on the basis of medical history and limited physical examination.\n* Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)\n\nExclusion Criteria:\n\n* • Medications\n\n  * Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).\n  * Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).\n  * Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).\n  * Any stimulant medications (example: Adderall) generally given for ADHD treatment.\n\n    • Pregnancy\n  * Pregnancy (self-reported and urine pregnancy test)\n  * Breastfeeding (determined by self-report)\n  * Women of childbearing potential must be using an acceptable method of contraception\n\n    * Inability to read and write in English\n    * A known propylene glycol\u002Fvegetable glycerin allergy\n    * Uncomfortable with getting blood drawn",true,"ALL","21 Years","65 Years",{"count":90,"type":91},18,"ESTIMATED","INTERVENTIONAL",[94],"PHASE1","In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving\u002Fwithdrawal and enjoyment.",[97,98],"Nicotine Dependence","Nicotine Vaping",[100,101,102,103],"Nicotine Pharmacokinetics","Nicotine Pharmacodynamics","Vaping","E-cigarettes","2026-05-12",{"date":106,"type":107},"2026-05-14","ACTUAL",{"date":109,"type":107},"2024-12-06",{"date":111,"type":91},"2027-05",{"name":5,"class":6},1]