[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100410545":3},{"organization":4,"outcomesModule":7,"designInfo":125,"detailedDescription":131,"studyPopulation":124,"armGroups":132,"interventions":217,"overallOfficials":262,"centralContacts":267,"locations":276,"responsibleParty":1657,"collaborators":124,"id":1659,"slug":124,"hasResults":1660,"nctId":1661,"briefTitle":1662,"officialTitle":1662,"acronym":1663,"eligibilityCriteria":1664,"healthyVolunteers":1660,"sex":1665,"minAge":124,"maxAge":124,"enrollmentInfo":1666,"targetDuration":124,"studyType":1669,"phases":1670,"briefSummary":1673,"conditions":1674,"keywords":124,"overallStatus":279,"whyStopped":124,"lastUpdateSubmitDate":1676,"lastUpdatePostDateStruct":1677,"startDateStruct":1680,"completionDateStruct":1682,"leadSponsor":1684,"locationsCount":1685},{"fullName":5,"class":6},"University of Birmingham","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":32,"otherOutcomes":124},[9,13,15,17,19,22,26,30],{"measure":10,"description":11,"timeFrame":12},"Event Free Survival (RT2)","Failure events are:\n\n* Relapse or progression of existing disease, or occurrence of disease at new sites,\n* Death from any cause without disease progression,\n* Second malignant neoplasm","From randomisation to first failure event, timeframe 36 months",{"measure":14,"description":11,"timeFrame":12},"Event Free Survival (CT1A)",{"measure":16,"description":11,"timeFrame":12},"Event Free Survival (CT1B)",{"measure":18,"description":11,"timeFrame":12},"Event Free Survival (CT2A)",{"measure":20,"description":11,"timeFrame":21},"Event Free Survival (CT2B)","Time from randomisation to first failure event, timeframe 36 months",{"measure":23,"description":24,"timeFrame":25},"Event Free Survival (CT3)","To determine whether new systemic therapy regimens improve event free survival in relapsed RMS compared to standard therapy (VIRT) (CT3):\n\nInitial new systemic therapy combination to be tested:\n\no Regorafenib (R) added to vincristine and irinotecan (VIR) (VIRR)","Patients will be followed up for a minimum of 6 years from trial entry (or 5 years from end of relapsed trial treatment, whichever comes later). Patients will be followed up for progression and death until the end of trial definition has been met.",{"measure":27,"description":28,"timeFrame":29},"Local Failure Free Survival (RT1A and RT1B)","A local failure event is relapse or progression of tumour at the primary site at any time even if there has been a prior \u002Fconcurrent, regional or distant failure","Time from randomisation to first local failure event, timeframe 36 months",{"measure":31,"description":28,"timeFrame":29},"Local Failure Free Survival (RT1C)",[33,37,41,45,49,53,57,61,63,65,67,69,72,75,78,81,85,89,93,97,101,104,107,108,112,116,119,121],{"measure":34,"description":35,"timeFrame":36},"Recommended Phase II Dose (Phase 1b)","Based on tolerability, where tolerability is evaluated through the occurrence of dose limiting toxicity (DLT).","From first patient first visit in dose finding study until appropriate dose level found, estimated 9 months",{"measure":38,"description":39,"timeFrame":40},"Maximum Tolerated Dose (Phase 1b)","Dose level at which no or one participant experiences a DLT when at least two of three to six participants experience a DLT at the next highest dose.","From first patient first visit in dose finding study until appropriate dose level",{"measure":42,"description":43,"timeFrame":44},"Toxicity (All chemotherapy randomisations)","Categorised and graded using Common Terminology Criteria for Adverse Events","From date of protocol defined treatment until 30 days after the administration of the last treatment",{"measure":46,"description":47,"timeFrame":48},"Dose Limiting Toxicity (Phase 1b)","Diarrhoea: Grade 3 for \\>3 days despite loperamide therapy Diarrhoea: Grade 4 despite loperamide therapy. Enterocolitis: Grade 3 or above Ileus: Grade 3 or above for more than 3 days Oral mucositis: Grade 3 above for \\>3 days despite optimal supportive care Persistent neutropenia or thrombocytopenia leading to delay of start of next course by \\>7 days; i.e. starting \\> day 28 Any grade 3 or 4 toxicity resulting in discontinuation of the new combination Any grade 5 toxicity","From commencement of treatment until 21 days after the start of cycle 2 (each cycle is 21 days)",{"measure":50,"description":51,"timeFrame":52},"Response (Phase 1b, CT1A, CT1B)","defined as complete (CR) or partial response (PR) and is clinically defined. Patients who are not assessable for response - e.g. because of early stopping of treatment or death - will be assumed to be non-responders.","Response assessed after course 3 (63 days) and 6 (126 days)",{"measure":54,"description":55,"timeFrame":56},"Tolerability (CT3)","To determine the tolerability of the regimens.","From registration\u002Frandomisation until death\u002Fstudy endpoint",{"measure":58,"description":59,"timeFrame":60},"Overall Survival (CT1A)","Death from any cause","From randomisation to death from any cause, assessed for 36 months",{"measure":62,"description":59,"timeFrame":60},"Overall Survival (CT1B)",{"measure":64,"description":59,"timeFrame":60},"Overall Survival (CT2A)",{"measure":66,"description":59,"timeFrame":60},"Overall Survival (CT2B)",{"measure":68,"description":59,"timeFrame":60},"Overall Survival (RT1A and RT1B)",{"measure":70,"description":59,"timeFrame":71},"Overall Survival (RT1C)","From RT1C randomisation to death from any cause, assessed for 36 months",{"measure":73,"description":59,"timeFrame":74},"Overall Survival (RT2)","From RT2 randomisation to death from any cause, as assessed for 36 months",{"measure":76,"description":77,"timeFrame":25},"Overall Survival (CT3)","To evaluate the anti-tumour activity and effect on overall survival of VIRR when compared to standard therapy",{"measure":79,"description":59,"timeFrame":80},"Overall Survival (all patients)","From randomisation\u002Fregistration to death from any cause, assessed for 36 months",{"measure":82,"description":83,"timeFrame":84},"Acute wound complications and post-operative complications (RT1A and RT1B)","specific grade 3 and above complications according to CTCAE v 4 and Clavien Dindo scale. Specific wound complications within the same time frame will also be collected","Within 120 days from surgery",{"measure":86,"description":87,"timeFrame":88},"Acute post-radiotherapy complications (All radiotherapy randomisations)","any grade 3 and above event according to CTCAE v 4","Within 120 days from start of radiotherapy",{"measure":90,"description":91,"timeFrame":92},"Late complications (RT1A, RT1B. RT1C)","specific grade 3 and above events according to CTCAE and Clavien-Dindo scale","After 120 days from last local therapy",{"measure":94,"description":95,"timeFrame":96},"Loco-regional failure-free survival (All radiotherapy randomisations)","A local failure event is relapse or progression of tumour at the primary site at any time even if there has been a prior concurrent local, regional or distant failure. A regional event is relapse or progression of tumour at regional lymph nodes at any time even if there has been a prior distant failure.","From randomisation to first local and\u002For regional failure event, assessed for 36 months",{"measure":98,"description":99,"timeFrame":100},"Health related quality of life (RT1A and RT2) self-reported questionnaire completed by patient","will be assessed using Pediatric quality of life questionnaire (PedsQL) for the paediatric population (under 18 years). The minimum score is 0 where quality of life is completely unaffected by the intervention to 4 where quality of life is severely affected.","4 timepoints: 1) 1 day of start of radiotherapy, 2) at completion of radiotherapy, average 5 weeks after start of radiotherapy, 3) 3 months and 4) 24 months following radiotherapy",{"measure":102,"description":103,"timeFrame":100},"Health related quality of life (RT1A and RT2) self-reported questionnaire completed by the patient","will be assessed using European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire 30 (EORTC QLQ-C30) for patients 18 years of age and over. The minimum score is 0 where quality of life is completely unaffected by the intervention to 4 where quality of life is severely affected.",{"measure":105,"description":99,"timeFrame":106},"Health related quality of life (CT3) self-reported questionnaire completed by the patient","3 timepoints: Each Cycle is 28 days. Timepoint 1: Day 0 of cycle 1 (prior to starting treatment), Timepoint 2 day 0 cycle 3, Timepoint 3) day 0 cycle 5",{"measure":105,"description":103,"timeFrame":106},{"measure":109,"description":110,"timeFrame":111},"Acceptability and Palatability of Regorafenib (CT3)","\"Acceptability and Palatability Questionnaire\" To evaluate the acceptability and palatability of regorafenib formulations","1 timepoint: Day 8 of cycle 1 (Each Cycle is 28 days)",{"measure":113,"description":114,"timeFrame":115},"PET Response (if participating in PET Sub-study)","assessed by PERCIST criteria and visual 'Deauville like' criteria","After three cycles of chemotherapy (each cycle is 21 days)",{"measure":117,"description":11,"timeFrame":118},"Event Free Survival (all patients)","From date of randomisation\u002Fregistration to death from any cause, assessed for 36 months",{"measure":120,"description":11,"timeFrame":118},"Event Free Survival (if participating in PET Sub-study)",{"measure":122,"description":28,"timeFrame":123},"Local Failure Free Survival (if participating in PET Sub-study)","From date of randomisation\u002Fregistration to first local failure event, assessed for 36 months",null,{"allocation":126,"interventionModel":127,"interventionModelDescription":124,"primaryPurpose":128,"observationalModel":124,"timePerspective":124,"maskingInfo":129},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":130,"maskingDescription":124,"whoMasked":124},"NONE","FaR-RMS is an over-arching study for children and adults with newly diagnosed and relapsed rhabdomyosarcoma (RMS). It is a multi-arm, multi-stage format, involving several different trial questions. FaR-RMS is intended to be a rolling programme of research with new treatment arms being introduced dependant on emerging data and innovation. This study has multiple aims. It aims to evaluate the impact of new agent regimens in both newly diagnosed and relapsed RMS; whether changing the duration of maintenance therapy affects outcome; and whether changes to dose, extent (in metastatic disease) and timing of radiotherapy improve outcome and quality of life. In addition the study will evaluate risk stratification through the use of PAX-FOXO1 fusion gene status instead of histological subtyping and explore the use of FDG PET-CT response assessment as a prognostic biomarker for outcome following induction chemotherapy.\n\nNewly diagnosed patients should, where possible, be entered into the FaR-RMS study at the time of first diagnosis prior to receiving any chemotherapy. However, patients can enter at the point of radiotherapy or maintenance, and those with relapsed disease can enter the study even if not previously entered at initial diagnosis. Patients may be entered into more than one randomisation\u002Fregistration, dependant on patient risk group and disease status.",[133,142,148,152,156,159,164,168,172,176,180,183,187,191,197,201,205,207,212],{"label":134,"type":135,"description":136,"interventionNames":137},"Phase 1b Dose finding: VHR induction - IRIVA","EXPERIMENTAL","Irinotecan: an i.v. infusion over 1 hour on days 8,9,10,11 and 12 . For the phase 1b registration, starting dose of 20 mg\u002Fm2.\n\nIfosfamide: 3g\u002Fm2 as an i.v. infusion over 3 hours on days 1 and 2 Vincristine: 1.5 mg\u002Fm2 as an As per local practice: recommended as a short infusion (maximum dose 2mg). Administered days 1,8,15 on cycles 1-2 and on days 1 and 8 on cycles 3-9.\n\nActinomycin: 1.5 mg\u002Fm2 as an i.v. bolus injection (maximum dose 2mg) on day 1.",[138,139,140,141],"Drug: Irinotecan","Drug: Actinomycin D","Drug: Ifosfamide","Drug: Vincristine",{"label":143,"type":144,"description":145,"interventionNames":146},"CT1A: VHR induction - IVADO","ACTIVE_COMPARATOR","Ifosfamide: 3g\u002Fm2 as an i.v. infusion over 3 hours on days 1 and 2 Vincristine: 1.5 mg\u002Fm2 As per local practice: recommended as a short infusion (maximum dose 2mg). Administered days 1,8,15 on cycles 1-2 and on day 1 on cycles 3-9.\n\nActinomycin: 1.5 mg\u002Fm2 as an i.v. bolus injection (maximum dose 2mg) on day 1. Doxorubicin: 30 mg\u002Fm2 as an i.v infusion over 1 hour on days 1 and 2 on cycles 1-4",[139,147,140,141],"Drug: Doxorubicin",{"label":149,"type":135,"description":150,"interventionNames":151},"CT1A: VHR Induction IRIVA","Irinotecan: an i.v. infusion over 1 hour on days 8,9,10,11 and 12 . Phase 2 recommended dose as determined by IRIVA dose finding arm Ifosfamide: 3g\u002Fm2 as an i.v. infusion over 3 hours on days 1 and 2 Vincristine: 1.5 mg\u002Fm2 As per local practice: recommended as a short infusion (maximum dose 2mg). Administered days 1,8,15 on cycles 1-2 and on days 1 and 8 on cycles 3-9.\n\nActinomycin: 1.5 mg\u002Fm2 as an i.v. bolus injection (maximum dose 2mg) on day 1.",[138,139,140,141],{"label":153,"type":144,"description":154,"interventionNames":155},"CT1B: HR Induction IVA","Ifosfamide: 3g\u002Fm2 as an i.v. infusion over 3 hours on days 1 and 2 Vincristine: 1.5 mg\u002Fm2 As per local practice: recommended as a short infusion (maximum dose 2mg). Administered days 1,8,15 on cycles 1-2 and on day 1 on cycles 3-9.\n\nActinomycin: 1.5 mg\u002Fm2 as an i.v. bolus injection (maximum dose 2mg) on day 1.",[139,140,141],{"label":157,"type":135,"description":150,"interventionNames":158},"CT1B: HR Induction IRIVA",[138,139,140,141],{"label":160,"type":135,"description":161,"interventionNames":162},"RT1A: Preoperative Radiotherapy","To be given either 41.4 Gy or 50.4 Gy prior to surgery",[163],"Radiation: radiotherapy",{"label":165,"type":144,"description":166,"interventionNames":167},"RT1A: Post operative radiotherapy","To be given either 41.4 Gy or 50.4 Gy following surgery",[163],{"label":169,"type":135,"description":170,"interventionNames":171},"RT1B: Radiotherapy for resectable disease: dose escalated","To receive 50.4 Gy",[163],{"label":173,"type":144,"description":174,"interventionNames":175},"RT1B: Radiotherapy for resectable disease: standard dose","To receive 41.4 Gy",[163],{"label":177,"type":135,"description":178,"interventionNames":179},"RT1C: Radiotherapy for unresectable disease: dose escalated","To receive 59.4 Gy",[163],{"label":181,"type":144,"description":170,"interventionNames":182},"RT1C: Radiotherapy for unresectable disease: standard dose",[163],{"label":184,"type":135,"description":185,"interventionNames":186},"RT2: Radiotherapy to primary tumour and involved lymph nodes","Radiotherapy to the primary tumour and involved regional lymph nodes only",[163],{"label":188,"type":135,"description":189,"interventionNames":190},"RT2: Radiotherapy to all metastatic sites","Radiotherapy given to all metastatic sites",[163],{"label":192,"type":135,"description":193,"interventionNames":194},"CT2A: VHR Maintenance - VC","Vinorelbine: 25 mg\u002Fm2 i.v. or 60 mg\u002Fm2 orally on days 1,8 and 15 Cyclophosphamide 25 mg\u002Fm2 orally daily for 28 days",[195,196],"Drug: Vinorelbine","Drug: Cyclophosphamide",{"label":198,"type":199,"description":200,"interventionNames":124},"CT2A: Maintenance -Stop treatment","NO_INTERVENTION","To stop treatment at the point of randomisation",{"label":202,"type":135,"description":203,"interventionNames":204},"CT2B: HR Maintenance - VC","Vinorelbine: 25 mg\u002Fm2 i.v. on days 1,8 and 15 Cyclophosphamide 25 mg\u002Fm2 orally daily for 28 days",[195,196],{"label":206,"type":199,"description":200,"interventionNames":124},"CT2B: HR Maintenance - Stop Treatment",{"label":208,"type":144,"description":209,"interventionNames":210},"CT3: Relpased Chemotherapy - VIRT","Vincristine: 1.5 mg\u002Fm2 As per local practice: recommended as a short infusion (maximum dose 2mg) on days 1 and 8 Irinotecan: 50 mg\u002Fm2 as an i.v. infusion over 1 hour on days 1-5 Temozolomide: 125 mg\u002Fm2 (Escalate to 150mg\u002Fm2\u002Fday in Cycle 2 if no toxicity \\> grade 3) as an oral tablets prior to vincristine and irinotecan on days 1-5",[138,141,211],"Drug: Temozolomide",{"label":213,"type":135,"description":214,"interventionNames":215},"CT3: Relapsed Chemotherapy - VIRR","Vincristine: 1.5 mg\u002Fm2 As per local practice: recommended as a short infusion (maximum dose 2mg) on days 1 and 8 Irinotecan: 50 mg\u002Fm2 as an i.v. infusion over 1 hour on days 1-5 Regorafenib: Children between 6 and 24 months = 65 mg\u002Fm2, children less than 12 and\u002For less than 40kg dose = 82 mg\u002Fm2 Maximum 120 mg, Fixed dose of 120 mg for patients over 12 years of age AND ≥ 40 kg, as an oral tablets on days 8 to 21.",[138,141,216],"Drug: Regorafenib",[218,223,229,233,237,241,245,249,253,258],{"type":219,"name":220,"description":221,"armGroupLabels":222,"otherNames":124},"DRUG","Irinotecan","antineoplastic enzyme inhibitor",[149,157,213,208,134],{"type":219,"name":224,"description":225,"armGroupLabels":226,"otherNames":227},"Actinomycin D","Antineoplastic agent that is a polypeptide antibiotic",[149,143,157,153,134],[228],"Dactinomycin",{"type":219,"name":230,"description":231,"armGroupLabels":232,"otherNames":124},"Doxorubicin","An anthracycline topoisomerase inhibitor isolated from streptpmyces peucetius var. casesius",[143],{"type":219,"name":234,"description":235,"armGroupLabels":236,"otherNames":124},"Ifosfamide","chemotherapeutic agent chemically related to the nitrogen mustards and is a synthetic analog of cyclophosphamide",[149,143,157,153,134],{"type":219,"name":238,"description":239,"armGroupLabels":240,"otherNames":124},"Vincristine","anti neoplastic vinca alkaloid agent",[149,143,157,153,213,208,134],{"type":219,"name":242,"description":243,"armGroupLabels":244,"otherNames":124},"Vinorelbine","vinca alkaloid with a role as an antineoplastic agent",[192,202],{"type":219,"name":246,"description":247,"armGroupLabels":248,"otherNames":124},"Cyclophosphamide","Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent",[192,202],{"type":219,"name":250,"description":251,"armGroupLabels":252,"otherNames":124},"Temozolomide","oral antineoplastic alkylating agent",[208],{"type":254,"name":255,"description":256,"armGroupLabels":257,"otherNames":124},"RADIATION","radiotherapy","Ionising radiation",[165,160,169,173,177,181,188,184],{"type":219,"name":259,"description":260,"armGroupLabels":261,"otherNames":124},"Regorafenib","Oral multi-kinase inhibitor that targets a broad range of angiogenic, stromal and oncogenic kinases, including vascular endothelial growth factor receptors (VEFGR) 1, 2 and 3, tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (TIE2), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptors (FGFR), c-KIT, RET, RAF-1 and BRAF (wild-type and V600E mutant).",[213],[263],{"name":264,"affiliation":265,"role":266},"Meriel Jenney","Chief Investigator","PRINCIPAL_INVESTIGATOR",[268,273],{"name":269,"role":270,"phone":271,"phoneExt":124,"email":272},"Bridget Shaw","CONTACT","0121 414 2996","farrms@trials.bham.ac.uk",{"name":274,"role":270,"phone":275,"phoneExt":124,"email":272},"Emma Gray","0121 414 3799",[277,293,304,315,326,334,346,357,368,376,387,398,412,423,436,444,455,466,477,485,498,511,522,535,546,557,568,579,587,598,609,620,631,642,653,664,675,686,694,705,716,727,738,746,757,768,779,790,801,813,827,835,843,851,862,874,885,893,907,920,931,942,953,964,977,990,1001,1014,1025,1038,1049,1057,1068,1079,1092,1105,1118,1126,1139,1147,1159,1171,1179,1187,1198,1209,1221,1232,1245,1258,1269,1280,1291,1302,1313,1324,1335,1346,1362,1373,1384,1391,1402,1410,1421,1428,1439,1449,1457,1468,1479,1487,1498,1505,1516,1527,1538,1546,1554,1567,1575,1586,1597,1608,1616,1627,1638,1646],{"facility":278,"status":279,"city":280,"state":124,"zip":281,"country":282,"countryCode":283,"cosmosGeoPoint":284,"geoPoint":289,"contacts":290},"Queensland Children's Hospital","RECRUITING","Brisbane","4101","Australia","AU",{"type":285,"coordinates":286},"Point",[287,288],153.02809,-27.46794,{"lat":288,"lon":287},[291],{"name":292,"role":270,"phone":124,"phoneExt":124,"email":124},"R Walker",{"facility":294,"status":279,"city":295,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"Chris O'brien Lifehouse","Camperdown",{"type":285,"coordinates":297},[298,299],151.17642,-33.88965,{"lat":299,"lon":298},[302],{"name":303,"role":270,"phone":124,"phoneExt":124,"email":124},"Angela Hong",{"facility":305,"status":279,"city":306,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":307,"geoPoint":311,"contacts":312},"Monash Children's Hospital","Clayton",{"type":285,"coordinates":308},[309,310],145.11667,-37.91667,{"lat":310,"lon":309},[313],{"name":314,"role":270,"phone":124,"phoneExt":124,"email":124},"Paul Wood",{"facility":316,"status":279,"city":317,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":318,"geoPoint":322,"contacts":323},"Peter Maccallum Cancer Centre","Melbourne",{"type":285,"coordinates":319},[320,321],144.96332,-37.814,{"lat":321,"lon":320},[324],{"name":325,"role":270,"phone":124,"phoneExt":124,"email":124},"Jeremy Lewin",{"facility":327,"status":279,"city":317,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":328,"geoPoint":330,"contacts":331},"Royal Childrens Hospital Melbourne",{"type":285,"coordinates":329},[320,321],{"lat":321,"lon":320},[332],{"name":333,"role":270,"phone":124,"phoneExt":124,"email":124},"Marty Campbell",{"facility":335,"status":279,"city":336,"state":124,"zip":337,"country":282,"countryCode":283,"cosmosGeoPoint":338,"geoPoint":342,"contacts":343},"John Hunter Children's Hospital","New Lambton Heights","2310",{"type":285,"coordinates":339},[340,341],151.69364,-32.92466,{"lat":341,"lon":340},[344],{"name":345,"role":270,"phone":124,"phoneExt":124,"email":124},"E Hesketh",{"facility":347,"status":279,"city":348,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":349,"geoPoint":353,"contacts":354},"Perth Children's Hospital","Perth",{"type":285,"coordinates":350},[351,352],115.8614,-31.95224,{"lat":352,"lon":351},[355],{"name":356,"role":270,"phone":124,"phoneExt":124,"email":124},"Marianne Phillips",{"facility":358,"status":279,"city":359,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":360,"geoPoint":364,"contacts":365},"Sydney Children's Hospital","Sydney",{"type":285,"coordinates":361},[362,363],151.20732,-33.86785,{"lat":363,"lon":362},[366],{"name":367,"role":270,"phone":124,"phoneExt":124,"email":124},"Timothy Trahair",{"facility":369,"status":279,"city":359,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":370,"geoPoint":372,"contacts":373},"The Childrens Hospital At Westmead",{"type":285,"coordinates":371},[362,363],{"lat":363,"lon":362},[374],{"name":375,"role":270,"phone":124,"phoneExt":124,"email":124},"Jessica Ryan",{"facility":377,"status":279,"city":378,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"Westmead Hospital","Westmead",{"type":285,"coordinates":380},[381,382],150.98768,-33.80383,{"lat":382,"lon":381},[385],{"name":386,"role":270,"phone":124,"phoneExt":124,"email":124},"Jennifer Chard",{"facility":388,"status":279,"city":389,"state":124,"zip":124,"country":282,"countryCode":283,"cosmosGeoPoint":390,"geoPoint":394,"contacts":395},"Princess Alexandra Hospital","Woolloongabba",{"type":285,"coordinates":391},[392,393],153.03655,-27.48855,{"lat":393,"lon":392},[396],{"name":397,"role":270,"phone":124,"phoneExt":124,"email":124},"Rick Walker",{"facility":399,"status":279,"city":400,"state":124,"zip":124,"country":401,"countryCode":402,"cosmosGeoPoint":403,"geoPoint":407,"contacts":408},"Kepler University Clinic Linz","Linz","Austria","AT",{"type":285,"coordinates":404},[405,406],14.28611,48.30639,{"lat":406,"lon":405},[409,411],{"name":410,"role":270,"phone":124,"phoneExt":124,"email":124},"B Aistleitner",{"name":410,"role":266,"phone":124,"phoneExt":124,"email":124},{"facility":413,"status":279,"city":414,"state":124,"zip":124,"country":401,"countryCode":402,"cosmosGeoPoint":415,"geoPoint":419,"contacts":420},"St Anna Childrens Hospital","Vienna",{"type":285,"coordinates":416},[417,418],16.37208,48.20849,{"lat":418,"lon":417},[421],{"name":422,"role":270,"phone":124,"phoneExt":124,"email":124},"Ruth Ladenstein",{"facility":424,"status":279,"city":425,"state":124,"zip":124,"country":426,"countryCode":427,"cosmosGeoPoint":428,"geoPoint":432,"contacts":433},"Cliniques Universitaires Saint 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Blanco",{"facility":1628,"status":279,"city":1629,"state":124,"zip":124,"country":1351,"countryCode":1352,"cosmosGeoPoint":1630,"geoPoint":1634,"contacts":1635},"Sheffield Children's Hospital","Sheffield",{"type":285,"coordinates":1631},[1632,1633],-1.4659,53.38297,{"lat":1633,"lon":1632},[1636],{"name":1637,"role":270,"phone":124,"phoneExt":124,"email":124},"Anna Jenkins",{"facility":1639,"status":895,"city":1629,"state":124,"zip":124,"country":1351,"countryCode":1352,"cosmosGeoPoint":1640,"geoPoint":1642,"contacts":1643},"Weston Park Hospital",{"type":285,"coordinates":1641},[1632,1633],{"lat":1633,"lon":1632},[1644],{"name":1645,"role":270,"phone":124,"phoneExt":124,"email":124},"Robin Young",{"facility":1647,"status":279,"city":1648,"state":124,"zip":124,"country":1351,"countryCode":1352,"cosmosGeoPoint":1649,"geoPoint":1653,"contacts":1654},"Southampton General Hospital","Southampton",{"type":285,"coordinates":1650},[1651,1652],-1.40428,50.90395,{"lat":1652,"lon":1651},[1655],{"name":1656,"role":270,"phone":124,"phoneExt":124,"email":124},"Jessica Bate",{"type":1658,"investigatorFullName":124,"investigatorTitle":124,"investigatorAffiliation":124,"oldNameTitle":124,"oldOrganization":124},"SPONSOR","100410545",false,"NCT04625907","FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma","FaR-RMS","Inclusion Criteria for study entry - Mandatory at first point of study entry\n\n1. Histologically confirmed diagnosis of RMS (except pleomorphic RMS)\n2. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nPhase 1b Dose Finding - IRIVA Inclusion\n\n1. Entered in to the FaR-RMS study at diagnosis\n2. Very High Risk disease\n3. Age \\>12 months and ≤25 years\n4. No prior treatment for RMS other than surgery\n5. Medically fit to receive treatment\n6. Adequate hepatic function:\n\n   1. Total bilirubin ≤ 1.5 times upper limit of normal (ULN) for age, unless the patient is known to have Gilbert's syndrome\n   2. ALT or AST \\\u003C 2.5 X ULN for age\n7. Absolute neutrophil count ≥1.0x 109\u002FL\n8. Platelets ≥ 80 x 109\u002FL\n9. Adequate renal function: estimated or measured creatinine clearance ≥60 ml\u002Fmin\u002F1.73 m2\n10. Documented negative pregnancy test for female patients of childbearing potential\n11. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n12. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nExclusion\n\n1. Weight \\\u003C10kg\n2. Active \\> grade 2 diarrhoea\n3. Prior allo- or autologous Stem Cell Transplant\n4. Uncontrolled inter-current illness or active infection\n5. Pre-existing medical condition precluding treatment\n6. Urinary outflow obstruction that cannot be relieved prior to starting treatment\n7. Active inflammation of the urinary bladder (cystitis)\n8. Known hypersensitivity to any of the treatments or excipients\n9. Second malignancy\n10. Pregnant or breastfeeding women\n\nFrontline chemotherapy randomisation Very High Risk - CT1a Inclusion\n\n1. Entered in to the FaR-RMS study at diagnosis\n2. Very High Risk disease\n3. Age ≥ 6 months\n4. Available for randomisation ≤60 days after diagnostic biopsy\u002Fsurgery\n5. No prior treatment for RMS other than surgery\n6. Medically fit to receive treatment\n7. Adequate hepatic function :\n\n   a. Total bilirubin ≤ 1.5 times upper limit of normal (ULN) for age, unless the patient is known to have Gilbert's syndrome\n8. Absolute neutrophil count ≥1.0x 109\u002FL (except in patients with documented bone marrow disease)\n9. Platelets ≥ 80 x 109\u002FL (except in patients with documented bone marrow disease)\n10. Fractional Shortening ≥ 28%\n11. Documented negative pregnancy test for female patients of childbearing potential\n12. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n13. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nExclusion\n\n1. Active \\> grade 2 diarrhoea\n2. Prior allo- or autologous Stem Cell Transplant\n3. Uncontrolled inter-current illness or active infection\n4. Pre-existing medical condition precluding treatment\n5. Urinary outflow obstruction that cannot be relieved prior to starting treatment\n6. Active inflammation of the urinary bladder (cystitis)\n7. Known hypersensitivity to any of the treatments or excipients\n8. Second malignancy\n9. Pregnant or breastfeeding women\n\nFrontline chemotherapy randomisation High Risk - CT1b Inclusion\n\n1. Entered in to the FaR-RMS study at diagnosis\n2. High Risk disease\n3. Age ≥ 6 months\n4. Available for randomisation ≤60 days after diagnostic biopsy\u002Fsurgery\n5. No prior treatment for RMS other than surgery\n6. Medically fit to receive treatment\n7. Adequate hepatic function :\n\n   a. Total bilirubin ≤ 1.5 times upper limit of normal (ULN) for age, except if the patient is known to have Gilbert's syndrome\n8. Absolute neutrophil count ≥1.0x 109\u002FL\n9. Platelets ≥ 80 x 109\u002FL\n10. Documented negative pregnancy test for female patients of childbearing potential\n11. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n12. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nExclusion\n\n1. Active \\> grade 2 diarrhoea\n2. Prior allo- or autologous Stem Cell Transplant\n3. Uncontrolled inter-current illness or active infection\n4. Pre-existing medical condition precluding treatment\n5. Urinary outflow obstruction that cannot be relieved prior to starting treatment\n6. Active inflammation of the urinary bladder (cystitis)\n7. Known hypersensitivity to any of the treatments or excipients\n8. Second malignancy\n9. Pregnant or breastfeeding women\n\nFrontline Radiotherapy Note: eligible patients may enter multiple radiotherapy randomisations.\n\nRadiotherapy Inclusion - for all radiotherapy randomisations\n\n1. Entered in to the FaR-RMS study (at diagnosis or prior to radiotherapy randomisation)\n2. Very High Risk, High Risk and Standard Risk disease\n3. ≥ 2 years of age\n4. Receiving frontline induction treatment as part of the FaR-RMS trial or with a IVA\u002FIVADo based chemotherapy regimen patients for whom. Note that patients for whom ifosfamide has been replaced with cyclophosphamide will be eligible\n5. Patient assessed as medically fit to receive the radiotherapy\n6. Documented negative pregnancy test for female patients of childbearing potential\n7. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n8. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nRadiotherapy Exclusion - for all radiotherapy randomisations\n\n1. Prior allo- or autologous Stem Cell Transplant\n2. Second malignancy\n3. Pregnant or breastfeeding women\n4. Receiving radiotherapy as brachytherapy\n\nRT1a Specific Inclusion\n\n1. Primary tumour deemed resectable (predicted R0\u002F R1 resection feasible) after 3 cycles of induction chemotherapy (6 cycles for metastatic disease)\n2. Adjuvant radiotherapy required in addition to surgical resection (local decision).\n3. Available for randomisation after cycle 3 and prior to the start of cycle 6 of induction chemotherapy for localised disease, or after cycle 6 and prior to the start of cycle 9 for metastatic disease\n\nRT1b Specific Inclusion\n\n1. Primary tumour deemed resectable (predicted R0\u002FR1 resection) after 3 cycles of induction chemotherapy (6 cycles for metastatic disease).\n2. Adjuvant radiotherapy required in addition to surgical resection (local decision)\n3. Higher Local Failure Risk (HLFR) based on presence of either of the following criteria:\n\n   1. Unfavourable site\n   2. Age ≥ 18yrs\n4. Available for randomisation after cycle 3 and prior to the start of cycle 6 of induction chemotherapy for localised disease, or after cycle 6 and prior to the start of cycle 9 for metastatic disease\n\nRT1c Specific Inclusion\n\n1. Primary radiotherapy indicated (local decision)\n2. Higher Local Failure Risk (HLFR) based on either of the following criteria:\n\n   1. Unfavourable site\n   2. Age ≥ 18yrs\n3. Available for randomisation after cycle 3 and prior to the start of cycle 6 of induction chemotherapy for localised disease, or after cycle 6 and prior to the start of cycle 9 for metastatic disease\n\nRT2\n\n1. Available for randomisation after cycle 6 and before the start of cycle 9 of induction chemotherapy.\n2. Unfavourable metastatic disease, defined as Modified Oberlin Prognostic Score 2-4\n\n   * Note: Definition of metastatic lesions for RT2 eligibility\n\nModified Oberlin Prognostic Score (1 point for each adverse factor):\n\n* Age ≥10y\n* Extremity, Other, Unidentified Primary Site\n* Bone and\u002F or Bone Marrow involvement\n* ≥3 metastatic sites\n\nUnfavourable metastatic disease: 2- 4 adverse factors Favourable metastatic disease: 0-1 adverse factors\n\nMaintenance chemotherapy (Very High Risk) - CT2a Inclusion Randomisation must take place during the 12th cycle of maintenance chemotherapy.\n\n1. Entered in to the FaR-RMS study (at diagnosis or at any subsequent time point)\n2. Very High Risk disease\n3. Received frontline induction chemotherapy as part of the FaR-RMS trial or with a IVA\u002FIVADo based chemotherapy regimen\n\n   a. Patients for whom ifosfamide has been replaced with cyclophosphamide will be eligible\n4. Completed 11 cycles of VnC maintenance treatment (either oral or IV regimens)\n5. No evidence of progressive disease\n6. Absence of severe vincristine neuropathy - i.e requiring discontinuation of vincristine treatment)\n7. Medically fit to continue to receive treatment\n8. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n9. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nExclusion\n\n1. Prior allo- or autologous Stem Cell Transplant\n2. Uncontrolled intercurrent illness or active infection\n3. Urinary outflow obstruction that cannot be relieved prior to starting treatment\n4. Active inflammation of the urinary bladder (cystitis)\n5. Second malignancy\n6. Pregnant or breastfeeding women\n\nMaintenance chemotherapy (High Risk) - CT2b Randomisation must take place during the 6th cycle of maintenance chemotherapy. Inclusion\n\n1. Entered in to the FaR-RMS study (at diagnosis or at any subsequent time point)\n2. High Risk disease\n3. Received frontline induction chemotherapy as part of the FaR-RMS trial or with a IVA based chemotherapy regimen. Note that patients for whom ifosfamide has been replaced with cyclophosphamide will be eligible\n4. Completed 5 cycles of VnC maintenance treatment\n5. No evidence of progressive disease\n6. Absence of severe vincristine neuropathy i.e. requiring discontinuation of vincristine treatment\n7. Medically fit to continue to receive treatment\n8. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n9. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nExclusion\n\n1. Prior allo- or autologous Stem Cell Transplant\n2. Uncontrolled inter current illness or active infection\n3. Urinary outflow obstruction that cannot be relieved prior to starting treatment\n4. Active inflammation of the urinary bladder (cystitis)\n5. Second malignancy\n6. Pregnant or breastfeeding women\n\nCT3 Relapsed Chemotherapy\n\nInclusion:\n\n1. Entered in to the FaR-RMS study (at diagnosis or at any subsequent time point)\n2. First or subsequent relapse of histologically verified RMS\n3. Age ≥ 6 months\n4. Measurable or evaluable disease\n5. No cytotoxic chemotherapy or other investigational medicinal product (IMP) within previous three weeks: within two weeks for vinorelbine and cyclophosphamide maintenance chemotherapy\n6. Medically fit to receive trial treatment\n7. Documented negative pregnancy test for female patients of childbearing potential within 7 days of planned randomisation\n8. Patient agrees to use contraception during therapy and for 12 months after last trial treatment (females) or 6 months after last trial treatment (males), where patient is sexually active\n9. Written informed consent from the patient and\u002For the parent\u002Flegal guardian\n\nExclusion:\n\n1. Progression during frontline therapy without previous response (=Refractory to first line treatment)\n2. Prior regorafenib or temozolomide\n3. Active \\> grade 1 diarrhoea\n4. ALT or AST \\>3.0 x upper limit normal (ULN)\n5. Bilirubin, Total \\>1.5 x ULN; total bilirubin is allowed up to 3 x ULN if Gilbert's syndrome is documented\n6. Patients with unstable angina or new onset angina (within 3 months of planned date of randomisation), recent myocardial infarction (within 6 months of randomisation) and those with cardiac failure New York Heart Association (NYHA) Classification 2 or higher Cardiac abnormalities such as congestive heart failure (Modified Ross Heart Failure Classification for Children = class 2) and cardiac arrhythmias requiring antiarrhythmic therapy (beta blockers or digoxin are permitted)\n7. Uncontrolled hypertension \\> 95th centile for age and gender\n8. Prior allo- or autologous Stem Cell Transplant\n9. Uncontrolled inter-current illness or active infection\n10. Pre-existing medical condition precluding treatment\n11. Known hypersensitivity to any of the treatments or excipients\n12. Second malignancy\n13. Pregnant or breastfeeding women","ALL",{"count":1667,"type":1668},1672,"ESTIMATED","INTERVENTIONAL",[1671,1672],"PHASE1","PHASE2","FaR-RMS is an over-arching study for children and adults with newly diagnosed and relapsed rhabdomyosarcoma (RMS)",[1675],"Rhabdomyosarcoma","2024-05-22",{"date":1678,"type":1679},"2024-05-23","ACTUAL",{"date":1681,"type":1679},"2020-09-17",{"date":1683,"type":1668},"2030-06",{"name":5,"class":6},128]