This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will be delivered using a range of stimulation parameters during psychological and physiological monitoring. Individualized optimal targets will be selected using structural MRI and diffusion tractography. Brain target engagement will be evaluated using functional MRI.
Age 18-65, any gender.
Primary diagnosis of DMS-5 major depressive disorder (MINI).
Current moderate-to-severe depressive episode, without psychotic features, lasting at least 2 months (MINI).
Self-rated 16-item Quick Inventory of Depressive Symptomatology (QIDS) total score > 10.
History of serious brain injury or other neurologic disorder.
Poorly managed general medical condition.
Pregnant or breast feeding.
Implanted device in the head or neck.
Brian Mickey
Lead sponsor
University of Utah
Sponsor institution
National Institute of Mental Health (NIMH)
Collaborator