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University","Zhujiang",{"type":74,"coordinates":569},[570,571],114.70443,27.27685,{"lat":571,"lon":570},[574,576],{"name":575,"role":63,"phone":37,"phoneExt":37,"email":37},"Jian Zhang",{"name":575,"role":60,"phone":37,"phoneExt":37,"email":37},{"type":578,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100509823",false,"NCT05918445","PM8002 in the Treatment of Patients With Advanced Solid Tumors","Phase Ib\u002FIIa Safety and Efficacy of PM8002, a Bispecific Antibody Targeting PD-L1 and VEGF-A, as a Monotherapy in Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n1. Voluntary participation in clinical study; fully understand the study and sign informed consent voluntarily; willing to follow and able to complete all test procedures;\n2. Male or female aged 18 to 75 years;\n3. Patients with malignant tumor confirmed by histology or cytology;\n4. The toxicity of previous anti-tumor therapy has not been alleviated；\n5. Adequate organ function；\n6. ECOG score was 0-1;\n7. Expected survival \\>=12 weeks;\n8. According to RECIST 1.1 criteria, at least 1 measurable lesion that has not been previously treated locally.\n\nExclusion Criteria:\n\n1. History of severe allergic disease, severe allergy to drugs or known allergy to any component of the drug in this study;\n2. Evidence of major coagulopathy or other obvious risk of bleeding;\n3. Patients are experiencing a clear interstitial lung disease or non-infectious pneumonia, unless it is caused by local radiotherapy;\n4. Patients with uncontrolled brain metastases should be excluded from this clinical trial;\n5. Patients ever experienced other active malignant tumors within 5 years prior to the study treatment;\n6. Prior allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation;\n7. Known history of alcohol abuse, psychotropic drug abuse or drug abuse;\n8. Syphilis antibody positive;\n9. Patients with active tuberculosis (TB) are excluded;\n10. Pregnant or lactating women;\n11. Other conditions lead to inappropriate to participate in this study as judged by the investigator.","ALL","18 Years","75 Years",{"count":589,"type":590},380,"ESTIMATED","INTERVENTIONAL",[593,594],"PHASE1","PHASE2","This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of PM8002, a PD-L1\u002FVEGF bispecific antibody, as a single agent in adult subjects with advanced solid tumors.",[597],"Malignant Neoplasm","2024-12-03",{"date":600,"type":601},"2024-12-05","ACTUAL",{"date":603,"type":601},"2021-03-09",{"date":605,"type":590},"2025-11-30",{"name":5,"class":6},48]