Health Trials

About this trial

This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effects commonly seen in medications, such as sleepiness and addiction. This study uses rTMS to manage chronic headaches to improve post-concussion symptoms and reduce the economic burden due to delayed recovery. This project aims to better identify biomarkers for diagnosis and prognosis and maximize recovery from mTBI.

Eligibility criteria

Qualifiers

18 - 55 years old

mTBI with loss of consciousness for less than 30 min, initial Glasgow Coma Scale between 13 and 15, or post-traumatic amnesia for ≤ 24 hours

diagnosis of persistent post-traumatic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria

headache develops within 7 days after head trauma

Disqualifiers

history of chronic headache diagnoses such as migraine, tension, or cluster headaches prior to the incidence of mTBI

history of other neurologic conditions with medications affecting the central nervous system

contraindications of receiving TMS (e.g., a history of epileptic seizure and having implants like a cardiac pacemaker or intracerebral vascular clip

Trial design

Treatments tested in this trial

  • Repetitive Transcranial Magnetic Stimulation
  • Sham Repetitive Transcranial Magnetic Stimulation

Treatment groups

60 Participants
are divided into 4 treatment groups

Locations

1
SUNY Upstate Medical University13210, SyracuseNew York, United States

Sponsors and collaborators

State University of New York - Upstate Medical University

Lead sponsor

Source ClinicalTrials.gov