[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609607":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":59,"collaborators":20,"id":61,"slug":20,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":20,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":20,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Minicircle","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Schedule of Administration and Sample Selection","EXPERIMENTAL","This arm includes cognitive and health battery at multiple intervals pre- and post-administration of Klotho",[13],"Genetic: Injectable Plasmid Klotho Gene Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","Injectable Plasmid Klotho Gene Therapy","Injection of plasmid-delivered Klotho gene therapy",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Mac Davis","CONTACT","512-630-0882","mac@minicircle.io",[28,43],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Apeiron Center","RECRUITING","Austin","Texas","78701","United States",{"type":36,"coordinates":37},"Point",[38,39],-97.74306,30.26715,{"lat":39,"lon":38},[42],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"facility":44,"status":45,"city":46,"state":47,"zip":20,"country":48,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"GARM Clinic","NOT_YET_RECRUITING","Roatán","Bay Islands","Honduras",{"type":36,"coordinates":50},[51,52],-86.53605,16.3229,{"lat":52,"lon":51},[55],{"name":56,"role":24,"phone":57,"phoneExt":20,"email":58},"Mayra Hoch","+504 2408-3544","mayra@garmclinic.com",{"type":60,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100609607",false,"NCT07216781","Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans","Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study","Inclusion Criteria:\n\n* Participant is open to morphological change\n* If female, participant agrees to maintain contraception\n* If female, participant agrees to take a pregnancy test\n* If female, participant agrees to a pregnancy waiver\n\nExclusion Criteria:\n\n* Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study\n* History of cancer diagnosis\n* Preexisting medical issues that may be exacerbated by the treatment\n* Has received any gene therapy within the past 12 months\n* Unwilling or unable to provide written informed consent",true,"ALL","23 Years","90 Years",{"count":72,"type":73},24,"ESTIMATED","INTERVENTIONAL",[76],"PHASE1","The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.",[79],"Healthy Adults",[81,82,83],"Klotho","plasmid","gene therapy","2026-02-15",{"date":86,"type":87},"2026-02-17","ACTUAL",{"date":89,"type":87},"2025-10-06",{"date":91,"type":73},"2026-08",{"name":5,"class":6},2]