About this trial

This study is a Phase 1 multicenter study with a Dose Escalation and Dose Expansion evaluating safety and efficacy of MT-601 administration to patients with Relapsed or Refractory Lymphoma. The starting dose administered is 200 x 10\^6 cells (flat dosing).

Eligibility criteria

Qualifiers

All applicable inclusion and

Disqualifiers

Participant must be ≥ 18 years of age and capable of giving signed informed consent (ICF), which includes compliance with the requirements and restrictions listed in the ICF and in the protocol, at the time of signing the ICF.

Cytologically or histologically confirmed diagnosis of NHL, HL or CLL based on the 2022 World Health Organization (WHO) criteria for hematolymphoid neoplasms

LBCL including diffuse large B cell lymphoma, primary mediastinal B cell lymphoma (PMBCL), high grade B cell lymphoma (HGBL), T cell rich B cell lymphoma and transformed indolent lymphoma (transformed iNHL)

FL

Trial design

Treatments tested in this trial

  • MT-601

Treatment groups

79 Participants
are divided into 1 treatment group

Locations

7
California
City of Hope91010, Duarte United States
Colorado
University of Colorado80045, Aurora United States
Colorado Blood Cancer Institute (Sarah Cannon)80218, Denver United States
Kansas
University of Kansas Medical Center66160, Kansas City United States

Sponsors and collaborators

Marker Therapeutics, Inc.

Lead sponsor