A multicenter, open, single arm dose escalation and dose expansion phase I study to evaluate the safety, tolerability, and efficacy of SCG142 TCR-T cells in Subjects with advanced HPV associated carcinomas.
Greater than or equal to 18 years of age
HPV associated carcinomas
Patients must have at least one measurable lesion defined by RECIST 1.1
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Active or uncontrollable infections or other active major medical illnesses of the cardiovascular, respiratory.
Patients with active autoimmune diseases.
Patient has a known active Hepatitis B or Hepatitis C.
Other severe medical conditions that may limit subject's participation in this trial.
The Affiliated Hospital of Qingdao University
Lead sponsor