[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626904":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":38,"centralContacts":42,"locations":52,"responsibleParty":515,"collaborators":33,"id":517,"slug":33,"hasResults":518,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":33,"eligibilityCriteria":522,"healthyVolunteers":518,"sex":523,"minAge":524,"maxAge":33,"enrollmentInfo":525,"targetDuration":33,"studyType":528,"phases":529,"briefSummary":531,"conditions":532,"keywords":534,"overallStatus":264,"whyStopped":33,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":546,"locationsCount":547},{"fullName":5,"class":6},"Incyte Corporation","INDUSTRY",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1a: Dose Escalation","EXPERIMENTAL","INCA036978 will be administered at a protocol defined starting regimen as monotherapy to identify the MTD and\u002For RDE(s).",[13],"Drug: INCA036978",{"label":15,"type":10,"description":16,"interventionNames":17},"Part 1b: Dose Escalation","INCA036978 will be administered at a protocol defined starting regimen in combination with a standard disease-directed therapy to identify the MTD and\u002For RDE(s).",[13,18],"Drug: Standard disease-directed therapy",{"label":20,"type":10,"description":21,"interventionNames":22},"Part 2a: Dose Expansion","INCA036978 will be administered as monotherapy at the RDE(s) identified during Part 1",[13],{"label":24,"type":10,"description":25,"interventionNames":26},"Part 2b: Dose Expansion","INCA036978 will be administered in combination with a standard disease-directed therapy at the RDE(s) identified during Part 1.",[13,18],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","INCA036978","INCA036978 will be administered at protocol defined dose.",[9,15,20,24],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Standard disease-directed therapy","A standard disease-directed therapy will be administered according to Prescribing Information\u002FSmPC.",[15,24],[39],{"name":40,"affiliation":5,"role":41},"Incyte Medical Monitor","STUDY_DIRECTOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":33,"email":47},"Incyte Corporation Call Center (US)","CONTACT","1.855.463.3463","medinfo@incyte.com",{"name":49,"role":45,"phone":50,"phoneExt":33,"email":51},"Incyte Corporation Call Center (ex-US)","+800 00027423","eumedinfo@incyte.com",[53,66,76,85,91,101,111,120,130,140,150,160,169,175,185,194,203,213,222,232,242,252,262,274,283,293,303,313,323,332,343,353,362,371,381,390,399,408,418,427,436,445,450,459,469,478,487,497,506],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":33},"University of Alabama At Birmingham","NOT_YET_RECRUITING","Birmingham","Alabama","35233","United States",{"type":61,"coordinates":62},"Point",[63,64],-86.80249,33.52066,{"lat":64,"lon":63},{"facility":67,"status":55,"city":68,"state":69,"zip":70,"country":59,"cosmosGeoPoint":71,"geoPoint":75,"contacts":33},"City of Hope-Lennar Foundation Cancer Center","Irvine","California","92618",{"type":61,"coordinates":72},[73,74],-117.82311,33.66946,{"lat":74,"lon":73},{"facility":77,"status":55,"city":78,"state":69,"zip":79,"country":59,"cosmosGeoPoint":80,"geoPoint":84,"contacts":33},"Usc Norris Comprehensive Cancer Center","Los Angeles","90033",{"type":61,"coordinates":81},[82,83],-118.24368,34.05223,{"lat":83,"lon":82},{"facility":86,"status":55,"city":78,"state":69,"zip":87,"country":59,"cosmosGeoPoint":88,"geoPoint":90,"contacts":33},"UCLA Medical Hematology & Oncology","90095",{"type":61,"coordinates":89},[82,83],{"lat":83,"lon":82},{"facility":92,"status":55,"city":93,"state":94,"zip":95,"country":59,"cosmosGeoPoint":96,"geoPoint":100,"contacts":33},"Yale Cancer Center","New Haven","Connecticut","06510",{"type":61,"coordinates":97},[98,99],-72.92816,41.30815,{"lat":99,"lon":98},{"facility":102,"status":55,"city":103,"state":104,"zip":105,"country":59,"cosmosGeoPoint":106,"geoPoint":110,"contacts":33},"University of Miami","Miami","Florida","33136",{"type":61,"coordinates":107},[108,109],-80.19366,25.77427,{"lat":109,"lon":108},{"facility":112,"status":55,"city":113,"state":104,"zip":114,"country":59,"cosmosGeoPoint":115,"geoPoint":119,"contacts":33},"Moffitt Cancer Center","Tampa","33612",{"type":61,"coordinates":116},[117,118],-82.45843,27.94752,{"lat":118,"lon":117},{"facility":121,"status":55,"city":122,"state":123,"zip":124,"country":59,"cosmosGeoPoint":125,"geoPoint":129,"contacts":33},"Winship Cancer Institute of Emory University","Atlanta","Georgia","30322",{"type":61,"coordinates":126},[127,128],-84.38798,33.749,{"lat":128,"lon":127},{"facility":131,"status":55,"city":132,"state":133,"zip":134,"country":59,"cosmosGeoPoint":135,"geoPoint":139,"contacts":33},"John Hopkins Hospital","Baltimore","Maryland","21287",{"type":61,"coordinates":136},[137,138],-76.61219,39.29038,{"lat":138,"lon":137},{"facility":141,"status":55,"city":142,"state":143,"zip":144,"country":59,"cosmosGeoPoint":145,"geoPoint":149,"contacts":33},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":61,"coordinates":146},[147,148],-71.05977,42.35843,{"lat":148,"lon":147},{"facility":151,"status":55,"city":152,"state":153,"zip":154,"country":59,"cosmosGeoPoint":155,"geoPoint":159,"contacts":33},"Washington University School of Medicine","St Louis","Missouri","63108",{"type":61,"coordinates":156},[157,158],-90.19789,38.62727,{"lat":158,"lon":157},{"facility":161,"status":55,"city":162,"state":162,"zip":163,"country":59,"cosmosGeoPoint":164,"geoPoint":168,"contacts":33},"Mount Sinai School of Medicine","New York","10029",{"type":61,"coordinates":165},[166,167],-74.00597,40.71427,{"lat":167,"lon":166},{"facility":170,"status":55,"city":162,"state":162,"zip":171,"country":59,"cosmosGeoPoint":172,"geoPoint":174,"contacts":33},"Weill Cornell Medicine","10065",{"type":61,"coordinates":173},[166,167],{"lat":167,"lon":166},{"facility":176,"status":55,"city":177,"state":178,"zip":179,"country":59,"cosmosGeoPoint":180,"geoPoint":184,"contacts":33},"University of North Carolina At Chapel Hill","Chapel Hill","North Carolina","27514",{"type":61,"coordinates":181},[182,183],-79.05584,35.9132,{"lat":183,"lon":182},{"facility":186,"status":55,"city":187,"state":178,"zip":188,"country":59,"cosmosGeoPoint":189,"geoPoint":193,"contacts":33},"Levine Cancer Institute","Charlotte","28204",{"type":61,"coordinates":190},[191,192],-80.84313,35.22709,{"lat":192,"lon":191},{"facility":195,"status":55,"city":196,"state":178,"zip":197,"country":59,"cosmosGeoPoint":198,"geoPoint":202,"contacts":33},"Duke University Medical Center, Department of Hematologic Malignancies and Cellular Therapy","Durham","27705",{"type":61,"coordinates":199},[200,201],-78.89862,35.99403,{"lat":201,"lon":200},{"facility":204,"status":55,"city":205,"state":206,"zip":207,"country":59,"cosmosGeoPoint":208,"geoPoint":212,"contacts":33},"Cleveland Clinic","Cleveland","Ohio","44195",{"type":61,"coordinates":209},[210,211],-81.69541,41.4995,{"lat":211,"lon":210},{"facility":214,"status":55,"city":215,"state":206,"zip":216,"country":59,"cosmosGeoPoint":217,"geoPoint":221,"contacts":33},"Ohio State University","Columbus","43210",{"type":61,"coordinates":218},[219,220],-82.99879,39.96118,{"lat":220,"lon":219},{"facility":223,"status":55,"city":224,"state":225,"zip":226,"country":59,"cosmosGeoPoint":227,"geoPoint":231,"contacts":33},"Tristar Bmt\u002FTcto","Nashville","Tennessee","37203",{"type":61,"coordinates":228},[229,230],-86.78444,36.16589,{"lat":230,"lon":229},{"facility":233,"status":55,"city":234,"state":235,"zip":236,"country":59,"cosmosGeoPoint":237,"geoPoint":241,"contacts":33},"University of Texas M. D. Anderson Cancer Center","Houston","Texas","77030",{"type":61,"coordinates":238},[239,240],-95.36327,29.76328,{"lat":240,"lon":239},{"facility":243,"status":55,"city":244,"state":245,"zip":246,"country":59,"cosmosGeoPoint":247,"geoPoint":251,"contacts":33},"Huntsman Cancer Institute","Salt Lake City","Utah","84112",{"type":61,"coordinates":248},[249,250],-111.89105,40.76078,{"lat":250,"lon":249},{"facility":253,"status":55,"city":254,"state":255,"zip":256,"country":59,"cosmosGeoPoint":257,"geoPoint":261,"contacts":33},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":61,"coordinates":258},[259,260],-87.90647,43.0389,{"lat":260,"lon":259},{"facility":263,"status":264,"city":265,"state":266,"zip":267,"country":268,"cosmosGeoPoint":269,"geoPoint":273,"contacts":33},"Concord General Repatriation Hospital","RECRUITING","Concord","New South Wales","02139","Australia",{"type":61,"coordinates":270},[271,272],151.10381,-33.84722,{"lat":272,"lon":271},{"facility":275,"status":55,"city":276,"state":266,"zip":277,"country":268,"cosmosGeoPoint":278,"geoPoint":282,"contacts":33},"Royal North Shore Hospital","St Leonards","02065",{"type":61,"coordinates":279},[280,281],151.19836,-33.82344,{"lat":281,"lon":280},{"facility":284,"status":264,"city":285,"state":286,"zip":287,"country":268,"cosmosGeoPoint":288,"geoPoint":292,"contacts":33},"Icon Cancer Centre","Auchenflower","Queensland","04066",{"type":61,"coordinates":289},[290,291],152.99213,-27.47443,{"lat":291,"lon":290},{"facility":294,"status":264,"city":295,"state":296,"zip":297,"country":268,"cosmosGeoPoint":298,"geoPoint":302,"contacts":33},"Epworth Health Care","East Melbourne","Victoria","03002",{"type":61,"coordinates":299},[300,301],144.9879,-37.81667,{"lat":301,"lon":300},{"facility":304,"status":264,"city":305,"state":306,"zip":307,"country":268,"cosmosGeoPoint":308,"geoPoint":312,"contacts":33},"Linear Clinical Research","Nedlands","Western Australia","06009",{"type":61,"coordinates":309},[310,311],115.8073,-31.98184,{"lat":311,"lon":310},{"facility":314,"status":55,"city":315,"state":33,"zip":316,"country":317,"cosmosGeoPoint":318,"geoPoint":322,"contacts":33},"Centre Hospitalier Universitaire (Chu) de Liege","Liège","04000","Belgium",{"type":61,"coordinates":319},[320,321],5.56749,50.63373,{"lat":321,"lon":320},{"facility":324,"status":55,"city":325,"state":33,"zip":326,"country":317,"cosmosGeoPoint":327,"geoPoint":331,"contacts":33},"AZ DELTA","Roeselare","08800",{"type":61,"coordinates":328},[329,330],3.12269,50.94653,{"lat":330,"lon":329},{"facility":333,"status":55,"city":334,"state":335,"zip":336,"country":337,"cosmosGeoPoint":338,"geoPoint":342,"contacts":33},"McGill University Jewish General Hospital","Montreal","Quebec","H3T 1E2","Canada",{"type":61,"coordinates":339},[340,341],-73.58781,45.50884,{"lat":341,"lon":340},{"facility":344,"status":55,"city":345,"state":33,"zip":346,"country":347,"cosmosGeoPoint":348,"geoPoint":352,"contacts":33},"Institut Bergonie","Bordeaux","33076","France",{"type":61,"coordinates":349},[350,351],-0.58046,44.84124,{"lat":351,"lon":350},{"facility":354,"status":55,"city":355,"state":33,"zip":356,"country":347,"cosmosGeoPoint":357,"geoPoint":361,"contacts":33},"Hospital Saint Louis","Paris","75010",{"type":61,"coordinates":358},[359,360],2.3488,48.85341,{"lat":360,"lon":359},{"facility":363,"status":55,"city":364,"state":33,"zip":365,"country":347,"cosmosGeoPoint":366,"geoPoint":370,"contacts":33},"Institut Gustave Roussy","Villejuif","94805",{"type":61,"coordinates":367},[368,369],2.35992,48.7939,{"lat":369,"lon":368},{"facility":372,"status":55,"city":373,"state":33,"zip":374,"country":375,"cosmosGeoPoint":376,"geoPoint":380,"contacts":33},"University Medical Center Rwth Aachen","Aachen","D-52074","Germany",{"type":61,"coordinates":377},[378,379],6.08342,50.77664,{"lat":379,"lon":378},{"facility":382,"status":55,"city":383,"state":33,"zip":384,"country":375,"cosmosGeoPoint":385,"geoPoint":389,"contacts":33},"Charite Universitaetsmedizin Berlin - Campus Charite Mitte","Berlin","10117",{"type":61,"coordinates":386},[387,388],13.41053,52.52437,{"lat":388,"lon":387},{"facility":391,"status":55,"city":392,"state":33,"zip":393,"country":375,"cosmosGeoPoint":394,"geoPoint":398,"contacts":33},"Universitatklinikum Freiburg","Freiburg im Breisgau","79106",{"type":61,"coordinates":395},[396,397],7.85222,47.9959,{"lat":397,"lon":396},{"facility":400,"status":55,"city":401,"state":33,"zip":402,"country":375,"cosmosGeoPoint":403,"geoPoint":407,"contacts":33},"Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii","Mainz","55131",{"type":61,"coordinates":404},[405,406],8.28008,49.98185,{"lat":406,"lon":405},{"facility":409,"status":55,"city":410,"state":33,"zip":411,"country":412,"cosmosGeoPoint":413,"geoPoint":417,"contacts":33},"Aou Policlinico S. Orsola-Malpighi","Bologna","40138","Italy",{"type":61,"coordinates":414},[415,416],11.33875,44.49381,{"lat":416,"lon":415},{"facility":419,"status":55,"city":420,"state":33,"zip":421,"country":412,"cosmosGeoPoint":422,"geoPoint":426,"contacts":33},"Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico","Milan","20122",{"type":61,"coordinates":423},[424,425],12.59836,42.78235,{"lat":425,"lon":424},{"facility":428,"status":55,"city":429,"state":33,"zip":430,"country":412,"cosmosGeoPoint":431,"geoPoint":435,"contacts":33},"A. Gemelli University Hospital, Catholic University of the Sacred Heart","Roma","00168",{"type":61,"coordinates":432},[433,434],11.10642,44.99364,{"lat":434,"lon":433},{"facility":437,"status":55,"city":438,"state":33,"zip":439,"country":412,"cosmosGeoPoint":440,"geoPoint":444,"contacts":33},"Azienda Sanitaria Universitaria Friuli Centrale Asu Fc","Udine","33100",{"type":61,"coordinates":441},[442,443],13.23715,46.0693,{"lat":443,"lon":442},{"facility":446,"status":55,"city":447,"state":33,"zip":448,"country":449,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"National Cancer Center Hospital East","Kashiwa Chiba","277-0882","Japan",{"facility":451,"status":55,"city":452,"state":33,"zip":453,"country":449,"cosmosGeoPoint":454,"geoPoint":458,"contacts":33},"Ehime University Hospital","Toon, Ehime","791-0204",{"type":61,"coordinates":455},[456,457],132.89011,33.79427,{"lat":457,"lon":456},{"facility":460,"status":55,"city":461,"state":33,"zip":462,"country":463,"cosmosGeoPoint":464,"geoPoint":468,"contacts":33},"Hospital Universitari Germans Trias I Pujol","Badalona","08916","Spain",{"type":61,"coordinates":465},[466,467],2.24741,41.45004,{"lat":467,"lon":466},{"facility":470,"status":55,"city":471,"state":33,"zip":472,"country":463,"cosmosGeoPoint":473,"geoPoint":477,"contacts":33},"Hospital Universitario de Gran Canaria Dr. Negrin","Las Palmas de Gran Canaria","35010",{"type":61,"coordinates":474},[475,476],-15.41573,28.10178,{"lat":476,"lon":475},{"facility":479,"status":55,"city":480,"state":33,"zip":481,"country":463,"cosmosGeoPoint":482,"geoPoint":486,"contacts":33},"Hospital Universitario 12 de Octubre","Madrid","28041",{"type":61,"coordinates":483},[484,485],-3.70256,40.4165,{"lat":485,"lon":484},{"facility":488,"status":55,"city":489,"state":33,"zip":490,"country":491,"cosmosGeoPoint":492,"geoPoint":496,"contacts":33},"Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust","London","SE1 9RT","United Kingdom",{"type":61,"coordinates":493},[494,495],-0.12574,51.50853,{"lat":495,"lon":494},{"facility":498,"status":55,"city":499,"state":33,"zip":500,"country":491,"cosmosGeoPoint":501,"geoPoint":505,"contacts":33},"Nottingham University Hospitals","Nottingham","NG5 1PB",{"type":61,"coordinates":502},[503,504],-1.15047,52.9536,{"lat":504,"lon":503},{"facility":507,"status":55,"city":508,"state":33,"zip":509,"country":491,"cosmosGeoPoint":510,"geoPoint":514,"contacts":33},"University of Oxford","Oxford","OX3 7LE",{"type":61,"coordinates":511},[512,513],-1.25596,51.75222,{"lat":513,"lon":512},{"type":516,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100626904",false,"NCT07441694","Study of INCA036978 in Participants With Myeloproliferative Neoplasms","A Phase 1, Open-Label, Multicenter Study of INCA036978 in Participants With Myeloproliferative Neoplasms","Inclusion Criteria:\n\n* Life expectancy \\> 6 months.\n* Willingness to undergo a pretreatment and limited on-study BM biopsies and aspirates (as appropriate to disease).\n* Participants with MF, PV and ET as defined in the protocol.\n\nExclusion Criteria:\n\n* Presence of any hematological malignancy other than MF, PV, or ET.\n* Malignancy within the last 3 years prior to enrollment.\n* Acute or chronic HBV, Active HCV or known HIV or tuberculosis infection.\n* Clinically significant or uncontrolled cardiac disease.\n* Has undergone any prior allogeneic stem-cell transplantation or such transplantation is planned in the next 6 months.\n* Laboratory values outside the Protocol-defined ranges.\n* Prior history of major bleeding or thrombosis within the last 3 months prior to study enrollment.\n* Presence of chronic or current active infectious disease requiring systemic treatment.\n* Treatment with an MPN-directed therapy (approved or investigational) within the per protocol threshold before the administration of study drug.\n* Prior radiation therapy within 28 days before the first dose of study treatment.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","ALL","18 Years",{"count":526,"type":527},218,"ESTIMATED","INTERVENTIONAL",[530],"PHASE1","This study will be conducted to determine the safety, tolerability, dose-limiting toxicity (DLT)s, and maximum tolerated dose (MTD) and\u002For recommended dose for expansion (RDE)s of INCA036978 administered as monotherapy and in combination with a standard disease-directed therapy.",[533],"Myeloproliferative Neoplasms",[533,535,536,537],"Myelofibrosis","Essential thrombocythemia","Polycythemia Vera","2026-05-27",{"date":540,"type":541},"2026-05-29","ACTUAL",{"date":543,"type":541},"2026-05-11",{"date":545,"type":527},"2030-05-24",{"name":5,"class":6},49]