[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100446799":3},{"organization":4,"armGroups":7,"interventions":50,"overallOfficials":56,"centralContacts":68,"locations":74,"responsibleParty":492,"collaborators":494,"id":497,"slug":56,"hasResults":498,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":498,"sex":504,"minAge":505,"maxAge":56,"enrollmentInfo":506,"targetDuration":56,"studyType":509,"phases":510,"briefSummary":513,"conditions":514,"keywords":56,"overallStatus":77,"whyStopped":56,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":528},{"fullName":5,"class":6},"Synthekine","INDUSTRY",[8,14,19,25,29,33,37,41,45],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1a: STK-012 monotherapy dose escalation","EXPERIMENTAL","STK-012 subcutaneous (SC) as monotherapy in selected solid tumor indications",[13],"Drug: STK-012",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1a: STK-012 + pembrolizumab dose escalation","STK-012 SC + pembrolizumab intravenously (IV) in selected solid tumor indications",[13,18],"Drug: pembrolizumab KEYTRUDA®",{"label":20,"type":10,"description":21,"interventionNames":22},"Phase 1a: STK-012 + standard of care (SoC) dose escalation","STK-012 SC + SoC IV in first-line non-squamous (NSQ) NSCLC",[13,18,23,24],"Drug: pemetrexed","Drug: carboplatin",{"label":26,"type":10,"description":27,"interventionNames":28},"Phase 1b: STK-012 monotherapy expansion","STK-012 SC monotherapy in selected solid tumor indications",[13],{"label":30,"type":10,"description":31,"interventionNames":32},"Phase 1b: STK-012 + pembrolizumab dose expansion","STK-012 SC will be administered in combination with pembrolizumab IV in selected solid tumor indications",[13,18],{"label":34,"type":10,"description":35,"interventionNames":36},"Phase 1b: STK-012 + SoC dose expansion","STK-012 SC + SoC IV in first-line PD-L1 negative NSQ NSCLC",[13,18,23,24],{"label":38,"type":10,"description":39,"interventionNames":40},"Phase 2: Arm A","STK-012 2.25 mg SC Q3W + SoC IV in first-line PD-L1 negative or STK11 mutated, NSQ NSCLC",[13,18,23,24],{"label":42,"type":10,"description":43,"interventionNames":44},"Phase 2: Arm B","STK-012 1.5 mg SC Q3W + SoC IV in first-line PD-L1 negative or STK11 mutated, NSQ NSCLC",[13,18,23,24],{"label":46,"type":47,"description":48,"interventionNames":49},"Phase 2: Arm C","ACTIVE_COMPARATOR","SoC IV in first-line PD-L1 negative or STK11 mutated, NSQ NSCLC",[18,23,24],[51,57,61,65],{"type":52,"name":53,"description":54,"armGroupLabels":55,"otherNames":56},"DRUG","STK-012","Engineered Interleukin-2 (IL-2) selective for antigen activated T cells",[15,20,9,34,30,26,38,42],null,{"type":52,"name":58,"description":59,"armGroupLabels":60,"otherNames":56},"pembrolizumab KEYTRUDA®","anti-PD-1 monoclonal antibody",[15,20,34,30,38,42,46],{"type":52,"name":62,"description":63,"armGroupLabels":64,"otherNames":56},"pemetrexed","chemotherapy",[20,34,38,42,46],{"type":52,"name":66,"description":63,"armGroupLabels":67,"otherNames":56},"carboplatin",[20,34,38,42,46],[69],{"name":70,"role":71,"phone":72,"phoneExt":56,"email":73},"Synthekine STK-012-101 Contact","CONTACT","650-606-6319","STK-012-101.contact@synthekine.com",[75,88,98,107,117,126,135,144,154,164,174,184,194,204,210,215,225,235,243,249,255,265,275,284,294,304,314,324,333,344,353,361,371,381,390,399,404,409,419,425,431,440,450,459,468,474,483],{"facility":76,"status":77,"city":78,"state":79,"zip":80,"country":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":56},"University of Arizona Cancer Center","RECRUITING","Tucson","Arizona","85721","United States",{"type":83,"coordinates":84},"Point",[85,86],-110.92648,32.22174,{"lat":86,"lon":85},{"facility":89,"status":77,"city":90,"state":91,"zip":92,"country":81,"cosmosGeoPoint":93,"geoPoint":97,"contacts":56},"Beverly Hills Cancer Center","Beverly Hills","California","90211",{"type":83,"coordinates":94},[95,96],-118.40036,34.07362,{"lat":96,"lon":95},{"facility":99,"status":77,"city":100,"state":91,"zip":101,"country":81,"cosmosGeoPoint":102,"geoPoint":106,"contacts":56},"Providence Medical Foundation","Fullerton","92835",{"type":83,"coordinates":103},[104,105],-117.92534,33.87029,{"lat":105,"lon":104},{"facility":108,"status":109,"city":110,"state":91,"zip":111,"country":81,"cosmosGeoPoint":112,"geoPoint":116,"contacts":56},"UC San Diego Moores Cancer Center","ACTIVE_NOT_RECRUITING","La Jolla","92093-0698",{"type":83,"coordinates":113},[114,115],-117.2742,32.84727,{"lat":115,"lon":114},{"facility":118,"status":77,"city":119,"state":91,"zip":120,"country":81,"cosmosGeoPoint":121,"geoPoint":125,"contacts":56},"Cedars Sinai","Los Angeles","90048",{"type":83,"coordinates":122},[123,124],-118.24368,34.05223,{"lat":124,"lon":123},{"facility":127,"status":77,"city":128,"state":91,"zip":129,"country":81,"cosmosGeoPoint":130,"geoPoint":134,"contacts":56},"Hoag Memorial Hospital Presbyterian","Newport Beach","92663",{"type":83,"coordinates":131},[132,133],-117.92895,33.61891,{"lat":133,"lon":132},{"facility":136,"status":77,"city":137,"state":91,"zip":138,"country":81,"cosmosGeoPoint":139,"geoPoint":143,"contacts":56},"UCLA Hematology\u002FOncology - Santa Monica","Santa Monica","90404",{"type":83,"coordinates":140},[141,142],-118.49138,34.01949,{"lat":142,"lon":141},{"facility":145,"status":77,"city":146,"state":147,"zip":148,"country":81,"cosmosGeoPoint":149,"geoPoint":153,"contacts":56},"Yale New Haven Hospital, Yale Cancer Center","New Haven","Connecticut","06510",{"type":83,"coordinates":150},[151,152],-72.92816,41.30815,{"lat":152,"lon":151},{"facility":155,"status":77,"city":156,"state":157,"zip":158,"country":81,"cosmosGeoPoint":159,"geoPoint":163,"contacts":56},"Georgetown University","Washington D.C.","District of Columbia","20057",{"type":83,"coordinates":160},[161,162],-77.03637,38.89511,{"lat":162,"lon":161},{"facility":165,"status":77,"city":166,"state":167,"zip":168,"country":81,"cosmosGeoPoint":169,"geoPoint":173,"contacts":56},"Winship Cancer Institute, Emory University","Atlanta","Georgia","30322",{"type":83,"coordinates":170},[171,172],-84.38798,33.749,{"lat":172,"lon":171},{"facility":175,"status":77,"city":176,"state":177,"zip":178,"country":81,"cosmosGeoPoint":179,"geoPoint":183,"contacts":56},"University of Chicago","Chicago","Illinois","60637",{"type":83,"coordinates":180},[181,182],-87.65005,41.85003,{"lat":182,"lon":181},{"facility":185,"status":77,"city":186,"state":187,"zip":188,"country":81,"cosmosGeoPoint":189,"geoPoint":193,"contacts":56},"University of Maryland","Baltimore","Maryland","21201",{"type":83,"coordinates":190},[191,192],-76.61219,39.29038,{"lat":192,"lon":191},{"facility":195,"status":77,"city":196,"state":197,"zip":198,"country":81,"cosmosGeoPoint":199,"geoPoint":203,"contacts":56},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":83,"coordinates":200},[201,202],-71.05977,42.35843,{"lat":202,"lon":201},{"facility":205,"status":77,"city":196,"state":197,"zip":206,"country":81,"cosmosGeoPoint":207,"geoPoint":209,"contacts":56},"Beth Israel Deaconess Medical Center","02215",{"type":83,"coordinates":208},[201,202],{"lat":202,"lon":201},{"facility":211,"status":77,"city":196,"state":197,"zip":206,"country":81,"cosmosGeoPoint":212,"geoPoint":214,"contacts":56},"Dana-Farber Cancer Institute",{"type":83,"coordinates":213},[201,202],{"lat":202,"lon":201},{"facility":216,"status":77,"city":217,"state":218,"zip":219,"country":81,"cosmosGeoPoint":220,"geoPoint":224,"contacts":56},"HealthPartners Cancer Center at Regions Hospital","Saint Paul","Minnesota","55101",{"type":83,"coordinates":221},[222,223],-93.09327,44.94441,{"lat":223,"lon":222},{"facility":226,"status":77,"city":227,"state":228,"zip":229,"country":81,"cosmosGeoPoint":230,"geoPoint":234,"contacts":56},"Northwell Health","Lake Success","New York","11042",{"type":83,"coordinates":231},[232,233],-73.71763,40.77066,{"lat":233,"lon":232},{"facility":236,"status":77,"city":228,"state":228,"zip":237,"country":81,"cosmosGeoPoint":238,"geoPoint":242,"contacts":56},"NYU Langone Health","10016",{"type":83,"coordinates":239},[240,241],-74.00597,40.71427,{"lat":241,"lon":240},{"facility":244,"status":109,"city":228,"state":228,"zip":245,"country":81,"cosmosGeoPoint":246,"geoPoint":248,"contacts":56},"Columbia University Irving Medical Center","10032",{"type":83,"coordinates":247},[240,241],{"lat":241,"lon":240},{"facility":250,"status":77,"city":228,"state":228,"zip":251,"country":81,"cosmosGeoPoint":252,"geoPoint":254,"contacts":56},"Memorial Sloan-Kettering Cancer Center","10065",{"type":83,"coordinates":253},[240,241],{"lat":241,"lon":240},{"facility":256,"status":109,"city":257,"state":258,"zip":259,"country":81,"cosmosGeoPoint":260,"geoPoint":264,"contacts":56},"Duke Cancer Center","Durham","North Carolina","27710",{"type":83,"coordinates":261},[262,263],-78.89862,35.99403,{"lat":263,"lon":262},{"facility":266,"status":77,"city":267,"state":268,"zip":269,"country":81,"cosmosGeoPoint":270,"geoPoint":274,"contacts":56},"University Hospitals Cleveland","Cleveland","Ohio","44106",{"type":83,"coordinates":271},[272,273],-81.69541,41.4995,{"lat":273,"lon":272},{"facility":276,"status":77,"city":277,"state":268,"zip":278,"country":81,"cosmosGeoPoint":279,"geoPoint":283,"contacts":56},"The James Cancer Hospital and Solove Research Institute","Columbus","43210",{"type":83,"coordinates":280},[281,282],-82.99879,39.96118,{"lat":282,"lon":281},{"facility":285,"status":77,"city":286,"state":287,"zip":288,"country":81,"cosmosGeoPoint":289,"geoPoint":293,"contacts":56},"Providence Cancer Institute","Portland","Oregon","97123",{"type":83,"coordinates":290},[291,292],-122.67621,45.52345,{"lat":292,"lon":291},{"facility":295,"status":77,"city":296,"state":297,"zip":298,"country":81,"cosmosGeoPoint":299,"geoPoint":303,"contacts":56},"Fox Chase Cancer Center","Philadelphia","Pennsylvania","19111",{"type":83,"coordinates":300},[301,302],-75.16362,39.95238,{"lat":302,"lon":301},{"facility":305,"status":306,"city":307,"state":297,"zip":308,"country":81,"cosmosGeoPoint":309,"geoPoint":313,"contacts":56},"UPMC Hillman Cancer Center","TERMINATED","Pittsburgh","15232",{"type":83,"coordinates":310},[311,312],-79.99589,40.44062,{"lat":312,"lon":311},{"facility":315,"status":109,"city":316,"state":317,"zip":318,"country":81,"cosmosGeoPoint":319,"geoPoint":323,"contacts":56},"Baptist Memorial Hospital Cancer Center","Memphis","Tennessee","38120",{"type":83,"coordinates":320},[321,322],-90.04898,35.14953,{"lat":322,"lon":321},{"facility":325,"status":109,"city":326,"state":317,"zip":327,"country":81,"cosmosGeoPoint":328,"geoPoint":332,"contacts":56},"Sarah Cannon Research Institute - Nashville","Nashville","37203",{"type":83,"coordinates":329},[330,331],-86.78444,36.16589,{"lat":331,"lon":330},{"facility":334,"status":335,"city":336,"state":337,"zip":338,"country":81,"cosmosGeoPoint":339,"geoPoint":343,"contacts":56},"Renovatio Clinical","WITHDRAWN","El Paso","Texas","79915",{"type":83,"coordinates":340},[341,342],-106.48693,31.75872,{"lat":342,"lon":341},{"facility":345,"status":77,"city":346,"state":337,"zip":347,"country":81,"cosmosGeoPoint":348,"geoPoint":352,"contacts":56},"Oncology Consultants","Houston","77303",{"type":83,"coordinates":349},[350,351],-95.36327,29.76328,{"lat":351,"lon":350},{"facility":334,"status":335,"city":354,"state":337,"zip":355,"country":81,"cosmosGeoPoint":356,"geoPoint":360,"contacts":56},"The Woodlands","77380",{"type":83,"coordinates":357},[358,359],-95.48938,30.15799,{"lat":359,"lon":358},{"facility":362,"status":77,"city":363,"state":364,"zip":365,"country":81,"cosmosGeoPoint":366,"geoPoint":370,"contacts":56},"NEXT Virginia","Fairfax","Virginia","22031",{"type":83,"coordinates":367},[368,369],-77.30637,38.84622,{"lat":369,"lon":368},{"facility":372,"status":109,"city":373,"state":374,"zip":375,"country":81,"cosmosGeoPoint":376,"geoPoint":380,"contacts":56},"Northwest Medical Specialties","Tacoma","Washington","98405",{"type":83,"coordinates":377},[378,379],-122.44429,47.25288,{"lat":379,"lon":378},{"facility":382,"status":77,"city":383,"state":56,"zip":384,"country":167,"cosmosGeoPoint":385,"geoPoint":389,"contacts":56},"LTD High Technology Hospital Medcenter","Batumi","6000",{"type":83,"coordinates":386},[387,388],41.6306,41.64077,{"lat":388,"lon":387},{"facility":391,"status":77,"city":392,"state":56,"zip":393,"country":167,"cosmosGeoPoint":394,"geoPoint":398,"contacts":56},"Caraps Medline, Ltd (JSC VIAN)","Tbilisi","0159",{"type":83,"coordinates":395},[396,397],44.83412,41.69143,{"lat":397,"lon":396},{"facility":400,"status":77,"city":392,"state":56,"zip":393,"country":167,"cosmosGeoPoint":401,"geoPoint":403,"contacts":56},"Institute of Clinical Oncology (ICO)",{"type":83,"coordinates":402},[396,397],{"lat":397,"lon":396},{"facility":405,"status":77,"city":392,"state":56,"zip":393,"country":167,"cosmosGeoPoint":406,"geoPoint":408,"contacts":56},"Israel Georgian Medical Research Clinic Healthycore",{"type":83,"coordinates":407},[396,397],{"lat":397,"lon":396},{"facility":410,"status":77,"city":411,"state":56,"zip":412,"country":413,"cosmosGeoPoint":414,"geoPoint":418,"contacts":56},"START Dublin","Dublin","07","Ireland",{"type":83,"coordinates":415},[416,417],-6.24889,53.33306,{"lat":417,"lon":416},{"facility":420,"status":77,"city":411,"state":56,"zip":421,"country":413,"cosmosGeoPoint":422,"geoPoint":424,"contacts":56},"St. James Hospital","08",{"type":83,"coordinates":423},[416,417],{"lat":417,"lon":416},{"facility":426,"status":77,"city":411,"state":56,"zip":427,"country":413,"cosmosGeoPoint":428,"geoPoint":430,"contacts":56},"Beaumont Hospital","09",{"type":83,"coordinates":429},[416,417],{"lat":417,"lon":416},{"facility":432,"status":77,"city":433,"state":56,"zip":434,"country":413,"cosmosGeoPoint":435,"geoPoint":439,"contacts":56},"University Hospital Galway","Galway","H91 YR71",{"type":83,"coordinates":436},[437,438],-9.05095,53.27245,{"lat":438,"lon":437},{"facility":441,"status":77,"city":442,"state":56,"zip":443,"country":444,"cosmosGeoPoint":445,"geoPoint":449,"contacts":56},"Hospital Quirón Barcelona","Barcelona","08023","Spain",{"type":83,"coordinates":446},[447,448],2.15899,41.38879,{"lat":448,"lon":447},{"facility":451,"status":77,"city":452,"state":56,"zip":453,"country":444,"cosmosGeoPoint":454,"geoPoint":458,"contacts":56},"START Rioja","Logroño","26006",{"type":83,"coordinates":455},[456,457],-2.45115,42.46615,{"lat":457,"lon":456},{"facility":460,"status":77,"city":461,"state":56,"zip":462,"country":444,"cosmosGeoPoint":463,"geoPoint":467,"contacts":56},"MD Anderson","Madrid","28033",{"type":83,"coordinates":464},[465,466],-3.70256,40.4165,{"lat":466,"lon":465},{"facility":469,"status":77,"city":461,"state":56,"zip":470,"country":444,"cosmosGeoPoint":471,"geoPoint":473,"contacts":56},"Hospital Universitario Ramon y Cajal","28034",{"type":83,"coordinates":472},[465,466],{"lat":466,"lon":465},{"facility":475,"status":77,"city":476,"state":56,"zip":477,"country":444,"cosmosGeoPoint":478,"geoPoint":482,"contacts":56},"Hospital Regional de Málaga","Málaga","29011",{"type":83,"coordinates":479},[480,481],-4.42034,36.72016,{"lat":481,"lon":480},{"facility":484,"status":77,"city":485,"state":56,"zip":486,"country":444,"cosmosGeoPoint":487,"geoPoint":491,"contacts":56},"Clinica Universidad de Navarra - Pamplona","Pamplona","31008",{"type":83,"coordinates":488},[489,490],-1.64323,42.81687,{"lat":490,"lon":489},{"type":493,"investigatorFullName":56,"investigatorTitle":56,"investigatorAffiliation":56,"oldNameTitle":56,"oldOrganization":56},"SPONSOR",[495],{"name":496,"class":6},"Merck Sharp & Dohme LLC","100446799",false,"NCT05098132","Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers","A Phase 1\u002F2 Study to Evaluate STK-012 as a Single Agent and in Combination Therapy in Subjects With Front-line Advanced NSCLC and Other Selected Indications","SYNERGY-101","Selected Inclusion Criteria:\n\n1. Phase 1: Selected advanced solid tumors\n2. Phase 2:\n\n   * Diagnosis of non-small cell lung cancer (NSCLC).\n   * Stage IV or Stage IIIB\u002FIIIC and not a candidate for definitive treatment.\n   * Non-squamous (NSQ) cell histology.\n   * No prior systemic therapy for advanced\u002Fmetastatic NSQ NSCLC.\n   * Must have a tumor that meets at least one of the following criteria on local testing:\n\n     * PD-L1 negative (TPS \\\u003C1%), OR;\n     * STK11 mutated on tumor tissue or ctDNA\n   * No known actionable EGFR, ALK, ROS1, or other actionable genomic aberrations for which there is a local standard of care available as front line therapy.\n\nSelected Exclusion Criteria:\n\n2\\. Phase 2:\n\n* Prior immune checkpoint inhibitor (anti-PD\\[L\\]1 and\u002For anti-CTLA-4) treatment\n* Rare tumor subtypes (mucinous histology or tumors with small cell, neuroendocrine, or sarcomatoid components).\n* Received radiotherapy ≤ 7 days of the first dose of study treatment.\n* Known active central nervous system metastases\n* Any history of carcinomatous meningitis","ALL","18 Years",{"count":507,"type":508},364,"ESTIMATED","INTERVENTIONAL",[511,512],"PHASE1","PHASE2","This is a phase 1\u002F2, multicenter, open-label study. The phase 1 portion is a dose escalation and expansion study of STK-012 as monotherapy and in combination therapy in patients with selected advanced solid tumors. The phase 2 portion is a randomized study of STK-012 in combination with standard of care (SoC) pembrolizumab, pemetrexed, and carboplatin versus SoC, in patients with first line, PD-L1 negative or STK11 mutated, non-squamous, non-small cell lung cancer.",[515,516,517,518],"Advanced Solid Tumor","Non Small Cell Lung Cancer","Untreated Advanced NSCLC","1st Line NSCLC","2026-06-24",{"date":521,"type":522},"2026-06-29","ACTUAL",{"date":524,"type":522},"2022-01-25",{"date":526,"type":508},"2029-01",{"name":5,"class":6},47]