[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613260":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":69,"collaborators":11,"id":71,"slug":11,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":11,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":11,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":94,"overallStatus":44,"whyStopped":11,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Consano Bio","INDUSTRY",[8,15,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1 - Low dose","EXPERIMENTAL",null,[13,14],"Drug: C-1101","Other: Placebo: Sterile Saline",{"label":16,"type":10,"description":11,"interventionNames":17},"Cohort 2 - Mid dose",[13,14],{"label":19,"type":10,"description":11,"interventionNames":20},"Cohort 3 - High dose",[13,14],[22,26],{"type":23,"name":24,"description":24,"armGroupLabels":25,"otherNames":11},"DRUG","C-1101",[9,16,19],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"OTHER","Placebo: Sterile Saline","Placebo",[9,16,19],[32],{"name":33,"affiliation":5,"role":34},"Consano Chief Medical Officer","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Senior Director, Clinical Development Operations","CONTACT","AUS: +61 (1800) 057510","clindev@consanobio.com",[42,54,61],{"facility":43,"status":44,"city":45,"state":46,"zip":11,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":11},"Consano Bio Research Site","RECRUITING","Broadmeadow","New South Wales","Australia",{"type":49,"coordinates":50},"Point",[51,52],151.72849,-32.92371,{"lat":52,"lon":51},{"facility":43,"status":44,"city":55,"state":46,"zip":11,"country":47,"cosmosGeoPoint":56,"geoPoint":60,"contacts":11},"Wahroonga",{"type":49,"coordinates":57},[58,59],151.11561,-33.71816,{"lat":59,"lon":58},{"facility":43,"status":44,"city":62,"state":63,"zip":11,"country":47,"cosmosGeoPoint":64,"geoPoint":68,"contacts":11},"Melbourne","Victoria",{"type":49,"coordinates":65},[66,67],144.96332,-37.814,{"lat":67,"lon":66},{"type":70,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100613260",false,"NCT07264270","Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","Inclusion Criteria:\n\n* Diagnosis of painful LSR (sciatica) radiating to or below the knee, with an inadequate response to conservative care\n* Body mass index \\\u003C 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Presence of clinically significant disease or any other painful condition that may interfere with assessments.\n* Any condition that currently requires blood or platelet transfusions.\n* Diagnosed with schizophrenia, bipolar disorder, or major depressive disorder.\n* Increased risk of bleeding or is taking anticoagulants or platelet aggregation inhibitors.\n* History or presence of autonomic neuropathy, diabetic neuropathy, or other peripheral neuropathies.\n* History of myocardial infarction within the last 6 months or congestive heart failure.\n* The presence of an active malignancy or tumor.\n* Have undergone a surgical procedure for back pain.\n* Recent use of immunosuppressants, oral steroids, or intravenous steroids.","ALL","18 Years","65 Years",{"count":81,"type":82},24,"ESTIMATED","INTERVENTIONAL",[85],"PHASE1","The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline",[88,89,90,91,92,93],"Lumbosacral Radicular Pain","Sciatic Radiculopathy","Sciatic Leg Pain","Sciatica","Lumbosacral Radicular Syndrome","Lumbosacral Radiculopathy",[91,95,96,97,93,98,99,100],"Sciatic Nerve Pain","LSR","back pain","Chronic Painful Lumbosacral Radiculopathy","non-opioid pain medication","transforaminal epidural injection","2026-03-16",{"date":103,"type":104},"2026-03-17","ACTUAL",{"date":106,"type":104},"2025-12-03",{"date":108,"type":82},"2026-12-01",{"name":5,"class":6},3]