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is older than 18 years) at time of signing informed consent.\n* Participants with histologically or cytologically confirmed ES-SCLC that progressed or recurred following at least one line of platinum-based anti-cancer therapy for SCLC.\n\nNote: Participants with prior treatment for LS-SCLC should have also received another regimen for their recurrent, ES-SCLC disease.\n\n* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1.\n* Participants must have adequate organ function (cardiac, pulmonary, kidney, and liver).\n* Participants must be able to have SC injections administered in the abdomen.\n* Participants without measurable disease or tumor tissue (fresh biopsy or archival) available may be permitted after discussion with and approval by Amgen Medical Monitor.\n\nExclusion Criteria:\n\n* Participants that have received prior DLL3 targeted therapy.\n* Participants with untreated or symptomatic brain metastases or those requiring therapy with steroids.\n* Note: Participants with asymptomatic brain metastatic lesions are allowed following definitive treatment (Amgen Medical Monitor may approve untreated, asymptomatic brain metastasis if local therapy is not required per investigator judgment).\n* Participants with leptomeningeal disease.\n* Participants with baseline oxygen requirement.","ALL","18 Years",{"count":362,"type":363},220,"ESTIMATED","INTERVENTIONAL",[366],"PHASE1","The primary objective of this study is to evaluate the safety and tolerability of subcutaneous (SC) tarlatamab.",[369],"Extensive Stage Small Cell Lung Cancer",[371],"Small Cell Lung Cancer","2026-06-25",{"date":374,"type":375},"2026-06-26","ACTUAL",{"date":377,"type":375},"2024-10-07",{"date":379,"type":363},"2030-04-24",{"name":5,"class":6},31]