[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558766":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":62,"collaborators":34,"id":64,"slug":34,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":34,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":34,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":47,"whyStopped":34,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Alberta","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Egg white powder (20g)","PLACEBO_COMPARATOR","20 g of egg white powder from the market; negative control; only individuals at risk of diabetes\u002Fhaving type 2 diabetes.",[13],"Dietary Supplement: Egg White Powder",{"label":15,"type":16,"description":17,"interventionNames":18},"Egg white hydrolysate Thermoase (5 g) (powder)","EXPERIMENTAL","5 g; dose based on human equivalent dose calculation; only individuals at risk of diabetes\u002Fhaving type 2 diabetes",[13],{"label":20,"type":16,"description":21,"interventionNames":22},"Egg white hydrolysate Thermoase (20 g) (powder)","20 g; dose based on energy percentage used in animal experiment; both healthy control group and at risk of diabetes\u002Fhaving type 2 diabetes",[13],{"label":24,"type":25,"description":26,"interventionNames":27},"Egg white hydrolysate Thermoase + Pepsin (20 g) liberating IRW (powder)","ACTIVE_COMPARATOR","20 g; positive control, only individuals at risk of diabetes\u002Fhaving type 2 diabetes",[13],[29],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DIETARY_SUPPLEMENT","Egg White Powder","Participants will consume a standardized breakfast (2 slices of 70 g whole wheat bread, 10 g of butter and 30 g of strawberry jam) followed by a smoothie containing the powder. The Egg White Powder will be incorporated in the standardized smoothie containing water, fruits and chocolate\u002Fstrawberry syrup totaling 250 Kcal. The total calories of the breakfast will be adapted to the calorie needs of each participant to account for 20-25% of their daily calorie intake.\n\nAfter a 9 h fast, blood will be taken before consumption of the standardized breakfast and smoothie (T= 0) and at 5, 10, 20, 30, 60, 90, 120, and 180 min after consumption of the smoothie. Participants will be given 15-25 minutes to eat their breakfast. Urine samples will be collected from participants before the smoothie consumption (0 h) and at 30 min, 90 min, 150 min, 6 hours, 12 hours, and 24 hours following consumption.",[20,15,24,9],null,[36],{"name":37,"affiliation":5,"role":38},"Jianping Wu, PhD","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":34,"email":44},"Paulina Blanco Cervantes, MSc","CONTACT","7804929506","blancoce@ualberta.ca",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Edmonton","Alberta","T6G 2P5","Canada",{"type":53,"coordinates":54},"Point",[55,56],-113.46871,53.55014,{"lat":56,"lon":55},[59],{"name":60,"role":61,"phone":34,"phoneExt":34,"email":34},"Caroline Richard, PhD, RD","SUB_INVESTIGATOR",{"type":63,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100558766",false,"NCT06555393","Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study","A Preliminary Human Study on Bioavailability and Efficacy of Bioactive Peptide IRW in Egg White Hydrolysate","Inclusion Criteria:\n\nHealthy control group:\n\n* Men and women aged between 18 and 70 years living in Edmonton (or Edmonton area\u002Fdriving distance).\n* Normal weight (BMI below 25 kg\u002Fm2 or Asian population below 23 kg\u002Fm2 )\n* Waist circumference below the following ethnic specific cut offs: Canada \u002F USA: \\\u003C102 cm men and \\\u003C88 cm women; Europids, Middle-Eastern, Sub-Saharan African, and Mediterranean: \\\u003C94 cm men and \\\u003C80 cm women; Asians, Japanese, South and Central Americans: \\\u003C90 cm men and \\\u003C80 cm women\n* Fasting glucose \\\u003C5.6 mmol\u002FL\n* HbA1c \\\u003C5.6 %\n* Blood pressure \\\u003C130\u002F85 mmHg\n* Triglycerides \\\u003C1.7 mmol\u002FL\n* HDL-Cholesterol \\>1.03 mmol\u002FL men and \\>1.29 mmol\u002FL women\n* Body weight stable (within 3% fluctuation) for at least 6 months prior to the study\n* Individuals who have never smoke, have smoke less than 100 cigarettes in their life or who are long term quitter (quit smoking a year or more ago)\n\nIndividuals at risk of diabetes\u002Fhaving type 2 diabetes:\n\n* Men and women aged between 18 and 70 years living in Edmonton (or Edmonton area\u002Fdriving distance).\n* Overweight or obesity (BMI above 25 kg\u002Fm2 or Asian population above 23 kg\u002Fm2)\n* Waist circumference at or above the following ethnic specific cut offs: Canada \u002F USA: ≥ 102 cm men and ≥ 88 cm women; Europids, Middle-Eastern, Sub-Saharan African, and Mediterranean: ≥ 94 cm men and ≥ 80 cm women; Asians, Japanese, South and Central Americans: ≥ 90 cm men and ≥ 80 cm women\n* Fasting glucose ≥ 6.0 mmol\u002FL\n* HbA1c ≥ 6.0 %\n* Body weight stable (within 3% fluctuation) for at least 6 months prior to the study\n* Individuals who have never smoke, have smoke less than 100 cigarettes in their life or who are long term quitter (quit smoking a year or more ago)\n\nExclusion Criteria:\n\n* Individuals with a previous history of CVD, renal disorder, monogenic dyslipidemia, with endocrine disorders other than T2D\n* Individuals taking chronic anti-inflammatory drugs (including aspirin, antihistamines, and omega-3 supplements)\n* Pregnant\u002Flactating women\n* Individuals aged above 70 years\n* Smokers (current smokers: daily\u002Foccasional and those who have smoked more than 100 cigarettes in their life)\n* Individuals with specific nutritional restrictions (e.g. vegetarianism excluding eggs from their diet, vegan or with egg allergy) will be excluded\n* Individuals with poorly controlled (HbA1c \\>12.0%) diabetes or taking exogenous insulin will be excluded. Other anti-diabetic and lipid-lowering medications will be documented.",true,"ALL","18 Years","70 Years",{"count":75,"type":76},28,"ESTIMATED","INTERVENTIONAL",[79],"PHASE1","Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure.\n\nParticipants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week.\n\nParticipants in the healthy control group will undergo 1 treatment only (one day).",[82,83,84],"High Blood Sugar","High Blood Pressure","Overweight and Obesity",[86,87,88,89],"high blood pressure","high blood sugar","overweight","obesity","2026-03-12",{"date":92,"type":93},"2026-03-13","ACTUAL",{"date":95,"type":93},"2026-02-25",{"date":97,"type":76},"2026-10",{"name":5,"class":6},1]