[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600388":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":425,"collaborators":11,"id":427,"slug":11,"hasResults":428,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":432,"eligibilityCriteria":433,"healthyVolunteers":428,"sex":434,"minAge":435,"maxAge":436,"enrollmentInfo":437,"targetDuration":11,"studyType":440,"phases":441,"briefSummary":443,"conditions":444,"keywords":446,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":438},{"fullName":5,"class":6},"Climb Bio, Inc.","INDUSTRY",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1: Dose Level A","EXPERIMENTAL",null,[13],"Drug: budoprutug",{"label":15,"type":10,"description":11,"interventionNames":16},"Cohort 2: Dose Level B",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Cohort 3: Dose Level C",[13],[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","budoprutug","Single IV dose of study product on Day 1, Day 15, Day 169 and Day 183",[9,15,18],[27],"TNT119",[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Climb Bio Study Director","CONTACT","+1 866 857 2596","clinicaltrials@climbbio.com",[35,48,58,68,78,88,99,109,118,128,134,138,141,149,158,168,177,186,195,204,209,220,230,240,251,258,268,278,288,298,307,317,324,333,339,345,355,364,370,376,382,392,401,407,416],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":11},"Climb Bio Investigative Site #110","RECRUITING","Denver","Colorado","80220","United States",{"type":43,"coordinates":44},"Point",[45,46],-104.9847,39.73915,{"lat":46,"lon":45},{"facility":49,"status":37,"city":50,"state":51,"zip":52,"country":41,"cosmosGeoPoint":53,"geoPoint":57,"contacts":11},"Climb Bio Investigative Site #105","Orlando","Florida","32086",{"type":43,"coordinates":54},[55,56],-81.37924,28.53834,{"lat":56,"lon":55},{"facility":59,"status":37,"city":60,"state":61,"zip":62,"country":41,"cosmosGeoPoint":63,"geoPoint":67,"contacts":11},"Climb Bio Investigative Site #108","Atlanta","Georgia","30342",{"type":43,"coordinates":64},[65,66],-84.38798,33.749,{"lat":66,"lon":65},{"facility":69,"status":37,"city":70,"state":71,"zip":72,"country":41,"cosmosGeoPoint":73,"geoPoint":77,"contacts":11},"Climb Bio Investigative Site #106","Indianapolis","Indiana","46268",{"type":43,"coordinates":74},[75,76],-86.15804,39.76838,{"lat":76,"lon":75},{"facility":79,"status":37,"city":80,"state":81,"zip":82,"country":41,"cosmosGeoPoint":83,"geoPoint":87,"contacts":11},"Climb Bio Investigative Site #101","Clifton Park","New York","12065",{"type":43,"coordinates":84},[85,86],-73.77095,42.86563,{"lat":86,"lon":85},{"facility":89,"status":90,"city":91,"state":92,"zip":93,"country":41,"cosmosGeoPoint":94,"geoPoint":98,"contacts":11},"Climb Bio Investigative Site #102","NOT_YET_RECRUITING","Philadelphia","Pennsylvania","19104",{"type":43,"coordinates":95},[96,97],-75.16362,39.95238,{"lat":97,"lon":96},{"facility":100,"status":37,"city":101,"state":102,"zip":103,"country":41,"cosmosGeoPoint":104,"geoPoint":108,"contacts":11},"Climb Bio Investigative Site #103","El Paso","Texas","79932",{"type":43,"coordinates":105},[106,107],-106.48693,31.75872,{"lat":107,"lon":106},{"facility":110,"status":37,"city":111,"state":102,"zip":112,"country":41,"cosmosGeoPoint":113,"geoPoint":117,"contacts":11},"Climb Bio Investigative Site #104","Sherman","75092",{"type":43,"coordinates":114},[115,116],-96.60888,33.63566,{"lat":116,"lon":115},{"facility":119,"status":37,"city":120,"state":11,"zip":121,"country":122,"cosmosGeoPoint":123,"geoPoint":127,"contacts":11},"Climb Bio Investigative Site# 602","Buenos Aires","B1629","Argentina",{"type":43,"coordinates":124},[125,126],-58.37723,-34.61315,{"lat":126,"lon":125},{"facility":129,"status":37,"city":120,"state":11,"zip":130,"country":122,"cosmosGeoPoint":131,"geoPoint":133,"contacts":11},"Climb Bio Investigative Site# 603","B1888",{"type":43,"coordinates":132},[125,126],{"lat":126,"lon":125},{"facility":135,"status":37,"city":136,"state":11,"zip":137,"country":122,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Climb Bio Investigative Site #601","CABA","C1111",{"facility":139,"status":37,"city":136,"state":11,"zip":140,"country":122,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"Climb Bio Investigative Site #604","C1425",{"facility":142,"status":90,"city":143,"state":11,"zip":140,"country":122,"cosmosGeoPoint":144,"geoPoint":148,"contacts":11},"Climb Bio Investigative Site #605","Córdoba",{"type":43,"coordinates":145},[146,147],-64.18853,-31.40648,{"lat":147,"lon":146},{"facility":150,"status":37,"city":151,"state":11,"zip":152,"country":122,"cosmosGeoPoint":153,"geoPoint":157,"contacts":11},"Climb Bio Investigative Site #606","Santa Fe","S3000",{"type":43,"coordinates":154},[155,156],-60.70868,-31.64881,{"lat":156,"lon":155},{"facility":159,"status":37,"city":160,"state":11,"zip":161,"country":162,"cosmosGeoPoint":163,"geoPoint":167,"contacts":11},"Climb Bio Investigative Site #502","Belo Horizonte","30150-320","Brazil",{"type":43,"coordinates":164},[165,166],-43.93778,-19.92083,{"lat":166,"lon":165},{"facility":169,"status":37,"city":170,"state":11,"zip":171,"country":162,"cosmosGeoPoint":172,"geoPoint":176,"contacts":11},"Climb Bio Investigative Site #505","Minas Gerais","36010-570",{"type":43,"coordinates":173},[174,175],-72.78333,-8.96667,{"lat":175,"lon":174},{"facility":178,"status":90,"city":179,"state":11,"zip":180,"country":162,"cosmosGeoPoint":181,"geoPoint":185,"contacts":11},"Climb Bio Investigative Site #506","Pernambuco","50670-901",{"type":43,"coordinates":182},[183,184],-71.47582,-6.98059,{"lat":184,"lon":183},{"facility":187,"status":37,"city":188,"state":11,"zip":189,"country":162,"cosmosGeoPoint":190,"geoPoint":194,"contacts":11},"Climb Bio Investigative Site #501","Porto Alegre","90020-090",{"type":43,"coordinates":191},[192,193],-51.23019,-30.03283,{"lat":193,"lon":192},{"facility":196,"status":37,"city":197,"state":11,"zip":198,"country":162,"cosmosGeoPoint":199,"geoPoint":203,"contacts":11},"Climb Bio Investigative Site #503","São Paulo","05403-000",{"type":43,"coordinates":200},[201,202],-46.63611,-23.5475,{"lat":202,"lon":201},{"facility":205,"status":37,"city":197,"state":11,"zip":198,"country":162,"cosmosGeoPoint":206,"geoPoint":208,"contacts":11},"Climb Bio Investigative Site #504",{"type":43,"coordinates":207},[201,202],{"lat":202,"lon":201},{"facility":210,"status":90,"city":211,"state":212,"zip":213,"country":214,"cosmosGeoPoint":215,"geoPoint":219,"contacts":11},"Climb Bio Investigative Site #701","Temuco","Araucania","4811230","Chile",{"type":43,"coordinates":216},[217,218],-72.59738,-38.73628,{"lat":218,"lon":217},{"facility":221,"status":90,"city":222,"state":223,"zip":224,"country":214,"cosmosGeoPoint":225,"geoPoint":229,"contacts":11},"Climb Bio Investigative Site #703","Valdivia","Los Ríos Region","5020000",{"type":43,"coordinates":226},[227,228],-73.24589,-39.81422,{"lat":228,"lon":227},{"facility":231,"status":90,"city":232,"state":233,"zip":234,"country":214,"cosmosGeoPoint":235,"geoPoint":239,"contacts":11},"Climb Bio Investigative Site #702","Santiago","Santiago Metropolitan","8320165",{"type":43,"coordinates":236},[237,238],-70.64827,-33.45694,{"lat":238,"lon":237},{"facility":241,"status":90,"city":242,"state":243,"zip":244,"country":245,"cosmosGeoPoint":246,"geoPoint":250,"contacts":11},"Climb Bio Investigative Site #403","Beijing","Changping District","102218","China",{"type":43,"coordinates":247},[248,249],116.39723,39.9075,{"lat":249,"lon":248},{"facility":252,"status":90,"city":242,"state":253,"zip":254,"country":245,"cosmosGeoPoint":255,"geoPoint":257,"contacts":11},"Climb Bio Investigative Site #401","Cheng District","100034",{"type":43,"coordinates":256},[248,249],{"lat":249,"lon":248},{"facility":259,"status":90,"city":260,"state":261,"zip":262,"country":245,"cosmosGeoPoint":263,"geoPoint":267,"contacts":11},"Climb Bio Investigative Site #408","Shenzhen","Guangdong","518036",{"type":43,"coordinates":264},[265,266],114.0683,22.54554,{"lat":266,"lon":265},{"facility":269,"status":90,"city":270,"state":271,"zip":272,"country":245,"cosmosGeoPoint":273,"geoPoint":277,"contacts":11},"Climb Bio Investigative Site #402","Wuxi","Jiangsu","214023",{"type":43,"coordinates":274},[275,276],120.28857,31.56887,{"lat":276,"lon":275},{"facility":279,"status":90,"city":280,"state":281,"zip":282,"country":245,"cosmosGeoPoint":283,"geoPoint":287,"contacts":11},"Climb Bio Investigative Site #407","Xi'an","Shaanxi","710061",{"type":43,"coordinates":284},[285,286],108.92861,34.25833,{"lat":286,"lon":285},{"facility":289,"status":90,"city":290,"state":291,"zip":292,"country":245,"cosmosGeoPoint":293,"geoPoint":297,"contacts":11},"Climb Bio Investigative Site #405","Jinan","Shandong","250014",{"type":43,"coordinates":294},[295,296],116.99722,36.66833,{"lat":296,"lon":295},{"facility":299,"status":90,"city":300,"state":291,"zip":301,"country":245,"cosmosGeoPoint":302,"geoPoint":306,"contacts":11},"Climb Bio Investigative Site #409","Yantai","264000",{"type":43,"coordinates":303},[304,305],121.44081,37.47649,{"lat":305,"lon":304},{"facility":308,"status":90,"city":309,"state":310,"zip":311,"country":245,"cosmosGeoPoint":312,"geoPoint":316,"contacts":11},"Climb Bio Investigative Site #404","Yibin","Sichuan","644000",{"type":43,"coordinates":313},[314,315],104.63994,28.7593,{"lat":315,"lon":314},{"facility":318,"status":90,"city":242,"state":319,"zip":320,"country":245,"cosmosGeoPoint":321,"geoPoint":323,"contacts":11},"Climb Bio Investigative Site #406","Xicheng District","100044",{"type":43,"coordinates":322},[248,249],{"lat":249,"lon":248},{"facility":325,"status":37,"city":326,"state":11,"zip":327,"country":61,"cosmosGeoPoint":328,"geoPoint":332,"contacts":11},"Climb Bio Investigative Site #903","Tbilisi","0112",{"type":43,"coordinates":329},[330,331],44.83412,41.69143,{"lat":331,"lon":330},{"facility":334,"status":37,"city":326,"state":11,"zip":335,"country":61,"cosmosGeoPoint":336,"geoPoint":338,"contacts":11},"Climb Bio Investigative Site #902","0114",{"type":43,"coordinates":337},[330,331],{"lat":331,"lon":330},{"facility":340,"status":37,"city":326,"state":11,"zip":341,"country":61,"cosmosGeoPoint":342,"geoPoint":344,"contacts":11},"Climb Bio Investigative Site #901","0144",{"type":43,"coordinates":343},[330,331],{"lat":331,"lon":330},{"facility":346,"status":37,"city":347,"state":11,"zip":348,"country":349,"cosmosGeoPoint":350,"geoPoint":354,"contacts":11},"Climb Bio Investigative Site #204","Taichung","404","Taiwan",{"type":43,"coordinates":351},[352,353],120.6839,24.1469,{"lat":353,"lon":352},{"facility":356,"status":90,"city":357,"state":11,"zip":358,"country":349,"cosmosGeoPoint":359,"geoPoint":363,"contacts":11},"Climb Bio Investigative Site# 202","Taipei","100",{"type":43,"coordinates":360},[361,362],121.52639,25.05306,{"lat":362,"lon":361},{"facility":365,"status":37,"city":357,"state":11,"zip":366,"country":349,"cosmosGeoPoint":367,"geoPoint":369,"contacts":11},"Climb Bio Investigative Site# 201","110",{"type":43,"coordinates":368},[361,362],{"lat":362,"lon":361},{"facility":371,"status":37,"city":357,"state":11,"zip":372,"country":349,"cosmosGeoPoint":373,"geoPoint":375,"contacts":11},"Climb Bio Investigative Site #205","112",{"type":43,"coordinates":374},[361,362],{"lat":362,"lon":361},{"facility":377,"status":90,"city":357,"state":11,"zip":378,"country":349,"cosmosGeoPoint":379,"geoPoint":381,"contacts":11},"Climb Bio Investigative Site# 203","235",{"type":43,"coordinates":380},[361,362],{"lat":362,"lon":361},{"facility":383,"status":37,"city":384,"state":11,"zip":385,"country":386,"cosmosGeoPoint":387,"geoPoint":391,"contacts":11},"Climb Bio Investigative Site #803","Ivano-Frankivsk","76008","Ukraine",{"type":43,"coordinates":388},[389,390],24.71248,48.92312,{"lat":390,"lon":389},{"facility":393,"status":37,"city":394,"state":11,"zip":395,"country":386,"cosmosGeoPoint":396,"geoPoint":400,"contacts":11},"Climb Bio Investigative Site# 801","Kyiv","02125",{"type":43,"coordinates":397},[398,399],30.5238,50.45466,{"lat":399,"lon":398},{"facility":402,"status":37,"city":394,"state":11,"zip":403,"country":386,"cosmosGeoPoint":404,"geoPoint":406,"contacts":11},"Climb Bio Investigative Site #805","03151",{"type":43,"coordinates":405},[398,399],{"lat":399,"lon":398},{"facility":408,"status":37,"city":409,"state":11,"zip":410,"country":386,"cosmosGeoPoint":411,"geoPoint":415,"contacts":11},"Climb Bio Investigative Site #804","Rivne","33027",{"type":43,"coordinates":412},[413,414],26.23695,50.62036,{"lat":414,"lon":413},{"facility":417,"status":37,"city":418,"state":11,"zip":419,"country":386,"cosmosGeoPoint":420,"geoPoint":424,"contacts":11},"Climb Bio Investigative Site #802","Ternopil","46002",{"type":43,"coordinates":421},[422,423],25.59067,49.55404,{"lat":423,"lon":422},{"type":426,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100600388",false,"NCT07096843","A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy","A Phase 2, Open-Label Study to Evaluate the Safety and Efficacy of Budoprutug (TNT119) in Subjects With Primary Membranous Nephropathy (PMN)","PrisMN","Inclusion Criteria:\n\n* Confirmed diagnosis of PMN with positive anti-PLA2R antibodies\n* CD19+ B cell count ≥40 cells\u002FμL\n* UPCR ≥2.0 g\u002Fg\n* eGFR ≥35 mL\u002Fmin\u002F1.73 m²\n* Stable RAAS inhibitor therapy\n* Blood pressure \\\u003C150\u002F90 mmHg at baseline\n* Adequate hematologic, hepatic, and renal function\n* Willing to use effective contraception (both sexes)\n* Other inclusion criteria may apply\n\nExclusion Criteria:\n\n* Secondary Membranous Nephropathy\n* Rapidly progressive glomerulonephritis or other glomerulopathies\n* Prior B cell-depleting therapy within 24 weeks\n* Recent use of immunosuppressants\n* Active or high-risk infections\n* History of malignancy\n* Pregnancy or breastfeeding\n* Recent major surgery or hospitalization\n* Other exclusion criteria may apply","ALL","18 Years","75 Years",{"count":438,"type":439},45,"ESTIMATED","INTERVENTIONAL",[442],"PHASE2","To evaluate the safety and tolerability of three dose regimens of budoprutug in subjects with PMN",[445],"Primary Membranous Nephropathy",[447,448,432],"PMN","Anti-CD19","2026-04-28",{"date":451,"type":452},"2026-04-30","ACTUAL",{"date":454,"type":452},"2025-08-25",{"date":456,"type":439},"2027-10",{"name":5,"class":6}]