[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561600":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":28,"locations":35,"responsibleParty":269,"collaborators":28,"id":271,"slug":28,"hasResults":272,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":25,"eligibilityCriteria":276,"healthyVolunteers":272,"sex":277,"minAge":278,"maxAge":279,"enrollmentInfo":280,"targetDuration":28,"studyType":283,"phases":284,"briefSummary":286,"conditions":287,"keywords":289,"overallStatus":38,"whyStopped":28,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":301},{"fullName":5,"class":6},"Huabo Biopharm Co., Ltd.","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group 1","EXPERIMENTAL","HB0017 higer dose plus longer dose regimen",[13],"Biological: HB0017",{"label":15,"type":10,"description":16,"interventionNames":17},"Experimental Group 2","HB0017 higer dose plus shorter dose regimen",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Experimental Group 3","HB0017 low dose plus shortest dose regimen",[13],[23,29,32],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BIOLOGICAL","HB0017","300mg Q12W",[9],null,{"type":24,"name":25,"description":30,"armGroupLabels":31,"otherNames":28},"300mg Q8W",[15],{"type":24,"name":25,"description":33,"armGroupLabels":34,"otherNames":28},"150mg Q4W",[19],[36,54,68,82,96,109,123,139,152,160,174,188,196,210,220,233,246,256],{"facility":37,"status":38,"city":39,"state":40,"zip":28,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"The First Affiliated Hospital of Bengbu Medical College","RECRUITING","Bengbu","Anhui","China",{"type":43,"coordinates":44},"Point",[45,46],117.36083,32.94083,{"lat":46,"lon":45},[49],{"name":50,"role":51,"phone":52,"phoneExt":28,"email":53},"Congjun Jiang","CONTACT","15155281266","fessor5195@163.com",{"facility":55,"status":38,"city":56,"state":57,"zip":28,"country":41,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Southern Medical University Dermatology Hospital","Guangzhou","Guangdong",{"type":43,"coordinates":59},[60,61],113.25,23.11667,{"lat":61,"lon":60},[64],{"name":65,"role":51,"phone":66,"phoneExt":28,"email":67},"Xiaohua Wang","13763359607","wxh_21773@163.com",{"facility":69,"status":38,"city":70,"state":71,"zip":28,"country":41,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Xiangya Hospital of Central South University","Changsha","Hunan",{"type":43,"coordinates":73},[74,75],112.97087,28.19874,{"lat":75,"lon":74},[78],{"name":79,"role":51,"phone":80,"phoneExt":28,"email":81},"Juan Su","15116408921","540020068@.qq.com",{"facility":83,"status":38,"city":84,"state":85,"zip":28,"country":41,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Wuxi Second People's Hospital","Wuxi","Jiangsu",{"type":43,"coordinates":87},[88,89],120.28857,31.56887,{"lat":89,"lon":88},[92],{"name":93,"role":51,"phone":94,"phoneExt":28,"email":95},"Lei Cao","15061830915","caolei_lei@qq.com",{"facility":97,"status":38,"city":98,"state":85,"zip":28,"country":41,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Jiangsu University Affiliated Hospital","Zhenjiang",{"type":43,"coordinates":100},[101,102],119.45508,32.21086,{"lat":102,"lon":101},[105],{"name":106,"role":51,"phone":107,"phoneExt":28,"email":108},"Yumei Li","13914569541","l.yumei@aliyun.com",{"facility":110,"status":38,"city":111,"state":112,"zip":28,"country":41,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Jilin University Second Hospital","Changchun","Jilin",{"type":43,"coordinates":114},[115,116],125.32278,43.88,{"lat":116,"lon":115},[119],{"name":120,"role":51,"phone":121,"phoneExt":28,"email":122},"Fuqiu Li","13039123758","Lifuqiu1234@126.com",{"facility":124,"status":125,"city":126,"state":127,"zip":128,"country":41,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Shandong First Medical University Affiliated Dermatology Hospital","NOT_YET_RECRUITING","Jinan","Shandong","0531",{"type":43,"coordinates":130},[131,132],116.99722,36.66833,{"lat":132,"lon":131},[135],{"name":136,"role":51,"phone":137,"phoneExt":28,"email":138},"Furen Zhang, Doctor","86-13608921718","zhangfuren@hotmail.com",{"facility":140,"status":38,"city":141,"state":127,"zip":128,"country":41,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"Jining First People's Hospital","Jining",{"type":43,"coordinates":143},[144,145],116.58139,35.405,{"lat":145,"lon":144},[148],{"name":149,"role":51,"phone":150,"phoneExt":28,"email":151},"Dongmei Shi","18678769757","shidongmei28@163.com",{"facility":153,"status":38,"city":154,"state":127,"zip":128,"country":41,"cosmosGeoPoint":28,"geoPoint":28,"contacts":155},"Xingtai People's Hospital","Xingtai",[156],{"name":157,"role":51,"phone":158,"phoneExt":28,"email":159},"Fang Cheng","18931912286","chengfang@xtgcp.cn",{"facility":161,"status":38,"city":162,"state":163,"zip":28,"country":41,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Shanxi Medical University Second Hospital","Taiyuan","Shanxi",{"type":43,"coordinates":165},[166,167],112.56028,37.86944,{"lat":167,"lon":166},[170],{"name":171,"role":51,"phone":172,"phoneExt":28,"email":173},"Wenli Feng","13935198008","fwl92@hotmail.com",{"facility":175,"status":38,"city":176,"state":177,"zip":28,"country":41,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"Sichuan Provincial People's Hospital","Chengdu","Sichuan",{"type":43,"coordinates":179},[180,181],104.06667,30.66667,{"lat":181,"lon":180},[184],{"name":185,"role":51,"phone":186,"phoneExt":28,"email":187},"Yangying Liu","13881869265","liuyangying3503@sina.com",{"facility":189,"status":38,"city":190,"state":177,"zip":28,"country":41,"cosmosGeoPoint":28,"geoPoint":28,"contacts":191},"Chongqing Traditional Chinese Medicine Hospital","Chongqing",[192],{"name":193,"role":51,"phone":194,"phoneExt":28,"email":195},"Bin Zhang","13883082218","562868146@qq.com",{"facility":197,"status":38,"city":198,"state":199,"zip":28,"country":41,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Hangzhou First People's Hospital","Hangzhou","Zhejiang",{"type":43,"coordinates":201},[202,203],120.16142,30.29365,{"lat":203,"lon":202},[206],{"name":207,"role":51,"phone":208,"phoneExt":28,"email":209},"Liming Wu","13750837205","18957118053@163.com",{"facility":211,"status":38,"city":198,"state":199,"zip":28,"country":41,"cosmosGeoPoint":212,"geoPoint":214,"contacts":215},"The First Affiliated Hospital of Zhejiang University School of Medicine",{"type":43,"coordinates":213},[202,203],{"lat":203,"lon":202},[216],{"name":217,"role":51,"phone":218,"phoneExt":28,"email":219},"Jianjun Qiao","13735542393","qiaojianjun321@sina.com",{"facility":221,"status":38,"city":222,"state":199,"zip":28,"country":41,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Jiaxing First Hospital","Jiaxing",{"type":43,"coordinates":224},[225,226],120.75,30.7522,{"lat":226,"lon":225},[229],{"name":230,"role":51,"phone":231,"phoneExt":28,"email":232},"Wenhao Yin","13957323606","whyin69@sina.com",{"facility":234,"status":38,"city":235,"state":199,"zip":28,"country":41,"cosmosGeoPoint":236,"geoPoint":240,"contacts":241},"Wenzhou Medical University Affiliated First Hospital","Wenzhou",{"type":43,"coordinates":237},[238,239],120.66682,27.99942,{"lat":239,"lon":238},[242],{"name":243,"role":51,"phone":244,"phoneExt":28,"email":245},"Zhiming Li","15988718867","zhi-mingli@163.com",{"facility":247,"status":38,"city":56,"state":28,"zip":28,"country":41,"cosmosGeoPoint":248,"geoPoint":250,"contacts":251},"Guangdong Provincial People's Hospital",{"type":43,"coordinates":249},[60,61],{"lat":61,"lon":60},[252],{"name":253,"role":51,"phone":254,"phoneExt":28,"email":255},"Zhu Shen","13983174426","zhshencq@163.com",{"facility":257,"status":38,"city":258,"state":28,"zip":28,"country":41,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"Ningbo Second Hospital","Ningbo",{"type":43,"coordinates":260},[261,262],121.54945,29.87819,{"lat":262,"lon":261},[265],{"name":266,"role":51,"phone":267,"phoneExt":28,"email":268},"Jinyan Wang","13586795265","nbwangjinyan@126.com",{"type":270,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100561600",false,"NCT06592274","A Phase 2 Study of HB0017 in Psoriasis Patients","A Multicenter, Randomized, Double-blind Phase 2 Clinical Study Evaluating the Efficacy and Safety of Different Administration Regimens of HB0017 Injection in Patients With Moderate to Severe Plaque Psoriasis","Inclusion Criteria:\n\n* Male or female subjects aged 18-75 years (inclusive)\n* Chronic plaque psoriasis (PSO) for at least 6 months prior to the randomization.\n* Psoriasis Area Severity Index (PASI) \\>=12 and body surface area (BSA) affected by PSO \\>=10% and Static Physician Global Assessment (sPGA) score \\>=3.\n* Subjects who are suitable for systemic treatment or phototherapy for psoriasis as judged by the investigator\n* Subjects who are able to use effective contraception from the screening period to 6 months after the last dose\n\nExclusion Criteria:\n\n* Forms of psoriasis other than chronic plaque-type (e.g., pustular, erythrodermic and\u002For guttate psoriasis) at screening or baseline Drug-induced psoriasis\n* Ongoing use of prohibited treatments\n* Any active infection (other than common cold) within 14 days\n* Serious infection defined as requiring hospitalization or iv anti-infective(s) within 1 month prior to randomization\n* Have previously received any drug that directly targets IL-17 or IL-17 receptor\n* Have concurrent or recent use of any biologic agent within the following washout periods: etanercept \\<28 days; infliximab and adalimumab \\<60 days; golimumab \\< 90 days; anti-IL-12\u002Fanti-IL-23 or anti-IL-23p19 antibody drugs \\<6 months; or other anti-psoriatic therapy not listed herein within its 5 half-lives prior to randomization\n* A history of inflammatory bowel disease or other serious autoimmune disease\n* Previously diagnosed with serious mental illness such as anxiety, depression or suicidal tendency","ALL","18 Years","75 Years",{"count":281,"type":282},200,"ESTIMATED","INTERVENTIONAL",[285],"PHASE2","This study is a randomized, double-blind phase 2 clinical trial aimed at exploring the efficacy, safety, and immunogenicity of HB0017 injection with different dosing regimens in the treatment of moderate to severe plaque psoriasis in subjects",[288],"Psoriasis (PsO)",[25,290,291],"psoriasis","longer dose regimen","2025-09-09",{"date":294,"type":295},"2025-09-15","ACTUAL",{"date":297,"type":295},"2024-09-30",{"date":299,"type":282},"2026-01-30",{"name":5,"class":6},18]