A Study of Adebrelimab in Combination with Chemo with or Without Bevacizumab Neoadjuvant Therapy for Resectable NSCLC

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorThe First Affiliated Hospital of Guangzhou Medical University

About this trial

This is a prospective, multicenter, randomized, uncontrolled Phase II study to assess the efficacy and safety of adebrelimab in combination with chemotherapy with or without bevacizumab for the treatment of resectable Stage II-IIIB (T3N2) NSQ-NSCLC and to explore biomarkers associated with efficacy.

Eligibility criteria

Qualifiers

Resectable NSQ NSCLC

Age 18-65 years

male or female

ECOG 0-1

Disqualifiers

SCLC or SQ NSCLC

previously used anti-PD1, anti-PDL1, anti-CTLA4 antibodies, etc.

patients who have previously used anti-angiogenic drugs;

allergic to any component of the study drug or chemotherapy drugs

Trial design

Treatments tested in this trial

  • Adebellizumab
  • Bevacizumab
  • Platinum-based chemotherapy

Treatment groups

60 Participants
are divided into 2 treatment groups

Locations

1
Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China

Sponsors and collaborators

The First Affiliated Hospital of Guangzhou Medical University

Lead sponsor