[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100344002":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":37,"centralContacts":41,"locations":47,"responsibleParty":63,"collaborators":24,"id":65,"slug":24,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":22,"acronym":24,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":24,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":24,"overallStatus":49,"whyStopped":24,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Rochester","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Baseline PET","EXPERIMENTAL","R-CHOP",[13,14,15,16,17],"Drug: Rituximab Prednisone","Drug: Cyclophosphamide","Drug: Doxorubicin","Drug: Vincristine","Drug: Prednisone",[19,25,28,31,34],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Rituximab Prednisone","A Phase II Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma",[9],null,{"type":20,"name":26,"description":22,"armGroupLabels":27,"otherNames":24},"Cyclophosphamide",[9],{"type":20,"name":29,"description":22,"armGroupLabels":30,"otherNames":24},"Doxorubicin",[9],{"type":20,"name":32,"description":22,"armGroupLabels":33,"otherNames":24},"Vincristine",[9],{"type":20,"name":35,"description":22,"armGroupLabels":36,"otherNames":24},"Prednisone",[9],[38],{"name":39,"affiliation":5,"role":40},"Carla Casulo","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":24,"email":46},"Robin Boerman","CONTACT","585-273-1507","Robin_Boerman@URMC.Rochester.edu",[48],{"facility":5,"status":49,"city":50,"state":51,"zip":52,"country":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Rochester","New York","14642","United States",{"type":55,"coordinates":56},"Point",[57,58],-77.61556,43.15478,{"lat":58,"lon":57},[61],{"name":62,"role":44,"phone":24,"phoneExt":24,"email":24},"Andrew Bui",{"type":40,"investigatorFullName":39,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Associate Professor of Hematology\u002FOncology","100344002",false,"NCT03758989","A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma","Inclusion Criteria:\n\n* Previously untreated limited stage non bulky DLBCL; defined as limited stage by routine staging criteria in lymphoma involving FDG-PET and bone marrow biopsies (the Lugano criteria)\\[21\\]\n* Patients with grade 3B follicular lymphoma and transformed indolent lymphoma are included\n* Ages ≥ 18\n* Measurable disease, assessable by radiographic examination with FDG-PET showing involvement\n* Access to archived or fresh\u002Ffrozen tumor biopsies\n* No uncontrolled medical comorbidities\n* Adequate cardiac function (EF \\> or equal to 50%), no unstable angina\n* Adequate renal function (GFR \\> 60)\n* Adequate liver function (liver function tests should be no greater than 2 x upper limit of normal) including normal bilirubin levels, no greater than 2 x upper limit of normal unless patient has a history of Gilbert's disease\n* Adequate marrow reserves as indicated by complete blood count in the judgment of the treating investigator\n\nExclusion Criteria:\n\n* Pregnancy, positive serum HCG within 28 days of enrollment, or breast-feeding\n* Bulky disease greater than 10 cm in any dimension","ALL","18 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"PHASE2","The overarching goals of this study are to measure levels of circulating tumor DNA (ctDNA) in patients with early stage diffuse large B cell lymphoma (DLBCL), to assess the change in ctDNA during treatment in order to prospectively identify markers of treatment failure, and to use ctDNA as a future tool for response adapted therapy.",[80],"DLBCL","2026-02-04",{"date":83,"type":84},"2026-02-09","ACTUAL",{"date":86,"type":84},"2019-05-08",{"date":88,"type":74},"2027-06-01",{"name":5,"class":6},1]