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Reported Index (ESSPRI) scale and the ESSPRI fatigue scale\n* Of non childbearing potential or of childbearing potential and using highly effective contraceptive measures\n\nExclusion Criteria:\n\n* Diagnosis of any active autoimmune disease other than pSS that could affect the efficacy assessments\n* Uncontrolled hypothyroidism or severe fibromyalgia\n* New medications or change in medications in the last 4 weeks for pSS symptoms\n* Receipt of other prohibited medications\n* Apheresis or blood donation\n* Allergic reaction to RSLV-132 or biologic therapy\n* Clinically significant infection in last 30 days\n* Participation in another clinical study\n* Malignancy in last 5 years\n* Positive test for HIV or hepatitis\n* Major surgery in last 30 days or anticipated surgery during the study\n* Pregnancy or breast feeding\n* Laboratory blood tests outside of specified ranges\n* Other medical conditions or medications that would make the participant unsuitable","FEMALE","18 Years","75 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The main questions it aims to answer are:\n\n* Does RSLV-132 improve the cardinal symptoms of Sjogren's including fatigue, dryness and pain?\n* Does RSLV-132 improve the tiredness\u002Ffatigue caused by Sjogren's?\n* What are the blood levels of RSLV-132 over time?\n* What is the immune (antibody) response in the body to RSLV-132?\n* What is the safety profile of RSLV-132?\n\nResearchers will compare RSLV-132 to a placebo (a look-alike substance that contains no drug) to see if RSLV-132 improves the symptoms of pSS.\n\nParticipants will:\n\nTake RSLV-132 or a placebo 13 times over 22 weeks Visit the clinic once every week for the first 2 weeks, then every 2 weeks until the end of treatment and then for a final time 4 weeks later (Day 211) for check-ups, tests and to answer questionnaires about their symptoms Record their symptoms every day on an electronic device",[324],"Primary Sjögren Syndrome","2025-07-15",{"date":327,"type":328},"2025-07-18","ACTUAL",{"date":330,"type":328},"2024-12-01",{"date":332,"type":318},"2027-03-01",{"name":5,"class":6},24]