A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

ConditionsLung Cancer Lung Cancer Metastatic Brain Metastases Brain Metastases, Adult Small-cell Lung Cancer Small Cell Lung Carcinoma

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18+

SponsorMemorial Sloan Kettering Cancer Center

About this trial

The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

Eligibility criteria

Qualifiers

Histologic diagnosis of small cell lung cancer

Radiographic diagnosis of up to 20 brain metastases on contrast-enhanced MRI

Age 18 and above

Performance status KPS 60-100/ECOG 0-2

Disqualifiers

Unable to undergo contrast-enhanced MRI brain

Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine

Pregnant or lactating women

Prior brain-directed radiotherapy

Trial design

Treatments tested in this trial

Stereotactic Radiosurgery
Cerebrospinal fluid collection

Treatment groups

62 Participants

are divided into 1 treatment group

Locations

Memorial Sloan Kettering at Basking Ridge07920, Basking RidgeNew Jersey, United States

Memorial Sloan Kettering Monmouth07748, MiddletownNew Jersey, United States

Memorial Sloan Kettering Bergen07645, MontvaleNew Jersey, United States

Memorial Sloan Kettering Suffolk - Commack11725, CommackNew York, United States

Sponsors and collaborators

Memorial Sloan Kettering Cancer Center

Lead sponsor

Source ClinicalTrials.gov