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Clinic","Yokohama","223-0059",{"type":64,"coordinates":659},[660,661],139.65,35.43333,{"lat":661,"lon":660},{"facility":664,"status":71,"city":665,"state":40,"zip":666,"country":667,"cosmosGeoPoint":668,"geoPoint":672,"contacts":40},"Allergy Clinic Homeo Medicus","Bialystok","15-687","Poland",{"type":64,"coordinates":669},[670,671],23.16433,53.13333,{"lat":671,"lon":670},{"facility":674,"status":71,"city":675,"state":40,"zip":676,"country":667,"cosmosGeoPoint":677,"geoPoint":681,"contacts":40},"Uniwersyteckie Centrum Kliniczne","Gdansk","80-214",{"type":64,"coordinates":678},[679,680],18.64912,54.35227,{"lat":680,"lon":679},{"facility":683,"status":71,"city":684,"state":40,"zip":685,"country":667,"cosmosGeoPoint":686,"geoPoint":690,"contacts":40},"Nzoz Atopia","Krakow","31-142",{"type":64,"coordinates":687},[688,689],19.93658,50.06143,{"lat":689,"lon":688},{"facility":692,"status":58,"city":693,"state":40,"zip":694,"country":667,"cosmosGeoPoint":695,"geoPoint":699,"contacts":40},"Szpital Specjalistyczny Cdt Medicus","Lubin","59-300",{"type":64,"coordinates":696},[697,698],16.20149,51.40089,{"lat":698,"lon":697},{"facility":701,"status":71,"city":702,"state":40,"zip":703,"country":667,"cosmosGeoPoint":704,"geoPoint":708,"contacts":40},"Ostrowieckie Centrum Medyczne Spka Cywilna Anna Olech-Cudzik Krzysztof Cudzik","Ostrowiec Świętokrzyski","27-400",{"type":64,"coordinates":705},[706,707],21.38525,50.92936,{"lat":707,"lon":706},{"facility":710,"status":58,"city":711,"state":40,"zip":712,"country":667,"cosmosGeoPoint":713,"geoPoint":717,"contacts":40},"Pim Mswia","Warsaw","02-507",{"type":64,"coordinates":714},[715,716],21.01178,52.22977,{"lat":716,"lon":715},{"facility":719,"status":71,"city":720,"state":40,"zip":721,"country":722,"cosmosGeoPoint":723,"geoPoint":727,"contacts":40},"Giromed Institute\u002F Clinica Tres Torrres","Barcelona","08017","Spain",{"type":64,"coordinates":724},[725,726],2.15899,41.38879,{"lat":726,"lon":725},{"facility":729,"status":71,"city":720,"state":40,"zip":730,"country":722,"cosmosGeoPoint":731,"geoPoint":733,"contacts":40},"Hospital Clinic Barcelona Main","08036",{"type":64,"coordinates":732},[725,726],{"lat":726,"lon":725},{"type":735,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100504677",false,"NCT05851443","A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma","A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma","Inclusion Criteria:\n\n* Physician-diagnosed asthma requiring treatment with medium- to high-dose ICS-LABA for at least 12 months prior to screening.\n* Pre-BD FEV1 \\\u003C 80% predicted according to central over read value at Visit 2.\n* Documented historical post-BD reversibility of FEV1 ≥ 12% and ≥ 200 mL in FEV1.\n* At least 2 documented asthma exacerbations (requiring treatment with systemic CS, hospitalization, or emergency department visit) within 12 months prior to screening but not within the past 4 weeks prior to screening\n* ACQ-6 ≥ 1.5 at screening.\n\nExclusion Criteria:\n\n* Maintenance use of asthma controllers other than ICS-LABA.\n* Have undergone bronchial thermoplasty.\n* Current smokers or participants with a smoking history of ≥ 10 pack-years and participants using vaping products, including electronic cigarettes.\n* Women who are pregnant (or who are considering pregnancy) or breastfeeding.\n* Current conditions or history of other diseases, as follows:\n* Clinically important pulmonary disease other than asthma ,Thrombocytopenia, coagulopathy, or platelet dysfunction.\n* Venous and arterial thrombosis, deep vein thrombosis, pulmonary embolism, moderate to severe heart failure (NYHA Class III or IV), cerebrovascular accident, myocardial infarction, coronary stenting, or CABG surgery.\n* Diagnosis of other significant cardiovascular diseases, including but not limited to angina, peripheral arterial disease, or uncontrolled arrhythmias such as atrial fibrillation, supraventricular tachycardia, ventricular tachycardia, and forms of carditis.\n* Recipient of an organ transplant that requires continued immunosuppression.\n* Immunocompromised (eg, lymphoma, acquired immunodeficiency syndrome, Wiskott-Aldrich syndrome).\n* Any malignancies or history of malignancies.\n* Chronic or recurrent infectious disease.\n* Receipt of any biologic drugs used for asthma \\\u003C 12 weeks or 5 half-lives (if known), whichever is longer, prior to screening","ALL","18 Years","65 Years",{"count":746,"type":747},240,"ESTIMATED","INTERVENTIONAL",[750],"PHASE2","The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function",[753],"Moderate to Severe Asthma",[755,756,35,757,42],"Asthma","Moderate to Severe","Povorcitinib","2026-04-10",{"date":760,"type":761},"2026-04-14","ACTUAL",{"date":763,"type":761},"2023-07-11",{"date":765,"type":747},"2027-01-31",{"name":5,"class":6},83]