The main purpose of the study is to evaluate the efficacy of selnoflast compared with placebo in participants with atherosclerosis, at high-risk for major adverse cardiovascular event (MACE), who are currently on standard-of-care (SOC) therapy.
Confirmed evidence of atherosclerosis
Left or right carotid TBR ≥ 1.8 or aorta TBR ≥ 2.0 on centrally-assessed 18F-fluorodeoxyglucose-Positron Emission Tomography (18F-FDG-PET) scan
Stable treatment of atherosclerosis through the use of SOC medications or revascularization
QT interval corrected through use of Fridericia's formula (QTcF) of ≤ 450 milliseconds (ms) in men and ≤ 470 ms in women by a single 12-lead electrocardiogram (ECG) recording
Individuals with Class III and IV heart failure
Uncontrolled cardiac arrhythmia
Uncontrolled hypertension
Suspected or known immunocompromised state
Genentech, Inc.
Lead sponsor