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276897","Charleroi","Hainaut","6280","Belgium",{"type":77,"coordinates":178},[179,180],4.44448,50.41136,{"lat":180,"lon":179},{"facility":183,"status":71,"city":184,"state":185,"zip":186,"country":176,"cosmosGeoPoint":187,"geoPoint":191,"contacts":41},"Groupe Sante CHC - Clinique du MontLegia \u002FID# 276783","Liège","Liege","4000",{"type":77,"coordinates":188},[189,190],5.56749,50.63373,{"lat":190,"lon":189},{"facility":193,"status":71,"city":194,"state":195,"zip":196,"country":176,"cosmosGeoPoint":197,"geoPoint":201,"contacts":41},"Jessa Ziekenhuis - Campus Virga Jesse \u002FID# 276781","Hasselt","Limburg","3500",{"type":77,"coordinates":198},[199,200],5.33781,50.93106,{"lat":200,"lon":199},{"facility":203,"status":71,"city":204,"state":205,"zip":206,"country":176,"cosmosGeoPoint":207,"geoPoint":211,"contacts":41},"AZ Maria Middelares \u002FID# 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District","7747600",{"type":77,"coordinates":303},[304,305],34.64966,31.79213,{"lat":305,"lon":304},{"facility":308,"status":71,"city":309,"state":310,"zip":311,"country":291,"cosmosGeoPoint":312,"geoPoint":316,"contacts":41},"The Chaim Sheba Medical Center \u002FID# 276660","Ramat Gan","Tel Aviv","5265601",{"type":77,"coordinates":313},[314,315],34.81065,32.08227,{"lat":315,"lon":314},{"facility":318,"status":71,"city":319,"state":41,"zip":320,"country":291,"cosmosGeoPoint":321,"geoPoint":325,"contacts":41},"Rambam Health Care Campus- Haifa \u002FID# 276663","Haifa","3109601",{"type":77,"coordinates":322},[323,324],34.99928,32.81303,{"lat":324,"lon":323},{"facility":327,"status":71,"city":328,"state":41,"zip":329,"country":291,"cosmosGeoPoint":330,"geoPoint":334,"contacts":41},"Hadassah Medical Center-Hebrew University \u002FID# 276662","Jerusalem","91120",{"type":77,"coordinates":331},[332,333],35.21633,31.76904,{"lat":333,"lon":332},{"facility":336,"status":71,"city":337,"state":338,"zip":339,"country":340,"cosmosGeoPoint":41,"geoPoint":41,"contacts":41},"National Cancer Center Hospital East \u002FID# 277239","Kashiwa-shi","Chiba","277-8577","Japan",{"facility":342,"status":71,"city":343,"state":344,"zip":345,"country":340,"cosmosGeoPoint":41,"geoPoint":41,"contacts":41},"Shizuoka Cancer Center \u002FID# 277243","Sunto-gun","Shizuoka","411-8777",{"facility":347,"status":71,"city":348,"state":349,"zip":350,"country":340,"cosmosGeoPoint":41,"geoPoint":41,"contacts":41},"Tokyo Metropolitan Komagome Hospital \u002FID# 277335","Bunkyo Ku","Tokyo","113-8677",{"facility":352,"status":71,"city":353,"state":349,"zip":354,"country":340,"cosmosGeoPoint":41,"geoPoint":41,"contacts":41},"National Cancer Center Hospital \u002FID# 277237","Chuo-Ku","104-0045",{"facility":356,"status":71,"city":357,"state":357,"zip":358,"country":340,"cosmosGeoPoint":359,"geoPoint":363,"contacts":41},"Wakayama Medical University Hospital \u002FID# 277260","Wakayama","641-8510",{"type":77,"coordinates":360},[361,362],135.16667,34.23333,{"lat":362,"lon":361},{"facility":365,"status":71,"city":366,"state":367,"zip":368,"country":369,"cosmosGeoPoint":370,"geoPoint":374,"contacts":41},"Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeyla \u002FID# 276907","Poznan","Greater Poland Voivodeship","60-569","Poland",{"type":77,"coordinates":371},[372,373],16.92993,52.40692,{"lat":373,"lon":372},{"facility":376,"status":71,"city":377,"state":378,"zip":379,"country":369,"cosmosGeoPoint":380,"geoPoint":384,"contacts":41},"Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie \u002FID# 276910","Lublin","Lublin Voivodeship","20-090",{"type":77,"coordinates":381},[382,383],22.57009,51.25058,{"lat":383,"lon":382},{"facility":386,"status":71,"city":387,"state":388,"zip":389,"country":369,"cosmosGeoPoint":390,"geoPoint":394,"contacts":41},"Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada \u002FID# 277112","Warsaw","Masovian Voivodeship","02-781",{"type":77,"coordinates":391},[392,393],21.01178,52.22977,{"lat":393,"lon":392},{"facility":396,"status":71,"city":397,"state":398,"zip":399,"country":400,"cosmosGeoPoint":401,"geoPoint":405,"contacts":41},"University Clinical Center Serbia \u002FID# 277007","Belgrade","Beograd","11000","Serbia",{"type":77,"coordinates":402},[403,404],20.46513,44.80401,{"lat":404,"lon":403},{"facility":407,"status":71,"city":397,"state":398,"zip":408,"country":400,"cosmosGeoPoint":409,"geoPoint":411,"contacts":41},"Clinical Hospital Center - Bežanijska Kosa \u002FID# 277013","11080",{"type":77,"coordinates":410},[403,404],{"lat":404,"lon":403},{"facility":413,"status":71,"city":414,"state":415,"zip":416,"country":400,"cosmosGeoPoint":417,"geoPoint":421,"contacts":41},"University Clinical Center Nis \u002FID# 277180","Niš","Nisavski Okrug","18300",{"type":77,"coordinates":418},[419,420],21.90333,43.32472,{"lat":420,"lon":419},{"facility":423,"status":71,"city":424,"state":425,"zip":426,"country":400,"cosmosGeoPoint":427,"geoPoint":431,"contacts":41},"Institute For Pulmonary Diseases Of Vojvodina \u002FID# 277003","Kamenitz","Sremski Okrug","21208",{"type":77,"coordinates":428},[429,430],19.84263,45.22334,{"lat":430,"lon":429},{"facility":433,"status":71,"city":434,"state":435,"zip":436,"country":400,"cosmosGeoPoint":437,"geoPoint":441,"contacts":41},"University Clinical Center Kragujevac \u002FID# 277179","Kragujevac","Sumadijski Okrug","34000",{"type":77,"coordinates":438},[439,440],20.91667,44.01667,{"lat":440,"lon":439},{"facility":443,"status":71,"city":444,"state":445,"zip":446,"country":447,"cosmosGeoPoint":448,"geoPoint":452,"contacts":41},"National Cancer Center \u002FID# 277434","Goyang-si","Gyeonggido","10408","South Korea",{"type":77,"coordinates":449},[450,451],126.835,37.65639,{"lat":451,"lon":450},{"facility":454,"status":71,"city":455,"state":456,"zip":457,"country":447,"cosmosGeoPoint":458,"geoPoint":462,"contacts":41},"Chungbuk National University Hospital \u002FID# 277429","Cheongju-si","North Chungcheong","28644",{"type":77,"coordinates":459},[460,461],127.48972,36.63722,{"lat":461,"lon":460},{"facility":464,"status":71,"city":465,"state":466,"zip":467,"country":447,"cosmosGeoPoint":468,"geoPoint":472,"contacts":41},"Seoul National University Hospital \u002FID# 277271","Seoul","Seoul Teugbyeolsi","03080",{"type":77,"coordinates":469},[470,471],126.9784,37.566,{"lat":471,"lon":470},{"facility":474,"status":71,"city":465,"state":466,"zip":475,"country":447,"cosmosGeoPoint":476,"geoPoint":478,"contacts":41},"Yonsei University Health System Severance Hospital \u002FID# 277597","03722",{"type":77,"coordinates":477},[470,471],{"lat":471,"lon":470},{"facility":480,"status":71,"city":465,"state":466,"zip":481,"country":447,"cosmosGeoPoint":482,"geoPoint":484,"contacts":41},"Asan Medical Center \u002FID# 277603","05505",{"type":77,"coordinates":483},[470,471],{"lat":471,"lon":470},{"facility":486,"status":71,"city":465,"state":466,"zip":487,"country":447,"cosmosGeoPoint":488,"geoPoint":490,"contacts":41},"Samsung Medical Center \u002FID# 277615","06351",{"type":77,"coordinates":489},[470,471],{"lat":471,"lon":470},{"facility":492,"status":71,"city":493,"state":494,"zip":495,"country":496,"cosmosGeoPoint":497,"geoPoint":501,"contacts":41},"Complejo Hospitalario Universitario A Coruña \u002FID# 276922","A Coruña","A Coruna","15006","Spain",{"type":77,"coordinates":498},[499,500],-8.396,43.37135,{"lat":500,"lon":499},{"facility":503,"status":71,"city":504,"state":505,"zip":506,"country":496,"cosmosGeoPoint":507,"geoPoint":511,"contacts":41},"Hospital Regional Universitario de Malaga \u002FID# 276927","Málaga","Andalusia","29010",{"type":77,"coordinates":508},[509,510],-4.42034,36.72016,{"lat":510,"lon":509},{"facility":513,"status":71,"city":514,"state":41,"zip":515,"country":496,"cosmosGeoPoint":516,"geoPoint":520,"contacts":41},"Hospital Clinic de Barcelona \u002FID# 276878","Barcelona","08036",{"type":77,"coordinates":517},[518,519],2.15899,41.38879,{"lat":519,"lon":518},{"facility":522,"status":71,"city":523,"state":41,"zip":524,"country":496,"cosmosGeoPoint":525,"geoPoint":529,"contacts":41},"Hospital Universitario 12 de Octubre \u002FID# 277251","Madrid","28041",{"type":77,"coordinates":526},[527,528],-3.70256,40.4165,{"lat":528,"lon":527},{"facility":531,"status":71,"city":532,"state":41,"zip":533,"country":534,"cosmosGeoPoint":535,"geoPoint":539,"contacts":41},"Kaohsiung Medical University Chung-Ho Memorial Hospital \u002FID# 277267","Kaohsiung City","807","Taiwan",{"type":77,"coordinates":536},[537,538],120.31333,22.61626,{"lat":538,"lon":537},{"facility":541,"status":71,"city":532,"state":41,"zip":542,"country":534,"cosmosGeoPoint":543,"geoPoint":545,"contacts":41},"Kaohsiung Chang Gung Memorial Hospital \u002FID# 277725","833",{"type":77,"coordinates":544},[537,538],{"lat":538,"lon":537},{"facility":547,"status":71,"city":548,"state":41,"zip":549,"country":534,"cosmosGeoPoint":550,"geoPoint":554,"contacts":41},"Chung Shan Medical University Hospital \u002FID# 277660","Taichung","402",{"type":77,"coordinates":551},[552,553],120.6839,24.1469,{"lat":553,"lon":552},{"facility":556,"status":71,"city":557,"state":41,"zip":558,"country":534,"cosmosGeoPoint":559,"geoPoint":563,"contacts":41},"Taipei Veterans General Hospital \u002FID# 277263","Taipei","112",{"type":77,"coordinates":560},[561,562],121.52639,25.05306,{"lat":562,"lon":561},{"facility":565,"status":71,"city":566,"state":41,"zip":567,"country":534,"cosmosGeoPoint":568,"geoPoint":572,"contacts":41},"Linkou Chang Gung Memorial Hospital \u002FID# 277264","Taoyuan City","333",{"type":77,"coordinates":569},[570,571],121.29696,24.99368,{"lat":571,"lon":570},{"facility":574,"status":71,"city":575,"state":41,"zip":576,"country":577,"cosmosGeoPoint":578,"geoPoint":582,"contacts":41},"Gazi University Medical Faculty \u002FID# 276843","Ankara","06560","Turkey (Türkiye)",{"type":77,"coordinates":579},[580,581],32.85427,39.91987,{"lat":581,"lon":580},{"facility":584,"status":71,"city":575,"state":41,"zip":585,"country":577,"cosmosGeoPoint":586,"geoPoint":588,"contacts":41},"Ankara Universitesi Tip Fakultesi Cebeci Hastanesi \u002FID# 277076","06620",{"type":77,"coordinates":587},[580,581],{"lat":581,"lon":580},{"facility":590,"status":71,"city":591,"state":41,"zip":592,"country":577,"cosmosGeoPoint":593,"geoPoint":597,"contacts":41},"Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi \u002FID# 276839","Istanbul","34722",{"type":77,"coordinates":594},[595,596],28.94966,41.01384,{"lat":596,"lon":595},{"type":599,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100604873",false,"NCT07155174","A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer","A Phase 2 Randomized, Open Label, Multicenter Study to Evaluate the Optimal Dose, Safety, and Efficacy of ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Subjects With Previously Untreated Extensive Stage Small Cell Lung Cancer (ES-SCLC)","SEZanne","Inclusion Criteria:\n\n* Diagnosis of histologically or cytologically confirmed extensive stage small cell lung cancer (ES-SCLC) requiring treatment with first line therapy.\n* Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 during the screening period prior to the first dose of study treatment.\n* Have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST v1.1).\n* Suspected brain metastases at screening should have a computed tomography (CT)\u002F magnetic resonance imaging (MRI) of the brain prior to study entry.\n\nExclusion Criteria:\n\n* Have received any kind of treatment for limited stage small cell lung cancer (LS-SCLC).\n* Known active\u002Fsymptomatic central nervous system (CNS) metastases should be excluded.\n* History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, or any evidence of active ILD\u002Fpneumonitis on screening chest computed tomography (CT) scan should be excluded.\n* Have any clinically significant conditions that would adversely affect the participant's participation in the study, and the subject should have a life expectancy of at least 3 months.","ALL","18 Years",{"count":610,"type":611},180,"ESTIMATED","INTERVENTIONAL",[614],"PHASE2","Small cell lung cancer (SCLC) is characterized by aggressive and rapid growth and a tendency to develop early spread to distant sites including mediastinal lymph nodes, liver, bones, adrenal glands, and brain. The purpose of this study is to assess safety, dose, change in disease activity of ABBV-706 given with atezolizumab, compared to standard of care (SOC) treatment (etoposide, carboplatin, atezolizumab, and optional lurbinectedin).\n\nABBV-706 is an investigational drug being developed for the treatment of SCLC. There are multiple treatment arms in this study. Participants will either receive ABBV-706 given with atezolizumab, at 1 of 2 doses, or SOC. Approximately 180 adult participants will be enrolled in the study across sites worldwide.\n\nIn the safety lead-in, participants with SCLC will receive intravenous (IV) ABBV-706 in 1 of 2 doses with IV atezolizumab, or IV SOC. In the expansion portion of the study, participants with SCLC will receive IV ABBV-706 in 1 of 2 doses with atezolizumab, or IV SOC, until the optimal dose of ABBV-706 is determined. The estimated duration of the study is up to 69.5 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, questionnaires, and scans.",[617],"Small Cell Lung Cancer",[617,619,38,47,50,43,56],"SCLC","2026-06-30",{"date":622,"type":623},"2026-07-02","ACTUAL",{"date":625,"type":623},"2025-11-25",{"date":627,"type":611},"2031-09",{"name":5,"class":6},57]