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clinically meaningful improvement from status at admission, at the discretion of Investigator, at the time of randomization\n* Suitable for EUS-guided study drug administration procedure\n* Contrast-enhanced computed tomography (CECT) or magnetic resonance imaging (MRI) of the abdomen\u002Fpancreas available for the evaluation of exclusion criteria\n\nKey Exclusion Criteria:\n\n* Confirmed severe acute pancreatitis as defined by the Revised Atlanta Classification of Acute Pancreatitis (ie, Persistent \\[\\> 48 hours\\] organ failure, per Modified Marshall Score), prior to randomization\n* Anticipated discharge from hospital within 48 hours of randomization\n* More than 30% pancreatic necrosis on screening CECT or MRI\n* History of previous pancreatic necrosis, including necrosectomy\n* History of calcific chronic pancreatitis\n* Evidence of cholangitis","ALL","18 Years","85 Years",{"count":253,"type":254},36,"ESTIMATED","INTERVENTIONAL",[257],"PHASE2","The goal of this clinical trial is to test the safety and effectiveness of a single dose of RABI-767 given by endoscopic ultrasound (EUS) guided peripancreatic injection in participants with predicted severe acute pancreatitis.\n\nThe main question the study aims to answer is:\n\n• Is a single-dose of RABI-767 given by EUS-guided peripancreatic injection safe in patients with predicted severe acute pancreatitis.\n\nThe study also aims to answer:\n\n• Is a single-dose of RABI-767 given by EUS-guided peripancreatic injection effective in treating patients with predicted severe acute pancreatitis.\n\nStudy participants will be randomly assigned (like the flip of a coin) to receive a single dose of RABI-767 plus supportive care or supportive care only.\n\nThe study sponsor will compare safety and efficacy data collected from participants who receive RABI-767 to participants who receive supportive care only to test if RABI-767 is safe and effective.",[260],"Acute 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