[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622521":3},{"organization":4,"outcomesModule":7,"designInfo":32,"detailedDescription":40,"studyPopulation":37,"armGroups":41,"interventions":53,"overallOfficials":64,"centralContacts":69,"locations":79,"responsibleParty":319,"collaborators":321,"id":324,"slug":37,"hasResults":325,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":331,"sex":332,"minAge":333,"maxAge":37,"enrollmentInfo":334,"targetDuration":37,"studyType":337,"phases":338,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":349,"whyStopped":37,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":359},{"fullName":5,"class":6},"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":28},[9],{"measure":10,"description":11,"timeFrame":12},"Desirability of Outcome Ranking (DOOR)","Desirability of Outcome Ranking is an ordinal scale that classifies each patient's overall clinical outcome from 1 to 5, integrating survival, clinical response, and serious adverse events. DOOR 1 represents the most favorable outcome (alive with clinical cure or improvement and no serious adverse events); DOOR 2, clinical cure or improvement with serious adverse events; DOOR 3, alive with clinical failure and no serious adverse events; DOOR 4, clinical failure with serious adverse events; and DOOR 5, death, representing the least desirable outcome. Lower numerical values indicate more favorable overall clinical outcomes.","At day 90 from day 0.",[14,18,21,25],{"measure":15,"description":16,"timeFrame":17},"Mortality","Dead of any cause","At day 14 and day 28 from day of assignment of study drug (day 0)",{"measure":19,"description":20,"timeFrame":12},"Length of stay of inpatient hospitalisation","Length of hospital stay in days from patient enrollment into the study to the time of hospital discharge or death",{"measure":22,"description":23,"timeFrame":24},"Microbiological treatment failure","Defined as a positive S. aureus culture from a sterile site (deep tissue or abscess).","At day 14 and day 90 from day of assignment of study drug (day 0)",{"measure":26,"description":27,"timeFrame":24},"New foci of infection","Diagnosis of new infection foci, based on clinical, radiological, microbiological, or pathological findings.",[29],{"measure":30,"description":31,"timeFrame":12},"Major bleeding","Defined as any bleeding that is fatal, occurs in a critical organ or area, causes a hemoglobin drop of ≥2 g\u002FdL, or requires transfusion of ≥2 units of blood.",{"allocation":33,"interventionModel":34,"interventionModelDescription":35,"primaryPurpose":36,"observationalModel":37,"timePerspective":37,"maskingInfo":38},"RANDOMIZED","PARALLEL","Parallel Assignment Randomized 1:1 to receive either oral clopidogrel for 5 days-administered as a 300 mg loading dose on Day 1 followed by 75 mg once daily on subsequent days-or no antiplatelet therapy (antibiotic treatment according to SNAP assignment).","TREATMENT",null,{"masking":39,"maskingDescription":37,"whoMasked":37},"NONE","The CLOPI-SNAP study evaluates whether the administration of clopidogrel as adjunctive therapy improves clinical outcomes while maintaining an acceptable safety profile in hospitalized patients with Staphylococcus aureus bacteremia (SAB).\n\nTo be eligible for the SNAP platform (NCT 05137119), patients must meet at least two criteria: isolation of the Staphylococcus aureus complex from ≥1 blood culture and admission to a participating hospital at the time of eligibility assessment. SNAP is designed to concurrently evaluate multiple therapeutic strategies. Patients are randomly assigned to different concurrent treatment options that are currently considered acceptable in routine clinical practice; thus, standard-of-care therapy consists of approved antibiotics for the treatment of Staphylococcus aureus infection.\n\nSpecifically, patients participating in CLOPI-SNAP-adult patients with SAB enrolled in the SNAP platform-are randomized in a 1:1 ratio to receive either oral clopidogrel for 5 days, administered as a 300-mg loading dose on Day 1 followed by 75 mg once daily on subsequent days, or no antiplatelet therapy. The primary endpoint is the Desirability of Outcome Ranking (DOOR) assessed at Day 90, a hierarchical composite outcome integrating survival, clinical failure, infectious complications, and the occurrence of serious adverse events. The limited 5-day duration of clopidogrel administration is intended to focus its potential therapeutic benefit on the early phase of infection, characterized by high bacterial burden and systemic inflammation, while minimizing the risk of bleeding associated with prolonged antiplatelet exposure.",[42,48],{"label":43,"type":44,"description":45,"interventionNames":46},"Oral clopidogrel","EXPERIMENTAL","Oral clopidogrel 75 mg pills; 300 mg from domain reveal (day 1 of treatment), followed by 75 mg daily until day 5 of treatment inclusive (4 additional calendar days) added to different concurrent antibiotic options currently approved for SAB",[47],"Drug: Clopidogrel",{"label":49,"type":6,"description":50,"interventionNames":51},"No antiplatelet treatment","Patients receive different concurrent antibiotic options currently approved for SAB",[52],"Drug: No antiplatelet treatment",[54,61],{"type":55,"name":56,"description":57,"armGroupLabels":58,"otherNames":59},"DRUG","Clopidogrel","Oral clopidogrel 75 mg pills; 300 mg from domain reveal (day 1 of treatment), followed by 75 mg daily until day 5 of treatment inclusive (4 additional calendar days)",[43],[60],"antiplatelet arm",{"type":55,"name":49,"description":62,"armGroupLabels":63,"otherNames":37},"Different concurrent antibiotic options currently approved for SAB",[49],[65],{"name":66,"affiliation":67,"role":68},"Jesús Rodriguez Baños, PhD","Hospital Universitario Virgen Macarena","STUDY_CHAIR",[70,75],{"name":71,"role":72,"phone":73,"phoneExt":37,"email":74},"Clara Rosso-Fernández, PhD","CONTACT","+34955012144","claram.rosso.sspa@juntadeandalucia.es",{"name":76,"role":72,"phone":77,"phoneExt":37,"email":78},"Silvia Jiménez-Jorge, PhD","+34955013114","silviajimenezjorge@gmail.com",[80,96,109,119,130,140,149,160,173,186,199,211,221,230,242,259,269,279,293,306],{"facility":81,"status":37,"city":82,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":85,"geoPoint":90,"contacts":91},"Hospital General Universitario de Alicante","Alicante","Spain","ES",{"type":86,"coordinates":87},"Point",[88,89],-0.48149,38.34517,{"lat":89,"lon":88},[92],{"name":93,"role":72,"phone":94,"phoneExt":37,"email":95},"Esperanza Merino de Lucas, D","+34966389146","merinoluc@gmail.com",{"facility":97,"status":37,"city":98,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"H.U. Clinic","Barcelona",{"type":86,"coordinates":100},[101,102],2.15899,41.38879,{"lat":102,"lon":101},[105],{"name":106,"role":72,"phone":107,"phoneExt":37,"email":108},"Alex Soriano Viladomiu, D","+34 932275708","asoriano@clinic.cat",{"facility":110,"status":37,"city":98,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":111,"geoPoint":113,"contacts":114},"H.U. Mutua Terrassa",{"type":86,"coordinates":112},[101,102],{"lat":102,"lon":101},[115],{"name":116,"role":72,"phone":117,"phoneExt":37,"email":118},"Lucía Boix Palop, D","+34 936784872","lboix@mutuaterrassa.cat ; luciaboix@hotmail.com",{"facility":120,"status":37,"city":98,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":121,"geoPoint":123,"contacts":124},"Hospital del Mar",{"type":86,"coordinates":122},[101,102],{"lat":102,"lon":101},[125],{"name":126,"role":72,"phone":127,"phoneExt":128,"email":129},"Maria M Montero, D","+34 932483251","3251","mmontero@psmar.cat",{"facility":131,"status":37,"city":98,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":132,"geoPoint":134,"contacts":135},"Hospital Universitario Bellvitge",{"type":86,"coordinates":133},[101,102],{"lat":102,"lon":101},[136],{"name":137,"role":72,"phone":138,"phoneExt":37,"email":139},"Francesc Escrihuela-Vidal, D","+34932606948","fescrihuela@bellvitgehospital.cat",{"facility":141,"status":37,"city":98,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":142,"geoPoint":144,"contacts":145},"Hospital Universitario de la Santa Creu i Sant Pau",{"type":86,"coordinates":143},[101,102],{"lat":102,"lon":101},[146],{"name":147,"role":72,"phone":37,"phoneExt":37,"email":148},"Sara Grillo, D","sarris.grillo@gmail.com",{"facility":150,"status":37,"city":98,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":151,"geoPoint":153,"contacts":154},"Hospital Universitario Vall d'Hebron",{"type":86,"coordinates":152},[101,102],{"lat":102,"lon":101},[155],{"name":156,"role":72,"phone":157,"phoneExt":158,"email":159},"Nuria Fernández Hidalgo, D","+34 932746000","6090","nufernan@gmail.com",{"facility":161,"status":37,"city":162,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"H.U. Reina Sofía","Córdoba",{"type":86,"coordinates":164},[165,166],-4.77275,37.89155,{"lat":166,"lon":165},[169],{"name":170,"role":72,"phone":171,"phoneExt":37,"email":172},"Isabel M Machuca Sánchez, D","+34 957 011 636","isabelm.machuca.sspa@juntadeandalucia.es",{"facility":174,"status":37,"city":175,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Hospital Universitario San Cecilio","Granada",{"type":86,"coordinates":177},[178,179],-3.60667,37.18817,{"lat":179,"lon":178},[182],{"name":183,"role":72,"phone":184,"phoneExt":37,"email":185},"Francisco Anguita Santos, D","+34 958992536","miparedro@gmail.com",{"facility":187,"status":37,"city":188,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"H.U. Jerez de la Frontera","Jerez de la Frontera",{"type":86,"coordinates":190},[191,192],-6.13606,36.68645,{"lat":192,"lon":191},[195],{"name":196,"role":72,"phone":197,"phoneExt":37,"email":198},"Rubén Lobato Cano, D","+34 665 816 722","ruben.lobato27@gmail.com",{"facility":200,"status":37,"city":201,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Hospital Universitario La paz","Madrid",{"type":86,"coordinates":203},[204,205],-3.70256,40.4165,{"lat":205,"lon":204},[208],{"name":209,"role":72,"phone":37,"phoneExt":37,"email":210},"Beatriz Díaz Pollán, D","bdiazp@salud.madrid.org",{"facility":212,"status":37,"city":201,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":213,"geoPoint":215,"contacts":216},"Hospital Universitario La Princesa",{"type":86,"coordinates":214},[204,205],{"lat":205,"lon":204},[217],{"name":218,"role":72,"phone":219,"phoneExt":37,"email":220},"Carmen Sáez Béjar, D","+34 619515031","carmenmaria.saez@salud.madrid.org",{"facility":222,"status":37,"city":201,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":223,"geoPoint":225,"contacts":226},"Hospital Universitario Ramon y Cajal",{"type":86,"coordinates":224},[204,205],{"lat":205,"lon":204},[227],{"name":228,"role":72,"phone":37,"phoneExt":37,"email":229},"María D Corbacho, D","mariadolores.corbacho@salud.madrid.org",{"facility":231,"status":37,"city":232,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Hospital Universitario Son Espases","Palma de Mallorca",{"type":86,"coordinates":234},[235,236],2.65024,39.56939,{"lat":236,"lon":235},[239],{"name":240,"role":72,"phone":37,"phoneExt":37,"email":241},"Luisa Martin Pena, D","marial.martin@ssib.es",{"facility":243,"status":37,"city":244,"state":37,"zip":245,"country":83,"countryCode":84,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Hospital Virgen Macarena","Seville","41008",{"type":86,"coordinates":247},[248,249],-5.97317,37.38283,{"lat":249,"lon":248},[252,256],{"name":253,"role":72,"phone":254,"phoneExt":37,"email":255},"Esther Recacha Villamor, D","+34635927009","erecachavillamor@gmail.com",{"name":257,"role":72,"phone":37,"phoneExt":37,"email":258},"Alicia Rodríguez Fernández, D","alicia.rodriguez.fernandez.sspa@juntadeandalucia.es",{"facility":260,"status":37,"city":244,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":261,"geoPoint":263,"contacts":264},"H.U. Virgen del Rocío",{"type":86,"coordinates":262},[248,249],{"lat":249,"lon":248},[265],{"name":266,"role":72,"phone":267,"phoneExt":37,"email":268},"José Molina Gil-Bermejo, D","+34 671590280","josemolinagb@gmail.com",{"facility":270,"status":37,"city":244,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":271,"geoPoint":273,"contacts":274},"Hospital Universitario Virgen de Valme",{"type":86,"coordinates":272},[248,249],{"lat":249,"lon":248},[275],{"name":276,"role":72,"phone":277,"phoneExt":37,"email":278},"Nicolás Merchante Gutiérrez, D","+34 95501734","nicolasmerchante@gmail.com",{"facility":280,"status":37,"city":281,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"Hospital Universitario Marqués de Valdecilla","Valdecilla",{"type":86,"coordinates":283},[284,285],-3.73158,43.38347,{"lat":285,"lon":284},[288],{"name":289,"role":72,"phone":290,"phoneExt":291,"email":292},"Francisco Arnaiz de las Revillas Almajano, D","+34 942202520","73263","francisco.arnaizlasrevillas@scsalud.es",{"facility":294,"status":37,"city":295,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"Hospital Universitario Álvaro Cunqueiro","Vigo",{"type":86,"coordinates":297},[298,299],-8.72264,42.23282,{"lat":299,"lon":298},[302],{"name":303,"role":72,"phone":37,"phoneExt":304,"email":305},"Nuria Val Domíguez, D","+34 986217540","nuria.val.dominguez@gmail.com",{"facility":307,"status":37,"city":308,"state":37,"zip":37,"country":83,"countryCode":84,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"Hospital Universitario Lozano Blesa","Zaragoza",{"type":86,"coordinates":310},[311,312],-0.87734,41.65606,{"lat":312,"lon":311},[315],{"name":316,"role":72,"phone":317,"phoneExt":37,"email":318},"Jose Ramón Paño Pardo, D","+34 630585111","joserrapa@gmail.com",{"type":320,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR",[322],{"name":323,"class":6},"University of Melbourne","100622521",false,"NCT07384702","Adjuvant Clopidogrel in Staphylococcus Aureus Bacteremia","Phase 2 Platform Randomized, Multicentre and Open Trial on the Efficacy and Safety of Clopidogrel as Adjuvant Drug in Staphylococcus Aureus Bacteraemia (CLOPI-SNAP)","CLOPI-SNAP","Inclusion Criteria:\n\nTo be eligible, patients must meet the same criteria as those of the general SNAP platform, as well as the domain-specific criteria:\n\n* Microbiological isolation: Presence of Staphylococcus aureus complex in at least one blood culture.\n* Hospitalization status: The patient must be admitted to a participating hospital at the time of eligibility assessment.\n* Time window: Eligibility assessment must be completed within 72 hours after collection of the initial blood culture.\n\nExclusion Criteria:\n\nGeneral Medical and Safety Factors:\n\n* Allergies: Known hypersensitivity to thienopyridines (clopidogrel, prasugrel, ticlopidine).\n* Clinical status: Inability to tolerate or take oral medications, and severe hepatic impairment (Child-Pugh Class C).\n* Pregnancy: Pregnant or breastfeeding women.\n\nHigh Risk of Bleeding or Hematologic Disorders:\n\n* Active or recent bleeding: Significant bleeding or invasive procedures within the previous 7 days.\n* Planned surgeries: Requirement for major surgical intervention within 10 days following study enrollment.\n* Coagulation parameters: Platelet count \\\u003C50,000\u002Fmm³ or known coagulation disorders.\n* Concomitant medications: Patients already receiving regular aspirin therapy, other P2Y12 inhibitors, or therapeutic-dose anticoagulants (prophylactic-dose heparin is permitted).\n\nSpecific Diagnoses and Clinical Criteria:\n\n* Endocarditis: Confirmed diagnosis or clinical suspicion of bacterial endocarditis. Sources indicate that exclusion of endocarditis is justified because the potential benefit of clopidogrel is expected during early phases of high bacterial burden, whereas bleeding risk increases with prolonged treatment or established deep-seated infections.\n* Medical judgment: If the treating clinical team determines that participation in this domain is not in the patient's best interest.",true,"ALL","18 Years",{"count":335,"type":336},230,"ESTIMATED","INTERVENTIONAL",[339],"PHASE2","The CLOPI-SNAP study is a randomized, multicenter, open-label clinical trial embedded within the SNAP (NCT 05137119) research platform. It constitutes a sub-study added to the core protocol for patients suffering Staphylococcus aureus bacteremia (SAB).",[342],"Bacteremia Due to Staphylococcus Aureus",[344,345,346,347,56,348],"bacteriemia","Staphylococcus aureus","adjunctive treatment","Platform trial","Desirability of Outcome Ranking","NOT_YET_RECRUITING","2026-02-03",{"date":352,"type":353},"2026-02-05","ACTUAL",{"date":355,"type":336},"2026-06",{"date":357,"type":336},"2030-06",{"name":5,"class":6},20]