[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542185":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":55,"collaborators":20,"id":57,"slug":20,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":20,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"VT-NMD arm","EXPERIMENTAL","all patients will be trialed on volume targeted non invasive ventilation",[13],"Device: Volume-targeted non-invasive ventilation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Volume-targeted non-invasive ventilation","A target tidal volume is set on the ventilation device, and the device will then automatically adjust delivered pressures to reach this target tidal volume.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Patrick Murphy","CONTACT","02071888070","Patrick.murphy@gstt.nhs.uk",[28,44],{"facility":29,"status":30,"city":31,"state":31,"zip":32,"country":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Guy's & St Thomas' NHS Foundation Trust","RECRUITING","London","SE1 9RT","United Kingdom",{"type":35,"coordinates":36},"Point",[37,38],-0.12574,51.50853,{"lat":38,"lon":37},[41],{"name":42,"role":24,"phone":25,"phoneExt":20,"email":43},"Gillian Radcliffe","Gillian.Radcliffe@gstt.nhs.uk",{"facility":45,"status":30,"city":31,"state":20,"zip":46,"country":33,"cosmosGeoPoint":47,"geoPoint":49,"contacts":50},"Guy's and St. Thomas NHS Foundation Trust","SE1 7EH",{"type":35,"coordinates":48},[37,38],{"lat":38,"lon":37},[51,54],{"name":52,"role":24,"phone":20,"phoneExt":20,"email":53},"Neeraj Shah","neeraj.shah@gstt.nhs.uk",{"name":42,"role":24,"phone":20,"phoneExt":20,"email":43},{"type":56,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100542185",false,"NCT06339580","Assessment of Volume-targeted Ventilation in Patients With Neuromuscular Disease","A Proof-on-concept Study to Investigate the Potential Use of Volume-targeted Ventilation in Patients With Slowly Progressive Neuromuscular Disease","VT-NMD","Inclusion Criteria:\n\n* Slowly progressive neuromuscular disease\n* Established on fixed bi-level ventilation\n* Documented clinical respiratory stability by supervising clinician (no hospitalizations, respiratory infections or change to ventilator settings in preceding 6 weeks)\n\nExclusion Criteria:\n\n* Rapidly progressive neuromuscular disease\n* Decompensated respiratory failure (pH \\\u003C 7.35)\n* Pregnancy\n* Aged \\\u003C18, \\>80\n* Poor adherence to NIV (\\\u003C4hrs per night)\n* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol","ALL","18 Years","80 Years",{"count":68,"type":69},30,"ESTIMATED","INTERVENTIONAL",[72],"PHASE2","Assessment of safety and efficacy of volume-targeted ventilation in patients with neuromuscular disease.",[75],"Neuromuscular Diseases","2026-06-04",{"date":78,"type":79},"2026-06-08","ACTUAL",{"date":81,"type":79},"2024-04-09",{"date":83,"type":69},"2026-09-30",{"name":5,"class":6},2]